How Long Until A "cure" Or Full Reversal Treatment?

[NimuDash]

I've been slightly obsessed with hair loss research lately so here is my take on it... A cure probably won't come for a while. one single event to cure hairloss (whether that is a procedure like tsuji, gene editing, etc) is probably something like 7-10 years away. BUT, new TREATMENTS that will most likely help to recover one, two, maybe even three norwoods look likely to succeed within the next few years. You have shisiedo, follica, fevipiprant, and the broztu lotion which are all set to be released either in 2018 or 2019. Even with unexpected delays, this is relatively soon. A full "cure" or reverasal of hairloss to bring a NW7 back to a 1 seems likely (to me) to be out in under 10 years. With that being said, this thread is kind of redundant because for many people these new treatments will be a cure. So in the meantime hang on to what you have with current treatments and ride this out because this sh*t storm of a disease will be over sooner than we know it. I know that people have been saying a cure is coming "in 10 years!" for decades and decades, but today we actually have scientific evidence and developments backing these claims. End rant

They'll burn people alive here for such positivity, sometimes they can tell you to stick your positivity deep into your own ***. These people, these baldies, they are:

 

[ZenHead]

I really hope this is true. Right now I'm still making gains with treatments, so if I can just hold on another 5 years hopefully a new treatment that's effective will be out. Crossing my fingers.

I think you should be fine, especially if you've been losing hair for under 5 years. Some people have been seeing massive success with Setipiprant (a weaker PGD2 receptor inhibitor than Fevipiprant) in terms of maintenance and thickening. That's the one I'm most excited about because fevi is coming out in 2019 for asthma, which people actually give a sh*t about unlike male pattern baldness

 

[Trouse]

What are you talking about ? dismal future? wtf man? Do you even understand the progress of technology? Every year we get to know something knew, computers are getting faster, algorithms are improving, so even if TSUJI, shiseido, or those korean guys fail, it's inevitable for cure to come. In like 7-10 years machine learning will be so powerful that it will be mapping genes and finding the ones we need to remove. IT IS INEVITABLE FOR CURE TO COME. Only guys who don't understand progress of technology says that there won't be anything for 10 or more years.

What you're saying isn't wrong, it's just more applicable to things like TVs, phones, cars - you know, ordinary tech. Bio-tech is a different ballgame altogether. The discovery is only half the battle and the real holdups come with implementing this newly acquired knowledge in a way that satisfies a government's safety and regulatory standards. In the U.S, that red tape is very real and very cumbersome. Computing capabilities may increase exponentially but that stuff is all working within defined parameters - the human body is way more complex and has more variables and is thus more dangerous to "experiment" on. Hence the insistence on mice and rat models still. Despite what you take away from Youtube videos, genetic engineering like CRISPR is still pretty far off.

To be clear, I do think that a non-invasive, full-blown cure for hair-loss should be within reach in our lifetimes. With tremendous luck, it could happen in twenty years maybe. Not that that benefits anyone on this website, but still.

 

[ZenHead]

They'll burn people alive here for such positivity, sometimes they can tell you to stick your positivity deep into your own ***. These people, these baldies, they are:

I'm hoping to not be burned at the stake for my positivity... gotta be careful on these forums

 

[Dontwannabeabetabob]

I think you should be fine, especially if you've been losing hair for under 5 years. Some people have been seeing massive success with Setipiprant (a weaker PGD2 receptor inhibitor than Fevipiprant) in terms of maintenance and thickening. That's the one I'm most excited about because fevi is coming out in 2019 for asthma, which people actually give a sh*t about unlike male pattern baldness

I've heard of both. You think doctors would prescribe fevi for male pattern baldness too?

 

[ZenHead]

I've heard of both. You think doctors would prescribe fevi for male pattern baldness too?

No, probably not. But when a new drug is released on the market it doesn't take long for generics to release shortly after. You can get setipiprant now though, but its pretty expensive.

 

[Maxxorr]

I'm hoping to not be burned at the stake for my positivity... gotta be careful on these forums

burn!

