GourmetStyleWellness
Senior Member
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gourmetstylewellness.com's Note: Unfortunately this is yet another herbal study that was done for only 3 months, and involved only Twelve people. Too short of a duration and way too few people to make any solid assessments. Interesting reading either way. Its funny that they pointed out there was no change in hair diameter. Well yeah. In 3 months that is crazy to expect. Maybe after 2 years of constant recycling in of hairs while on the treatment. Im disappointed that they as researchers didn't know this.
Objective:
Androgenic Alopecia, or male pattern baldness, is a common condition characterized by progressive miniaturization of hair follicles in specific scalp areas. This androgen-dependent condition frequently causes psychological distress but is poorly controlled. Xiantene, composed of 8 botanical extracts, stimulates the growth of isolated human hair follicles IN VITRO. Therefore, its effects on hair growth IN VIVO were assessed after topical application to the scalps of men with androgenic alopecia, in a 3-month pilot study.
Methods:
The investigation was conducted on a placebo controlled, double blind basis, involving 12 healthy men with androgenic alopecia. They were a II to a VI on the Hamilton scale and the mean age was 38.9 years. The Xiantene group applied 1ml of solution topically to the crown area each day; the control group used only the vehicle. Hair samples were epilated from an 8mm circle from each subject's scalp at the beginning and end of the study. The unit area trichogram method was used to compare various hair follicle parameters. Measurements were made using light microscopy linked to a computer and the results analyzed using Student's paired T test.
Results:
There were no significant changes in control group parameters. In the Xiantene group the mean total hair number and number of hairs in anagen were both significantly increased (16.3%, P=0.033; 23.7%, P=0.0003 respectively). No change is anagen hair diameter was detected. Although anagen hair pigmentation increased, this may be due to staining by the test material. Further clarification is required.
Conclusions
These results imply that topical application of the herbal mixture Xiantene is able to promote anagen and increase the length of the anagen phase in subjects with androgenic alopecia. This suggests that it could promote a cessation or reversal in the progression of androgenic alopecia. Although the mode of action is unknown, several components of Xiantene have exhibited enzyme inhibition properties and Xiantene may act as a 5ar inhibitor, blocking 5aDHT synthesis. A larger, longer investigation needs to be carried out to confirm these effects.
(duh)
Objective:
Androgenic Alopecia, or male pattern baldness, is a common condition characterized by progressive miniaturization of hair follicles in specific scalp areas. This androgen-dependent condition frequently causes psychological distress but is poorly controlled. Xiantene, composed of 8 botanical extracts, stimulates the growth of isolated human hair follicles IN VITRO. Therefore, its effects on hair growth IN VIVO were assessed after topical application to the scalps of men with androgenic alopecia, in a 3-month pilot study.
Methods:
The investigation was conducted on a placebo controlled, double blind basis, involving 12 healthy men with androgenic alopecia. They were a II to a VI on the Hamilton scale and the mean age was 38.9 years. The Xiantene group applied 1ml of solution topically to the crown area each day; the control group used only the vehicle. Hair samples were epilated from an 8mm circle from each subject's scalp at the beginning and end of the study. The unit area trichogram method was used to compare various hair follicle parameters. Measurements were made using light microscopy linked to a computer and the results analyzed using Student's paired T test.
Results:
There were no significant changes in control group parameters. In the Xiantene group the mean total hair number and number of hairs in anagen were both significantly increased (16.3%, P=0.033; 23.7%, P=0.0003 respectively). No change is anagen hair diameter was detected. Although anagen hair pigmentation increased, this may be due to staining by the test material. Further clarification is required.
Conclusions
These results imply that topical application of the herbal mixture Xiantene is able to promote anagen and increase the length of the anagen phase in subjects with androgenic alopecia. This suggests that it could promote a cessation or reversal in the progression of androgenic alopecia. Although the mode of action is unknown, several components of Xiantene have exhibited enzyme inhibition properties and Xiantene may act as a 5ar inhibitor, blocking 5aDHT synthesis. A larger, longer investigation needs to be carried out to confirm these effects.
(duh)
