docj077
Senior Member
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Bryan is very correct on this one. IGF-1 is necessary for proper follicular proliferation and differentiation. As a molecule, it is 99% protein bound. What makes reducing it rather futile is the fact that it's made by not only the liver, but also in an autocrine/paracrine fashion within peripheral tissues such as bone. The peripherally synthesized molecule often "leaks" into the systemic circulation, as well.
Autocrine/paracrine IGF-1 can stimulate local, unbalanced growth independent independent of systemic growth hormone levels. This is made obvious during wound healing.
More importantly, GH, IGFBP-3 and ALS form a ternary complex. Reduce one and you'll reduce IGF-1. What's more important to note is that if IGF-1 levels are increased and associated with hair loss, then it would lend one to believe that all individuals with acromegaly will have hair loss. This is not the case. Another important point is that IGF-1 is required for muscle maintenacne. Lastly, it's very, very important that everyone here understand that propecia raises IGF-1 levels in the scalp, which is quite likely a measure of the effectiveness of treatment at the follicular level.
Autocrine/paracrine IGF-1 can stimulate local, unbalanced growth independent independent of systemic growth hormone levels. This is made obvious during wound healing.
More importantly, GH, IGFBP-3 and ALS form a ternary complex. Reduce one and you'll reduce IGF-1. What's more important to note is that if IGF-1 levels are increased and associated with hair loss, then it would lend one to believe that all individuals with acromegaly will have hair loss. This is not the case. Another important point is that IGF-1 is required for muscle maintenacne. Lastly, it's very, very important that everyone here understand that propecia raises IGF-1 levels in the scalp, which is quite likely a measure of the effectiveness of treatment at the follicular level.