 

[razzmatazz91]

I think you should be fine, especially if you've been losing hair for under 5 years. Some people have been seeing massive success with Setipiprant (a weaker PGD2 receptor inhibitor than Fevipiprant) in terms of maintenance and thickening. That's the one I'm most excited about because fevi is coming out in 2019 for asthma, which people actually give a sh*t about unlike male pattern baldness

No, probably not. But when a new drug is released on the market it doesn't take long for generics to release shortly after. You can get setipiprant now though, but its pretty expensive.

When is Seti likely to be out, officially, for alopecia?
Haven't heard of this drug before. I've been balding for less than five years, but didn't maintain on finasteride. Heavily diffused at this point, but I would be happy with a very small improvement a this point.

EDIT: Just found this: https://clinicaltrials.gov/ct2/show/record/NCT02781311?intr=ACT-129968+OR+Setipiprant

Thoughts?

 

[ZenHead]

Seti 2021 fevi 2019.

 

[H]

Why not? have you never seen an animal regrowing fur after a big wound? And that is way beyond human's hair density. Technology is moving fast. People who claim that we won't have cure in 30 years or our lifetimes are just uneducated..

Hmm an animal regrowing hair after being wounded = gene editing will completely reverse male pattern baldness... How many times have you watched the Amazing Spiderman?

 

[inmyhead]

Hmm an animal regrowing hair after being wounded = gene editing will completely reverse male pattern baldness... How many times have you watched the Amazing Spiderman?

Yes it's sucks that it's impossible to be travel faster than Cheetah or rise higher than a falcon.. oh wait... Dude like what the f*** lol? Wounding is getting ore and more research and you are hitting me about that... Like it's mathematically impossible to manage wnt pathways and proteins with gene editing or something.

 

[razzmatazz91]

Yes it's sucks that it's impossible to be travel faster than Cheetah or rise higher than a falcon.. oh wait... Dude like what the f*** lol? Wounding is getting ore and more research and you are hitting me about that... Like it's mathematically impossible to manage wnt pathways and proteins with gene editing or something.

On a side note, @inmyhead what's your take on derma rolling/micro needling?

 

[inmyhead]

On a side note, @inmyhead what's your take on derma rolling/micro needling?

You shouldn't be asking my opinion, i'm not the guy who spents most of his time researching hairloss studies. Anyways, there area some studies claiming wounding to be effect (especially that new, (was it asian? ) study, claiming that needling was more effective than minoxidil)) I've tried dermarolling myself without anything to see. Now I got derminator and the wounds seem to be better, so we will see how it goes. I'm experimenting on my most diffused side,

 

[H]

Yes it's sucks that it's impossible to be travel faster than Cheetah or rise higher than a falcon.. oh wait... Dude like what the f*** lol? Wounding is getting ore and more research and you are hitting me about that... Like it's mathematically impossible to manage wnt pathways and proteins with gene editing or something.

Regrowing organs by switching a few codons?... I don't think that will work.

 

[abcdefg]

Does anyone know when we are going to see the results of any study on the effects of PGD2 inhibitors? Like percentage of men they work on, and how well they work?

 

[NewUser]

How Long Until A "cure" Or Full Reversal Treatment?

Two words, Lowry and Christofk. Drugs will eventually grow hair on our head as well as sensorineural hairs in our cochlea to treat deafness. "Tha cure" will probably be a topical cream or ointment. Next to skin, HF are among the most accessible organs in our bodies. Scientists have figured out a way to activate stem cells in mice skin to grow hair, and it's just a matter of time before they do it humans. Two new drugs never tried in humans were patented recently.

 

[Trichosan]

I can't fathom how any topical will reactivate long inactive follicles. It would seem to me that the only sure cure would be follicular cloning or injection of genetically modified stem cells or combination of both. (?)

 

[Chap1]

Two words, Lowry and Christofk. Drugs will eventually grow hair on our head as well as sensorineural hairs in our cochlea to treat deafness. "Tha cure" will probably be a topical cream or ointment. Next to skin, HF are among the most accessible organs in our bodies. Scientists have figured out a way to activate stem cells in mice skin to grow hair, and it's just a matter of time before they do it humans. Two new drugs never tried in humans were patented recently.

I can't fathom how any topical will reactivate long inactive follicles. It would seem to me that the only sure cure would be follicular cloning or injection of genetically modified stem cells or combination of both. (?)

Interesting, I am not sure how a topical would work, but a drug or injection is something I can see. What were the two drugs patented recently?

