Hypothesis

[waynakyo]

I would be interested in the full text, since it discusses the relation between dht and pgd2


http://www.ncbi.nlm.nih.gov/pubmed/24548754
[FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Androgenic alopecia, a condition characterized by increased levels of DHT could have been selected for due to the benefits that prostaglandin D2 (PGD(2)) has on the prostate. A DHT metabolite can increase the transcription of prostaglandin D2 synthase through estrogen receptor beta. The increase of PGD(2) can decrease the risk of prostate cancer and proliferation of prostate cancer cells. Therefore, the mechanisms behind male pattern baldness may also curtail the advancement of prostate cancer.[/FONT]

 

[Armando Jose]

Bhargava S.
[h=3]Author information[/h]

• Cornell University, Ithaca, NY, USA. Electronic address: [email protected].

 

[frenchy]

i can mail you this paper if you want

 

[Armando Jose]

i can mail you this paper if you want

Please, I am too interested in this paper.

 

[frenchy]

yeah PM me your email adresses cauz i don't think it's legal to post this paper here

 

[Ventures]

And is there some kind of correlation between male pattern baldness and BPH ? How many percentage of patients which suffer BPH have Androgenetic Alopecia ?

It would be interesting to see those results ?

 

[IDW2BB]

And is there some kind of correlation between male pattern baldness and BPH ? How many percentage of patients which suffer BPH have Androgenetic Alopecia ?

It would be interesting to see those results ?

I would characterize severity of Androgenetic Alopecia. Don't 70%-80% of all men experience Androgenetic Alopecia in some severity based on age?

 

[IDW2BB]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104038/

 

[I.D WALKER]

:woot: What are you trying to do ID, incite a virtual riot? LOL. I confess I only skimmed the abstract. Nonetheless if the study findings prove to "hold up" to peer scrutiny, it simply reverberates the clarion call from all concerned or interested members, for a comparably effective alternative topical ie; finasteride. and dutasteride. Thanks for the share. Your personal/professional input would also be appreciated.

 

[IDW2BB]

Certainly is an interesting topic to read up on.

http://www.ncbi.nlm.nih.gov/pubmed/24823464

http://www.ncbi.nlm.nih.gov/pubmed/8408229

 

[Armando Jose]

very good study, 5 alfa reductase type 1 and insulin sensitivity...., good work

 

[IDW2BB]

very good study, 5 alfa reductase type 1 and insulin sensitivity...., good work

Speaking of sensitivity, overcoming inflammation might be a bigger hurdle than we realize. Total speculation on my part, but it just makes sense to me that where there is inflammation in the body there is cortisol trying to resolve it. Constant inflammation= constant cortisol.

I wonder if the cells could somehow become resistant to cortisol similar to insulin? If they do, that could be the reason it's so tough to resolve. Then there is the issue of clearing all that cortisol.

Anyway, total speculation on my part regarding the connection between cortisol, organ regeneration (liver and hair), and inflammation. Could be nothing, just thinking out loud.

 

[I.D WALKER]

http://www.sciencedaily.com/releases/2013/04/130403200156.htm http://www.medicinenet.com/script/main/art.asp?articlekey=119453

 

[IDW2BB]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547054/

 

[Future_HT_Doc]

I think you would see major issues/obvious signs that cells were becoming resistant to cortisol.

Take the above example you mentioned:

In type II diabetes mellitus (DM II), continually elevated levels of blood glucose lead to subsequently elevated levels of blood insulin, and an eventually dulling of tissue receptors to insulin (which is responsible for bringing the glucose out of the tissues and into muscle cells, fat cells, liver cells, etc). This imbalance causes a variety of of symptoms - both from the elevated sugar and elevated insulin - and create serious disease.

If cells became resistant to cortisol, I think you would have something similar - that is, serious systemic signs of endocrine disease. It would probably look similar to a patient with Addison's disease (adrenal/cortisol production insufficiency).

Interesting thought though! I also definitely think there is a correlation between DM - especially DM type I - and alopecia.