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[namdete]

Hi, I need help pls, now im taking topical dutasteride 0,5% 1 time a week and RU 5% every days, but I tink i need more for regrowth.
I want take a topical estriol, But have a dude with the dose, 1% or 2% estriol every night? maybe need 2ml to cover all bald area.

2% would be supportable, considering shock therapy and then reducing the dose of estriol to 10mg every day.
trichosol would be a good vehicle for a estriol?


I will add dr.pen 1.5mm every week and topical minoxidil 5% 0,5ml everey night, If you consider that I can add something that may be useful to me and is not very harmful, go ahead.

tnks you all, and sorry English is not my main language.

 

[Jakejr]

I use topical Duasteride probably twice a day... I think it really helps. Estriol they have the cream you can rub into scalp. It definitely doesn’t go as systemic as taking pills, so wouldn’t worry.
I’ve made some progress, but along with those 2, I’m going to use RU & topical spironolactone too.. see what that does

 

[John Difool]

Topical spironolactone is not working. It needs to metabolise thru the digestive system to do anything.

 

[John Difool]

I'll take topical estriol like you.

Do you buy your estriol at Whuan hengheda?

People got banned from exposing their sources. You should PM for pointers.

EDIT: delete your post then I'll delete mine.

 

[Ganked By DHT]

What about things that can stimulate aromatase or estrogen synthesis synegistically with estriol? Assuming yes, Forskolin is a good candidate? Can buy it as supplement.

Studies in animals have shown various effects of forskolin, including induction of melatonin production in the pineal glands, increased melanin in hair follicles leading to an increase in pigmentation, increased hair growth, and a protective effect against ultraviolet B light (UBV)-induced apoptosis

Forskolin,which is an adenylate cyclase agonist that upregulates aromatase expression by increasing intracellular cAMP levels (Gonzalez-Robayna et al., 1999), was used as a positive control. As showninFig. 1, forskolin significantly increased the production of 17b-estradiol in the presence of testosterone.

Icariin promotes estrogen biosynthesis in KGN cells by enhan-cing aromatase mRNA and protein expressions, as forskolin does. Forskolin is known to activate adenylate cyclase to increase intracellular cAMP production, resulting in the activation of PKA/CREB for aromatase transcription

Forskolin, an adenylate cyclase activator, promotes hair epithelial cell growth and boosts the growth-promoting effect of procyanidin B-2

Steroidogenesis
Four steroids that were not detected in the unstimulated H295R cells, appeared at detectable levels after forskolin stimulation. These were corticosterone, aldosterone, estradiol and estriol

 

[Jakejr]

I just got 4 bottles of Duasteride for $19 apiece yesterday. IMO Duasteride is a must. Can be applied topically.
I have most of the other chemicals mentioned in thread. I also started magnesium oil & supplements to break up calcification. Perhaps another piece of puzzle..

 

[321nickname123]

I just got 4 bottles of Duasteride for $19 apiece yesterday. IMO Duasteride is a must. Can be applied topically.
I have most of the other chemicals mentioned in thread. I also started magnesium oil & supplements to break up calcification. Perhaps another piece of puzzle..

Could you PM me where you ordered the topical dutasteride?

 

[namdete]

Now i adding bi-estro, but while the estriol reaches me, I will use it at 1% with DMSO that sould be strong to doing any.
I want add more chemicals mentioned in thread.

 

[Jakejr]

It’s apparent that chemicals have an effect. I’m always experimenting. I read some good things on melatonin. So I bought topical of melatonin & a cream of melatonin & magnesium & safflower & aloe vera & argan & lavender. See if it does anything for me.

 

[nick123]

Topical please. I've used from 40mg up to 100mg daily

What are your experiences with estriol? Particularly efficacy and safety.

 

[Jakejr]

It’s weak, so no gyno.
It hits the right receptors in the literature for hair growth. Like all these chemicals, no miracle but makes sense scientifically.
So part of long regimen

 

[John Difool]

What are your experiences with estriol? Particularly efficacy and safety.

It seems to work better than Estradiol and it's extremely safe as an exogenous natural hormone. You need a higher dosage though like 80x more.

 

[John Difool]

It’s apparent that chemicals have an effect. I’m always experimenting. I read some good things on melatonin. So I bought topical of melatonin & a cream of melatonin & magnesium & safflower & aloe vera & argan & lavender. See if it does anything for me.

OTC creams have a very limited effect because they are extremely weak so of course they are safe. And they are pricey! The only OTC creams I use are the protective ones for UV and skin hydration.

 

[Yar]

Counting single hairs is certainly nice ,but I like more effective things

 

[John Difool]

Counting single hairs is certainly nice ,but I like more effective things

What do you suggest?

 

[namdete]

It seems to work better than Estradiol and it's extremely safe as an exogenous natural hormone. You need a higher dosage though like 80x more.

How many mg would be ideal? 10mg at day?

 

[John Difool]

Between 7mg up.till.70mg per day based on the patent. I am using the median (~45mg)

The concentration of the active ingredient in the solution or suspension should be at least 0.02 percent, is preferably at least 0.05 percent, and has a maximum useful upper limit of approximately 0.2 percent. Higher percentages up to about 1 percent may be used if desired but are not economically attractive. Striking results have been obtained at about 0.1 percent or slightly above, but treatment effects can sometimes be increased by increasing the concentration of the active ingredient in the compositions of the invention.

Use of such a composition has been found entirely satisfactory. In many cases, application of approximately 50 ml. of the composition per week has been the prescribed regimen, the treatment period extending from a minimum of twelve to fifteen weeks to four years or even more. In some cases about 20 ml. of the composition is administered for at least about 12 weeks or at least about 6 months.

