I'm going thin .... but my brother ain't ..... WTF !!

[Perfectionist]

Isn't hairloss supposed to run in families ??

My fathers side has no hair loss in the family

My mother has almost every male member in her family going bald

Does that mean I will definitely go bald too .....

In which case why is my brother (2 years younger than me) still got a full head of hair !!

 

[amibald]

Isn't hairloss supposed to run in families ??

My fathers side has no hair loss in the family

My mother has almost every male member in her family going bald

Does that mean I will definitely go bald too .....

In which case why is my brother (2 years younger than me) still got a full head of hair !!

not necessarily, i dont think everyone is going to have hairloss, i remember my grandad, my mum's dad at 67 still has a full head of hair, while his brother, who is still alive and probably like 72 or 73 is bald, not completely, but last time i saw him he had a receding hairline and had the male pattern baldness hairloss.

 

[docj077]

Your mom has two x chromosomes. You just had a 50% chance of getting the bad one.

 

[htownballa]

Your mom has two x chromosomes. You just had a 50% chance of getting the bad one.

so ur saying the male pattern baldness gene is only on the X chromosome?

 

[Apoc]

Yes if the chromosome shaped like an elephant you will go bald and grow huge ears when you get older. But if it's shaped like a bear then you will keep your hair but you will have a hairy ***.

 

[s.a.f]

Your families genetics are totally random it can come from either parents side and even skip generations. For the perfect example just look at the Royal family a real mixed bag:
Prince Charles - Fine until about 40 then started losing it now a combover and bald crown.
Prince Andrew - In his 40's now, no problems at all.
Prince Edward - Started losing it in his early 20's, full nw6 by age 30.
Prince Williiam - Started receeding at about 21 now thinning all over especialy crown, (probably on propecia now)
Prince Harry - Full head of thick hair.

 

[docj077]

Your mom has two x chromosomes. You just had a 50% chance of getting the bad one.

so ur saying the male pattern baldness gene is only on the X chromosome?

No, I'm just saying that it's very likely that the androgen receptor could be the source of his problem while not being a problem for his brother. Everyone is different and he wanted an answer.

There are numerous other sources. Upregulation of the 5AR type II gene on chromosome 2 which would could be an autosomal dominant or an autosomal recessive trait. One's propensity to undergo follicular fibrosis and collagen deposition due to a weak or strong immune response if it's due to inflammation in the first place.

There are many causes. It's just a simple answer for him, but only a genetics test costing thousands of dollars would tell him for sure.

 

[Hans Gruber]

Your families genetics are totally random it can come from either parents side and even skip generations. For the perfect example just look at the Royal family a real mixed bag:
Prince Charles - Fine until about 40 then started losing it now a combover and bald crown.
Prince Andrew - In his 40's now, no problems at all.
Prince Edward - Started losing it in his early 20's, full nw6 by age 30.
Prince Williiam - Started receeding at about 21 now thinning all over especialy crown, (probably on propecia now)
Prince Harry - Full head of thick hair.

yea but prince harry has a different father,James Hewitt :hairy:

 

[Aplunk1]

Haha... now this is getting interesting.

 

[Perfectionist]

So male hairloss is passed on through females ? ! Why and WTF ? !

Why does evolution hate head hair so much anyway ? !

Surely it is body hair that is not required anymore and should be slowly breeding out .....

God damn DNA !!

 

[docj077]

So male hairloss is passed on through females ? ! Why and WTF ? !

Why does evolution hate head hair so much anyway ? !

Surely it is body hair that is not required anymore and should be slowly breeding out .....

God damn DNA !!

The androgen receptor is on the X chromosome that you get from your mom. The 5alpha reductase type II enzyme gene is on chromosome 2, so you get that from both parents. 5alpha reductase type I enzyme gene is on chromosome 5, which means you also get it from both parents.

After testosterone is converted to DHT, binds to the receptor, and is internalized into a cell to move on into the nucleus, the result is pretty much based upon your immune response and your body's ability to handle the downstream chemical mediators that seem to cause perifollicular fibrosis, collagen deposition, and in some people possible venous stasis or lymphedema.

