Have people on this forum been testing experimental drugs on themselves as frequently as they are now?

[eeyore]

I've just recently started really browsing these forums and potentially promising drugs seem to be PDRN (https://www.gourmetstylewellness.com/intera...wn-powerhouse-for-androgenic-alopecia.131171/) and the drug Bayer is working on (https://www.gourmetstylewellness.com/intera...for-male-and-female-pattern-hair-loss.127790/) among a few others.

Is it a normal thing for drugs looking this promising to be bought on the grey market and members of this forum testing it on themselves? Is this another one in a hundred/thousand things that have been tried and failed or are these actually a big deal and they might give us some regrowth?

 

[pegasus2]

PDRN is unlikely to do anything. There's been tons of things like that which didn't pan out. There have been some experimental compounds that worked out pretty well for some people, but it's always been thought to be impossible by most researches for a single compound to reverse hair loss. Many experimental compounds over the years have shown promising results in vitro. Bayer is the first one to show major reversal in vivo in an Androgenetic Alopecia model. Mouse studies are helpful in other ways, but the results don't translate to humans. Hair loss has been cured a thousand times in mice because mice don't have male pattern baldness. If you shave their fur it will grow back no matter what you apply. Bayer's compound was applied to macaques with male pattern baldness. Same as in humans nothing grows their hair back, but Bayer's compound did. This is the first time that's ever been seen.

To compare, BAY increase terminal hair count by 109% in macaques, and this is what latanoprost did in macaques: "Latanoprost at 500 ug/ml induced moderate to marked hair regrowth with 5–10% conversion of vellus hairs to intermediary or terminal hairs." Minoxidil and finasteride didn't do much better, if any. This is the first compound that's ever been able to regrow hundreds of hairs/cm² in a real male pattern baldness model. Latanoprost and minoxidil are the two most potent hair growth promoters on the market aside from estrogen. These results I quoted are pretty much the same as the latanoprost results observed in a human trial, so you can see that macaques are an excellent model for testing male pattern baldness drugs. RU58841 did very well in macaques, with a vellus to terminal conversion rate of 26% compared to 12% with finasteride. RU also did very well in doubling the number of anagen hairs, but most of those hairs were vellus.

 

[eeyore]

PDRN is unlikely to do anything. There's been tons of things like that which didn't pan out. There have been some experimental compounds that worked out pretty well for some people, but it's always been thought to be impossible by most researches for a single compound to reverse hair loss. Many experimental compounds over the years have shown promising results in vitro. Bayer is the first one to show major reversal in vivo in an Androgenetic Alopecia model. Mouse studies are helpful in other ways, but the results don't translate to humans. Hair loss has been cured a thousand times in mice because mice don't have male pattern baldness. If you shave their fur it will grow back no matter what you apply. Bayer's compound was applied to macaques with male pattern baldness. Same as in humans nothing grows their hair back, but Bayer's compound did. This is the first time that's ever been seen.

To compare, this is what latanoprost did to macaques: "Latanoprost at 500 ug/ml induced moderate to marked hair regrowth with 5–10% conversion of vellus hairs to intermediary or terminal hairs." Minoxidil and finasteride didn't do any better in macaques. This is the first compound that's ever been able to regrow hundreds of hairs/cm² in a real male pattern baldness model. Latanoprost and minoxidil are the two most potent hair growth promoters on the market aside from estrogen. These results I quoted are the same as the latanoprost results observed in a human trial, so you can see that macaques are an excellent model for testing male pattern baldness drugs.

Latanoprost is the same thing Bayer and Hope medicine are working on right? From the actual results in trials they have achieved so far it definitely seems like something to be excited about. Though not having followed experimental hair loss drugs until recently, I was wondering whether there were many different drugs like this with seemingly this level of potential or if it stands out among everything that never made it to commercialization.

 

[pegasus2]

Latanoprost is the same thing Bayer and Hope medicine are working on right? From the actual results in trials they have achieved so far it definitely seems like something to be excited about. Though not having followed experimental hair loss drugs until recently, I was wondering whether there were many different drugs like this with seemingly this level of potential or if it stands out among everything that never made it to commercialization.

No, latanoprost is on the market now for eyelashes. What Bayer and Hope medicine are working on is a monocolonal antibody mat3, known as HMI-115, formerly known as BAY-1158061. You came here at the right time because we've never seen anything like this before.

 

[TurboFixer]

No, latanoprost is on the market now for eyelashes. What Bayer and Hope medicine are working on is a monocolonal antibody mat3, known as HMI-115, formerly known as BAY-1158061. You came here at the right time because we've never seen anything like this before.

what are your thoughts on KY - seems to be a pretty substantial hypetrain for it

 

[polishkickbuttowski]

No, latanoprost is on the market now for eyelashes. What Bayer and Hope medicine are working on is a monocolonal antibody mat3, known as HMI-115, formerly known as BAY-1158061. You came here at the right time because we've never seen anything like this before.

Im too poor to be excited about this but I still am. I'll take temporary infertility for perfect hair.