 

[NewUser]

I can't fathom how any topical will reactivate long inactive follicles. It would seem to me that the only sure cure would be follicular cloning or injection of genetically modified stem cells or combination of both. (?)

Already drugs look to be the first legit treatment for AA and perhaps AT and AU, three incredibly difficult hairloss disorders to treat. That is until now. Angela Christiano's eureka moment in the lab has resulted in Aclaris buying the rights to her jakinib research.

Another company says they believe they can re-grow sensorineural "hairs" in cochlea of deaf people. Frequency Therapeutics, a startup biotech emerged from MIT research, have used a drug cocktail to stimulate the Wnt pathway in mice and generating a large pool of progenitor cells. A second drug caused these cells to differentiate into mature "hair" cells. Sensorineural hair cells don't normally re-grow, like scalp hair. Once your hearing cells break off from being exposed to loud noises or just aging in general, they don't grow back. They are doing this with drugs in lab tests, and human trials are months away.

I think drugs will be used to treat a lot of diseases in the near to mid term. Once they understand the genetic mutations, scientists don't necessarily have to replace or edit the defective gene if they can change the way it codes for proteins or enzymes simply by trying different drugs. And apparently they've already patented two drugs that increase lactate production in the scalp and, in turn, activate stem cells for hair growth.

I think Tsuji's method will be important for people with scarring alopecias and burn victims, cancer patients etc. To be sure, we want Tsuji to succeed. But for hundreds of millions of people with ordinary pattern hair loss, I think drugs will be the most cost-effective treatment.

 

[That Guy]

I can't fathom how any topical will reactivate long *inactive follicles

*or dead

Spoilers: It won't.

Already drugs look to be the first legit treatment for AA and perhaps AT and AU, three incredibly difficult hairloss disorders to treat. That is until now. Angela Christiano's eureka moment in the lab has resulted in Aclaris buying the rights to her jakinib research.

Another company says they believe they can re-grow sensorineural "hairs" in cochlea of deaf people. Frequency Therapeutics, a startup biotech emerged from MIT research, have used a drug cocktail to stimulate the Wnt pathway in mice and generating a large pool of progenitor cells. A second drug caused these cells to differentiate into mature "hair" cells. Sensorineural hair cells don't normally re-grow, like scalp hair. Once your hearing cells break off from being exposed to loud noises or just aging in general, they don't grow back. They are doing this with drugs in lab tests, and human trials are months away.

I think drugs will be used to treat a lot of diseases in the near to mid term. Once they understand the genetic mutations, scientists don't necessarily have to replace or edit the defective gene if they can change the way it codes for proteins or enzymes simply by trying different drugs. And apparently they've already patented two drugs that increase lactate production in the scalp and, in turn, activate stem cells for hair growth.

I think Tsuji's method will be important for people with scarring alopecias and burn victims, cancer patients etc. To be sure, we want Tsuji to succeed. But for hundreds of millions of people with ordinary pattern hair loss, I think drugs will be the most cost-effective treatment.

100%, freshly-squeezed, no artificial flavours or colouring added COPE!

There is absolutely no reason whatsoever to believe Androgenetic Alopecia can or will in the foreseeable future be cured by topical drugs alone. They haven't been for decades despite literally hundreds of things being discovered that worked on mice.

You know it, I know it, the entire pharmaceutical industry knows it, and so on.

AA, Totalis, etc. are completely different diseases. So the logic of "well drugs cured that so there!" falls flat on its face.

There is still presently nothing that indicates human scalp hair can or could be regrown in its original pattern by means of some simple drugs administered topically; it's just not enough.

You hope that drugs will cure it because it's "cost effective" and you don't want or are possibly afraid of some type of surgery or wounding therapy that will be more invasive and expensive.

But reality is not concerned with cost efficiency or what people would prefer; it's about what is possible. Currently, all research that has worked to grow new hair involves either wounding or an in-vitro manipulation of various cell types. I know it's shocking, but regrowing full-functioning organs is going to be a lot more difficult than slathering some jojoba oil on your skull and I don't know how many more millions of dollars, hours and years will have to be wasted before this sinks in to the majority of researchers because even a layman can see this sh*t isn't working.

We'd have had the cure by now if people just stopped pissing around with trying to find some wonder drug.