 

[htownballa]

So male hairloss is passed on through females ? ! Why and WTF ? !

Why does evolution hate head hair so much anyway ? !

Surely it is body hair that is not required anymore and should be slowly breeding out .....

God damn DNA !!

The androgen receptor is on the X chromosome that you get from your mom. The 5alpha reductase type II enzyme gene is on chromosome 2, so you get that from both parents.
After testosterone is converted to DHT, binds to the receptor, and is internalized into a cell to move on into the nucleus, the result is pretty much based upon your immune response and your body's ability to handle the downstream chemical mediators that seem to cause perifollicular fibrosis, collagen deposition, and in some people possible venous stasis or lymphedema.

Doctor are you sure the DHT receptor is only the X chromosome? Also can you explain what you mean by perifollicular fibrosis, collagen deposition, and lymphedema and how exactly this miniturizes hair.

PS The androgen receptor is in the cell and not on the surface so the DHT diffuses in. Then I'm guessing the complex leads to fibrosis etc...?

 

[Perfectionist]

So male hairloss is passed on through females ? ! Why and WTF ? !

Why does evolution hate head hair so much anyway ? !

Surely it is body hair that is not required anymore and should be slowly breeding out .....

God damn DNA !!

The androgen receptor is on the X chromosome that you get from your mom. The 5alpha reductase type II enzyme gene is on chromosome 2, so you get that from both parents. 5alpha reductase type I enzyme gene is on chromosome 5, which means you also get it from both parents.

After testosterone is converted to DHT, binds to the receptor, and is internalized into a cell to move on into the nucleus, the result is pretty much based upon your immune response and your body's ability to handle the downstream chemical mediators that seem to cause perifollicular fibrosis, collagen deposition, and in some people possible venous stasis or lymphedema.

Huh ?? !!

 

[docj077]

So male hairloss is passed on through females ? ! Why and WTF ? !

Why does evolution hate head hair so much anyway ? !

Surely it is body hair that is not required anymore and should be slowly breeding out .....

God damn DNA !!

The androgen receptor is on the X chromosome that you get from your mom. The 5alpha reductase type II enzyme gene is on chromosome 2, so you get that from both parents.
After testosterone is converted to DHT, binds to the receptor, and is internalized into a cell to move on into the nucleus, the result is pretty much based upon your immune response and your body's ability to handle the downstream chemical mediators that seem to cause perifollicular fibrosis, collagen deposition, and in some people possible venous stasis or lymphedema.

Doctor are you sure the DHT receptor is only the X chromosome? Also can you explain what you mean by perifollicular fibrosis, collagen deposition, and lymphedema and how exactly this miniturizes hair.

PS The androgen receptor is in the cell and not on the surface so the DHT diffuses in. Then I'm guessing the complex leads to fibrosis etc...?

The androgen receptor gene is on only the X chromosome. I have not seen a study that says otherwise. Everytime I read a study involving triplet repeat mutations in the androgen receptor, it's always localized to the X chromosome.

As you said, the androgen receptor is cytoplasmic as it is indeed a nuclear receptor protein. DHT is lipid soluble, so it moves across, binds the receptor, induces a conformational change, and the whole complex becomes a transcription factor. In the scalp, it appears that in vitro studies seem to show that the target is the TGF-beta gene. In the prostate, one of the targets is the prostate specific antigen promoter.

Lastly, when I say perifollicular fibrosis and collagen deposition, that's actually what is observed at the microscopic level when a lab tech. or pathologist examines someone with androgenic alopecia. I've had this pathology confirmed with a dermatopathologist. In some cases, the histology can demonstrate an inflammatory response with increased immune cell infiltrates. Once this process occurs, the nutritional framework of the follicle is compromised and the area surrounding the follicle is filled with fibrosis and incredible amounts of collagen.

