HOW does DHT cause cancer?

[HARM1]

Is it because the more DHT we have the bigger the prostate is - more cells- more chance of one being cancers ? or is DHT a mutagen ?

 

[docj077]

Is it because the more DHT we have the bigger the prostate is - more cells- more chance of one being cancers ? or is DHT a mutagen ?

DHT binding to the androgen receptor in the prostate causes the activation of the prostate androgen-regulated (PAR) gene. I can't really find any information on the signaling pathway after that step, but apparently it leads to androgen independent prostate cancer cells and the subseqent hyperplasia, dysplasia, etc. So, that gene must be involved with genes that control cellular proliferation.

 

[abcdefg]

Another possible answer is no one knows. I promise you merk nor anyone else understands exactly what pathways, genes, and how everything at the molecular level is all related and what it is doing. If they did there would be very effective treatments or a complete cure. Finasteride is the 1990 era scientific "guess" going with what we know at the time which really isnt much. 50 years from now we will have a more advanced,accurate, and safer guess. The previous poster said some of our current theories.

 

[docj077]

Another possible answer is no one knows. I promise you merk nor anyone else understands exactly what pathways, genes, and how everything at the molecular level is all related and what it is doing. If they did there would be very effective treatments or a complete cure. Finasteride is the 1990 era scientific "guess" going with what we know at the time which really isnt much. 50 years from now we will have a more advanced,accurate, and safer guess. The previous poster said some of our current theories.

Actually, you are correct. Current studies demonstrate that the level of DHT in the prostate does not necessarily correlate with the Gleeson score given to any given instance of prostate cancer. I really don't think anyone knows the pathways or why some people are more susceptible.

Everything you typed there is very, very true.

 

[HARM1]

Is it because the more DHT we have the bigger the prostate is - more cells- more chance of one being cancers ? or is DHT a mutagen ?

DHT binding to the androgen receptor in the prostate causes the activation of the prostate androgen-regulated (PAR) gene. I can't really find any information on the signaling pathway after that step, but apparently it leads to androgen independent prostate cancer cells and the subseqent hyperplasia, dysplasia, etc. So, that gene must be involved with genes that control cellular proliferation.

"ut apparently it leads to androgen independent prostate cancer cells and the subseqent "
So youre saying DHT is a mutagen?

 

[docj077]

Is it because the more DHT we have the bigger the prostate is - more cells- more chance of one being cancers ? or is DHT a mutagen ?

DHT binding to the androgen receptor in the prostate causes the activation of the prostate androgen-regulated (PAR) gene. I can't really find any information on the signaling pathway after that step, but apparently it leads to androgen independent prostate cancer cells and the subseqent hyperplasia, dysplasia, etc. So, that gene must be involved with genes that control cellular proliferation.

"ut apparently it leads to androgen independent prostate cancer cells and the subseqent "
So youre saying DHT is a mutagen?

Not directly, but bound to it's receptor it sure isn't a good thing as it will cause the transcription of certain genes that may lead to cancer. It does not induce mutations in the DNA. It merely encourages genes to be overexpressed.

 

[HARM1]

I finasteride used to treat prostate caner? ( or dutasteride)

 

[docj077]

I finasteride used to treat prostate caner? ( or dutasteride)

Neither. Chemical castration or prostatectomy are the only answers, but I believe that either of those drugs may be used for the unexplainable androgens that seem to stick around even after castration is performed.

I can sure look it up if you want me to. I have access to mdconsult, which is pretty much the premier site for doctors. It's rare to see a physician that doesn't use it nowadays.

 

[HARM1]

I finasteride used to treat prostate caner? ( or dutasteride)

Neither. Chemical castration or prostatectomy are the only answers, but I believe that either of those drugs may be used for the unexplainable androgens that seem to stick around even after castration is performed.

I can sure look it up if you want me to. I have access to mdconsult, which is pretty much the premier site for doctors. It's rare to see a physician that doesn't use it nowadays.

Are you learning med?
I would like to know if people with no 5AR- 2 OR people WITH androgen insensitive to andogens ever get Prostate cacncer

 

[docj077]

I finasteride used to treat prostate caner? ( or dutasteride)

Neither. Chemical castration or prostatectomy are the only answers, but I believe that either of those drugs may be used for the unexplainable androgens that seem to stick around even after castration is performed.

I can sure look it up if you want me to. I have access to mdconsult, which is pretty much the premier site for doctors. It's rare to see a physician that doesn't use it nowadays.

Are you learning med?
I would like to know if people with no 5AR- 2 OR people WITH androgen insensitive to andogens ever get Prostate cacncer

That's a really good question. I know that lately they found a virus that infects some people with prostate cancer. That would be a fascinating discovery if that turned out to be true. However, I have no idea on that one. I could look. Let me check.

 

[Bryan]

I would like to know if people with no 5AR- 2 OR people WITH androgen insensitive to andogens ever get Prostate cacncer

Nope.

 

[HARM1]

I would like to know if people with no 5AR- 2 OR people WITH androgen insensitive to andogens ever get Prostate cacncer

Nope.

both of them don't get prostate cancer? hmm
Then is it known how DHT causes cancer?

 

[Rage]

Then is it known how DHT causes cancer?

DHT does not "cause" cancer. Cancers have the following attribute:

1. They are more resistant to death

2. They spread to other areas

3. They have heightened proliferation

Cancer cells don't just gain the above effects out of nothing, they gain them by mutations in genes that naturally control those effects. Proliferation is controlled by growth factors, with molecules such as epidermal growth factors, estrogen and DHT. You'll also notice that these molecules are all linked with cancer.