Estriol 0.1 gram. Benzalkonium chloride (antibacterial surface-active agent) 0.05 gram.
Ethyl alcohol 39.0 grams.
Corrigentia odor As desired.
Distilled water To make 100ml.
of solution.

US3729560A - Treatment of hair and scalp with compositions containing estriol - Google Patents

IMPROVEMENT OR ALLEVIATION OF CERTAIN UNDESIRABLE CONDITIONS OF THE SCALP, INCUDING CERTAIN TYPES OF NON-IRREVERSIBLE HAIRFALL USING ESTRIOL, AND COMPOSITIONS THEREOF PARTICULARLY USEFUL IN SUCH TREATMENT.

patents.google.com

 

[ElToso]

Why would cetirizine upregulate PGF2a? Am I missing something?

Effect of levocetirizine hydrochloride on the growth of human dermal papilla cells: a preliminary study - Wen - Annals of Palliative Medicine

 

[Throwaway99]

@pegasus2

Might be a stupid question given the synergistic nature of your routine, but if you had to pick only 3 compounds outside of dutasteride, micro needling and oral minoxidil to use, what would they be?

 

[mj9]

It doesn't matter how long you've been bald you can regrow hair. It just takes patience. I got on dutasteride around Thanksgiving. I only got really serious about my treatment around 5/2020 when I started adding more experimental treatments.



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9-12-2020

Here's a detailed breakdown of what I do for everyone asking about doses and scheduling. I make rotating batches of 40ml which lasts for 10 days. I apply 2ml morning and evening. Each batch consists of the following:

WAY-316606 100mg WAY is always added first and warmed to 50°C in order to fully dissolve
Dutasteride 20mg
RU58841 1000mg
Estriol 400mg
CHIR99021 10mg
Dinoprost 20mg
Bisindolylmaleimide I CAS 133052-90-1 20mg This is only used in the first batch when it is time to microneedle. I microneedle 24 hours after my first application of this batch.
SW033291 20mg
PGE2 20mg PGE2 is always added last to minimize degradation

It's very important to keep the solution in a tightly sealed container and protected from light. It's ok to store it at room temp. You can store it in the refrigerator too, but it may precipitate some. If it does you'll have to shake it until it dissolves.

The vehicle:

DMSO 4ml : 200 or 195 Ethanol 8ml : Benzyl Alcohol 2ml: PG 24ml : Oleic Acid 2ml : Tween80 just a few drops to a quarter ml.

I make one batch like this and microneedle 24 hours after I begin using this batch. IOW I microneedle immediately before or after applying my third batch with BIM-I. Then I make one batch without BIM I before repeating. If I'm being lazy I'll put off microneedling for another ten days and make two batches without BIM-I. Note: BIM-I mildly stains the scalp, but it washes off easily.

Per the latest Cotsarelis patent I apply 2ml of SAG once a day on days 5-8 after wounding, using 1.5mg/ml. I've also tried adding SAG to my entire first batch. This seemed to work quite well, and it's easier to just add 20mg to the first batch rather than making a second solution for SAG. It's also easier on the scalp. The downside is this is riskier and obviously more costly.

To make 4 days worth of SAG I use:
195 ethanol 2ml : PG 5.5ml : Oleic Acid .5ml : SAG 12mg.

That's it for the topicals, now the oral part of the regimen.

Eplerenone 50mg twice a day. I might increase this to 100mg twice a day, but always start lower
Oral Minoxidil 5mg twice a day
Dutasteride .5mg once a day
Rapamycin 7mg once a week

This is a visual of everything I do except for supplements and peptides.
View attachment 147904

Optimal microneedling time will vary depending on the device used. I use a Derminator2 with 12-needle cartridges on the fastest setting, which is 24hz. I never reuse cartridges.


Notes:
At the listed dosages the total cost for everything here is under $300/mo. when bought in bulk. I wasted a lot of money experimenting with different doses and compounds so you don't have to. Concentrations listed here should be sufficient, and you could probably even cut it down to 1ml twice a day to cut the cost in half.

You could also add 120mg of ASC-J9 to each batch for a concentration of .3%. This will degrade the AR in your scalp. The problem with this is ASC is very messy. Also it downregulates NF-kB, so it's not the ideal SARD. A better option would be UT-155, but the price I was quoted would be around 20 grand for a month's supply. Maybe a big group buy could bring it down to a reasonable price.

At some point I will replace CHIR99021 with KY19382 at .05% concentration.

I'm probably going to add TM30089 at .1% because SW increases PGD2 in addition to PGE2 and PGF2a.

This is not a regimen for people who have cancer or other health problems like heart disease, liver or kidney problems, and it's not something to be on indefinitely. This is an aggressive way to get your hair back without feminization, and then maintain with dutasteride.

Some people may want to forego oral dutasteride and only use topical dutasteride, or vice versa. I can say that with this vehicle the absorption rate is high, and topical dutasteride having a long half-life will go systemic. Also, some people may get some sides with estriol at this dosage. In that case they can lower the dosage to 10mg/day where almost no one should get sides. If you're extra sensitive to AA therapy then you could eliminate dutasteride altogether and still likely get excellent results.

Edit:
A couple more before pictures. The shaved head is when I started treatment. The next one is grown out a couple months later in brighter light. Then two pics from the other day under neutral light and bright light, respectively. I took a month off treatment due to my travel schedule and some other factors. My scalp is healed and ready to begin needling again soon. It doesn't look like I lost any ground during the time off.

Amazing results! What kind of reactions have you had from friends, family, coworkers etc?