I am scared because of post finasteride syndrome…
- Thread starter Ufz-h
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Did you quit because of PFS?
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You should. Ask yourself this question, Why GSK in 2002 did a great phase 2 on dutasteride , far superior than finasteride in results, but they never did a phase 3 in USA and never release it for Androgenetic Alopecia ? Merck do something very unmoral in release an SYSTEMIC 5-alpha-reductase inhibitor cause basic 2 things :
1) You are not only inhibitin DHT you are inhibiting many other reactions since 5-alpha-reductase is part of many other reactions
2) DHT and important hormone, if you should block it, you should block it topically, locally and not in the entire body . Do they did any study showing any health placebo controlled group in a long period of time ? What happen after 10 years of DHT suppresion in general health ? 20 years , 30 years ? Finasteride is approved almost 30 years ago for Prostate , and 25 years ago for Androgenetic Alopecia. Why not a single phase 4 ( after comercial ) done by Merck showing not just the " keep hair " but not even hormones values like estradiol, progesterone, etc ?
Minoxidil plus tretinoin ( read the studies on pubmed ) plus ketoconazole shampoo ( leave it for 20 minutes every day ) . that should be enought for almost everyone with Androgenetic Alopecia.
Keep ignoring the facts like it was 1997 , is not smart . Merck told us all lies , like they did with Vioxx .
This is wrong, however don’t read propeciahelp.com those stories are possibly exaggerated.
Thank you for that in depth response! I will look into all of that
I quit because the shed was outrageous for 7 months. A had some low libido while taking the drug but felt fine otherwise. Libido and mood crashed when I came off the drug. I’m fine now.
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5-alpha reductase is used by the body to convert pregnolone into allopregnolone. So You was inhibiting also allopregnolone which cause depression .
Worst part is that most people here will tell you " it was just psychological "
5-alpha reductase is know that is part of at least another 6 reactions in the body. We are in 2021 , some people still buy the sh*t of the propaganda from the 90s created by Merck. Now we have at least 25 more years of science knowledge . There is not a single hormone in the boy or enzyme that it is produce it in normal range that you can inhibit it a 70 % and not cause side effects. You can't even do that with cholesterol .
The problem is not DHT, the problem is our damn follicles sensible to it. DHT and most important, 5-alpha reductase, it is necesary for a male .
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Why is finasteride FDA approved if it is so horrific for you?
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First of all claiming Dutasteride is "far superior than finasteride", is just plain wrong at most it can produce marginally better hair outcomes. To answer why Dutasteride didn't progress into phase 3 is quite simple. We know it isn't because of side effects as the incidence isn't any higher than finasteride when looking at clinical RCT data, so you can bet GSK management knew full well they'd very likely gain marketing authorisation from regulators should they have chosen to progress to trials. What likely caused them to cease funding was just down to it under performing in their eyes, not producing outcomes that were that much better than finasteride and with Propecia seen as a commercial failure by analyst at the time the financial risk would have been to high.
Definitely not worth it. PFS is true.
And the possibility of Finasteride making your hair worse instead of better + getting PFS which may be irreversible is the reason I would never advise it.
Rather stick to stuff like Minoxidil + Microneedling until 2023 when Breezula and Kintor Pharmaceuticals treatment called Pyrilutamide comes out and does what Finasteride wished it could do and probably without the side effects.
Because the pharmaceutical industry like every industry in the world has corruption.
It's all ruled by money.
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Lack of clinical evidence that would suggests it is as dangerous as hysterical forum users would have us believe.
If you get sides from Finasteride which blocks less DHT than Dutasteride, and keeping in mind the blocking of DHT is the main cause of side effects, most people who do get sides in Finasteride are likely to get sides from Dutasteride as well, if not worse. But not everyone.
There's loads of Clinical evidence nowadays saying how bad Finasteride is.
A ton of studies have been posted here, take your time to read them.
There's even screenshots of verified* medical doctors on Twitter talking to other verified doctors on Twitter about how bad Finasteride can be and the side effects being common.
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I've already read enough of the major post approval clinical trials that have been published in the past 2 decades to know what a total nothing burger all this is which explains why PFS advocates have to appeal to empty claims of corruption instead of evidence.
Clearly you haven't read a word I said or the links with new evidence. If your comment was even worth a second thought you'd know the evidence in recent years are incomparable to those 2 decades ago when almost no one was speaking out against Finasteride relatively.
As I said, even verified* Medical Doctors on Twitter attested to the real side effects of Finasteride.
Wouldn't have seen that 2 decades ago when Google only launched in 1999 and most hairloss forums only launched around less than 10 years ago.
Also, we wouldn't have seen these tweets from verified MD's on Twitter when Twitter only launched in 2006. It takes many many years for groups to form and speak up and do further studies about how real and frequent the side effects of Finasteride are.
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