Foote's theory says that androgen binding on striated muscle and the corresponding hypertrophy causes venous stasis and lymphedema. I don't buy it, because the lymphatics run too close to the skin and even muscle hypertrophy would not cause lymphedema. He also states that androgens may bind to the valves and endothelial cells within lymphatics. Again, something I don't think happens as androgen receptor carcinomas from the prostate will stain positive, but the surrounding lymph node and lymphatics will not when being investigated for prostate cancer metastasis.

Personally, I think the fibrosis and collagen deposition narrow blood flow to and from the dermal papilla of the hair follicle basically cutting off all nutrition. Not only that, but TGF-beta is a paracrine factor that can induce cell death in cells within the hair apparatus, so hair growth slows and finally remains at a very low level which is recognized as miniturization.

 

[hairhaircomeagain]

same here..and my brother keeps makin fun of me

 

[bubka]

So male hairloss is passed on through females ? ! Why and WTF ? !

Why does evolution hate head hair so much anyway ? !

Surely it is body hair that is not required anymore and should be slowly breeding out .....

God damn DNA !!

i dont think you understand how evolution and natural selection works... but anyways, you are surely not the same genetically as your brother

 

[Perfectionist]

Dude !!

I don't think you understand sarcasm or irony !!

 

[perceptions]

So male hairloss is passed on through females ? ! Why and WTF ? !

Why does evolution hate head hair so much anyway ? !

Surely it is body hair that is not required anymore and should be slowly breeding out .....

God damn DNA !!

The androgen receptor is on the X chromosome that you get from your mom. The 5alpha reductase type II enzyme gene is on chromosome 2, so you get that from both parents.
After testosterone is converted to DHT, binds to the receptor, and is internalized into a cell to move on into the nucleus, the result is pretty much based upon your immune response and your body's ability to handle the downstream chemical mediators that seem to cause perifollicular fibrosis, collagen deposition, and in some people possible venous stasis or lymphedema.

Doctor are you sure the DHT receptor is only the X chromosome? Also can you explain what you mean by perifollicular fibrosis, collagen deposition, and lymphedema and how exactly this miniturizes hair.

PS The androgen receptor is in the cell and not on the surface so the DHT diffuses in. Then I'm guessing the complex leads to fibrosis etc...?

The androgen receptor gene is on only the X chromosome. I have not seen a study that says otherwise. Everytime I read a study involving triplet repeat mutations in the androgen receptor, it's always localized to the X chromosome.

As you said, the androgen receptor is cytoplasmic as it is indeed a nuclear receptor protein. DHT is lipid soluble, so it moves across, binds the receptor, induces a conformational change, and the whole complex becomes a transcription factor. In the scalp, it appears that in vitro studies seem to show that the target is the TGF-beta gene. In the prostate, one of the targets is the prostate specific antigen promoter.

Lastly, when I say perifollicular fibrosis and collagen deposition, that's actually what is observed at the microscopic level when a lab tech. or pathologist examines someone with androgenic alopecia. I've had this pathology confirmed with a dermatopathologist. In some cases, the histology can demonstrate an inflammatory response with increased immune cell infiltrates. Once this process occurs, the nutritional framework of the follicle is compromised and the area surrounding the follicle is filled with fibrosis and incredible amounts of collagen.

Foote's theory says that androgen binding on striated muscle and the corresponding hypertrophy causes venous stasis and lymphedema. I don't buy it, because the lymphatics run too close to the skin and even muscle hypertrophy would not cause lymphedema. He also states that androgens may bind to the valves and endothelial cells within lymphatics. Again, something I don't think happens as androgen receptor carcinomas from the prostate will stain positive, but the surrounding lymph node and lymphatics will not when being investigated for prostate cancer metastasis.

Personally, I think the fibrosis and collagen deposition narrow blood flow to and from the dermal papilla of the hair follicle basically cutting off all nutrition. Not only that, but TGF-beta is a paracrine factor that can induce cell death in cells within the hair apparatus, so hair growth slows and finally remains at a very low level which is recognized as miniturization.

Are you an Actual Doctor DocJ077 ? how old are you annd whats your educational back ground and norwood level ? How long have you been loosing ? is that green tea you are using topical or oral ?