Growth factors, like DHT, don't "cause" cancer but are often linked because they are genetically pre-encoded proliferation enhancers. When the gene is damaged and become abnormally active, you get cancer.

 

[HARM1]

Then is it known how DHT causes cancer?

DHT does not "cause" cancer. Cancers have the following attribute:

1. They are more resistant to death

2. They spread to other areas

3. They have heightened proliferation

Cancer cells don't just gain the above effects out of nothing, they gain them by mutations in genes that naturally control those effects. Proliferation is controlled by growth factors, with molecules such as epidermal growth factors, estrogen and DHT. You'll also notice that these molecules are all linked with cancer.

Growth factors, like DHT, don't "cause" cancer but are often linked because they are genetically pre-encoded proliferation enhancers. When the gene is damaged and become abnormally active, you get cancer.

So how do men with no or very little DHT in their prostate, never get prostate cancer?

 

[maddoc23]

DHT does not cause cancer.
Finasteride and other 5alpha blockers are being studied right now to prevent prostate cancer, but there has not been any definitive data released from those results. Prostate cancer occurs because as men age their prostate grows. Whenever cells divide they have a higher rate of mutation. These mutations tend to lead to cancer. DHT is a known trophic hormone of the prostate, thus why its being looked at to prevent prostate cancer

D

 

[HARM1]

DHT does not cause cancer.
Finasteride and other 5alpha blockers are being studied right now to prevent prostate cancer, but there has not been any definitive data released from those results. Prostate cancer occurs because as men age their prostate grows. Whenever cells divide they have a higher rate of mutation. These mutations tend to lead to cancer. DHT is a known trophic hormone of the prostate, thus why its being looked at to prevent prostate cancer

D

Are you saying that DHT only increases the chance for fancer because of more cell dividing ?
again, how do you respond to the fact that men with no or very little DHT in their prostate, never get prostate cancer?

 

[docj077]

DHT does not cause cancer.
Finasteride and other 5alpha blockers are being studied right now to prevent prostate cancer, but there has not been any definitive data released from those results. Prostate cancer occurs because as men age their prostate grows. Whenever cells divide they have a higher rate of mutation. These mutations tend to lead to cancer. DHT is a known trophic hormone of the prostate, thus why its being looked at to prevent prostate cancer

D

DHT is not required once the cellular response becomes autocrine. 5AR blockers are ineffective once this occurs and infact chemical castration will be ineffective, as well. Thus, DHT is not required once cancer develops

BPH, however, is a different story and requires DHT to maintain the prostate volume and denstiy. BPH is a normal histological finding related to aging as you said.

DHT can cause cancer indirectly through inappropriate hyperplasia of prostate cells followed by the development of dysplasia as mutations accumulate.

 

[docj077]

DHT does not cause cancer.
Finasteride and other 5alpha blockers are being studied right now to prevent prostate cancer, but there has not been any definitive data released from those results. Prostate cancer occurs because as men age their prostate grows. Whenever cells divide they have a higher rate of mutation. These mutations tend to lead to cancer. DHT is a known trophic hormone of the prostate, thus why its being looked at to prevent prostate cancer

D

Are you saying that DHT only increases the chance for fancer because of more cell dividing ?
again, how do you respond to the fact that men with no or very little DHT in their prostate, never get prostate cancer?

You sort of explained it to yourself. No DHT means no hyperplasia. No hyperplasia means no accumulation of mutation. No accumulation of mutation means no cancer.

 

[HARM1]

DHT does not cause cancer.
Finasteride and other 5alpha blockers are being studied right now to prevent prostate cancer, but there has not been any definitive data released from those results. Prostate cancer occurs because as men age their prostate grows. Whenever cells divide they have a higher rate of mutation. These mutations tend to lead to cancer. DHT is a known trophic hormone of the prostate, thus why its being looked at to prevent prostate cancer

D

Are you saying that DHT only increases the chance for fancer because of more cell dividing ?
again, how do you respond to the fact that men with no or very little DHT in their prostate, never get prostate cancer?

You sort of explained it to yourself. No DHT means no hyperplasia. No hyperplasia means no accumulation of mutation. No accumulation of mutation means no cancer.

Hello friend ! Could you show me that this is what the medical world belives in ?
I don't get a few things:
With no dht or very little dht prostate prostate cell still duplicate, no? So cancer can still happen. maybe in a much less chance, but still a chance. maybe because of the low rate, then is is belived that this people never get it.
what do you say?

 

[docj077]

DHT does not cause cancer.
Finasteride and other 5alpha blockers are being studied right now to prevent prostate cancer, but there has not been any definitive data released from those results. Prostate cancer occurs because as men age their prostate grows. Whenever cells divide they have a higher rate of mutation. These mutations tend to lead to cancer. DHT is a known trophic hormone of the prostate, thus why its being looked at to prevent prostate cancer

D

Are you saying that DHT only increases the chance for fancer because of more cell dividing ?
again, how do you respond to the fact that men with no or very little DHT in their prostate, never get prostate cancer?

You sort of explained it to yourself. No DHT means no hyperplasia. No hyperplasia means no accumulation of mutation. No accumulation of mutation means no cancer.

Hello friend ! Could you show me that this is what the medical world belives in ?
I don't get a few things:
With no dht or very little dht prostate prostate cell still duplicate, no? So cancer can still happen. maybe in a much less chance, but still a chance. maybe because of the low rate, then is is belived that this people never get it.
what do you say?

Increased circulating estrogens due to obesity are one cause and any disease process that increases insulin levels as insulin has affinity for the IGF-1 receptor on prostate cells. Also, high energy and protein intake has also been assoicated with BPH.

So, there are numerous other causes for BPH and then prostate cancer to occur.