Increasing finasteride dosage- any success case here??!!

[Balding78]

Yoz all,

Propecia works wonder for me for many years and as expected, the gene finally caught up and im started to recede on the hairline pretty aggressively past 2 years. I have seen on a few occasions recommendation of increasing finasteride dosage from propecia-1mg to half proscar 2.5mg or even a whole proscar 5mg.

However, from here I do read that finasteride is not dosage dependent and increasing it wouldnt really be helpful against the onset of aggressive male pattern baldness.

So it would really be good if any of ya out there have any success case through increasing the dosage when propecia isnt working as good before!

Tx a million!

 

[FreeloaderUK]

if propecia is losing effectiveness I doubt increasing the dosage will compensate Im afraid.

 

[medmax84]

There is an increase but it is not large. With the jump from 1 mg to 5 mg you will probably get a modest increase of 5AR inhibition and subsequent lowering of DHT. This is going to be a stopgap though, as the decrease would only be 10% or less and your hairloss will catch up again (if its even halted at all).

Perhaps Bryan can comment on whether all doses reach the same "steady-state" of DHT inhibition over time. I think he mentioned that over a course of time 0.25 mg ends up having the same basic inhibition of 5AR as 1 mg. If that is true, then increasing your dose is unlikely to have a significant effect.

It's speculation at best... and remember, at the 5 mg dose you are more likely to get sides.

Here is some data on a single dose of finasteride...whether this applies to long-term dosage, I am unsure.

 

[eXVee]

5mg of fina inhibits more dht during the first doses, but when taken continously, 1mg catches up with 5mg rather quickly and inhibits the same ammount.

 

[BLynch]

I think you are reading the chart wrong. The dth blocking is a result of 7 days after one single dose of propecia/proscar, not continual usage.

 

[medmax84]

5mg of fina inhibits more dht during the first doses, but when taken continously, 1mg catches up with 5mg rather quickly and inhibits the same ammount.

Oversimplification... and speculation at best. Ever seen Jerry Maguire?

SHOW ME THE STUDIES!

 

[medmax84]

I think you are reading the chart wrong. The dth blocking is a result of 7 days after one single dose of propecia/proscar, not continual usage.

Are you blind, stupid, illiterate, lazy or all of the above?

I pointed that out.

I will copy and paste it here for you:

Perhaps Bryan can comment on whether all doses reach the same "steady-state" of DHT inhibition over time. I think he mentioned that over a course of time 0.25 mg ends up having the same basic inhibition of 5AR as 1 mg. If that is true, then increasing your dose is unlikely to have a significant effect.

It's speculation at best... and remember, at the 5 mg dose you are more likely to get sides.

Here is some data on a single dose of finasteride...whether this applies to long-term dosage, I am unsure.

 

[Bryan]

5mg of fina inhibits more dht during the first doses, but when taken continously, 1mg catches up with 5mg rather quickly and inhibits the same ammount.

Oversimplification... and speculation at best. Ever seen Jerry Maguire?

SHOW ME THE STUDIES!

He's referring to the early finasteride study which included the graphs below. The only issue I have with what he said is that he should have said that it suppresses NEARLY the same amount of DHT, not "the same amount" (in a technical matter like this, we need to be as precise as possible, to avoid possible confusion).

It's graph A below which is what should be examined carefully (sorry that it's a little difficult to read). It shows that even when given in TINY doses for several days, finasteride has a cumulative effect, slowly suppressing more and more serum DHT, eventually getting down fairly close to what a full dose accomplishes (like 1 mg/day).

 

[medmax84]

5mg of fina inhibits more dht during the first doses, but when taken continously, 1mg catches up with 5mg rather quickly and inhibits the same ammount.

Oversimplification... and speculation at best. Ever seen Jerry Maguire?

SHOW ME THE STUDIES!

He's referring to the early finasteride study which included the graphs below. The only issue I have with what he said is that he should have said that it suppresses NEARLY the same amount of DHT, not "the same amount" (in a technical matter like this, we need to be as precise as possible, to avoid possible confusion).

It's graph A below which is what should be examined carefully (sorry that it's a little difficult to read). It shows that even when given in TINY doses for several days, finasteride has a cumulative effect, slowly suppressing more and more serum DHT, eventually getting down fairly close to what a full dose accomplishes (like 1 mg/day).

He was claiming that 0.25 mg inhibits the same amount of DHT in a cumulative manner as a 5 mg dose. I find that extremely hard to believe and I think he extrapolated your words to mean that dose is nearly irrelevant with finasteride.

 

[BLynch]

"5mg of fina inhibits more dht during the first doses, but when taken continously, 1mg catches up with 5mg rather quickly and inhibits the same ammount."

I was responding to this post you twat!

Second, you last post with the chart doesn't even show 5mg dose. So how does that answer the question of the original post. Increasing finasteride. dosage.

 

[medmax84]

"5mg of fina inhibits more dht during the first doses, but when taken continously, 1mg catches up with 5mg rather quickly and inhibits the same ammount."

I was responding to this post you twat!

Second, you last post with the chart doesn't even show 5mg dose. So how does that answer the question of the original post. Increasing finasteride. dosage.

Twat? You sound intelligent. I'm actually disappointed that I've dignified your idiocy with a response. Better luck next time.

 

[treadstone]

Man, what is wrong with some of you people.

 

[menace]

"5mg of fina inhibits more dht during the first doses, but when taken continously, 1mg catches up with 5mg rather quickly and inhibits the same ammount."

I was responding to this post you twat!

Second, you last post with the chart doesn't even show 5mg dose. So how does that answer the question of the original post. Increasing finasteride. dosage.

Twat? You sound intelligent. I'm actually disappointed that I've dignified your idiocy with a response. Better luck next time.

you need to relax and stop insulting others who are contributing.

 

[medmax84]

"5mg of fina inhibits more dht during the first doses, but when taken continously, 1mg catches up with 5mg rather quickly and inhibits the same ammount."

I was responding to this post you twat!

Second, you last post with the chart doesn't even show 5mg dose. So how does that answer the question of the original post. Increasing finasteride. dosage.

Twat? You sound intelligent. I'm actually disappointed that I've dignified your idiocy with a response. Better luck next time.

you need to relax and stop insulting others who are contributing.

I'm sorry your 18-post count gives you a lot of street cred I'm sure. Just kiddin :youbet:

If you'd read back through the thread, I was unjustly questioned first. If the overall consensus is that I'm not wanted here, I'll be more than happy to leave. However, if I spend a lot of time on my posts only to have people be lazy and not read them in their entirety, I'm going to get mad and I'm not going to be nice if they try to call me out on something that I've already made clear.

 

[$tackz]

I'm sorry your 18-post count gives you a lot of street cred I'm sure. Just kiddin :youbet:

If you'd read back through the thread, I was unjustly questioned first. If the overall consensus is that I'm not wanted here, I'll be more than happy to leave. However, if I spend a lot of time on my posts only to have people be lazy and not read them in their entirety, I'm going to get mad and I'm not going to be nice if they try to call me out on something that I've already made clear.

your better off becoming a writer for "baldingblog" :ididit:

 

[mastery]

After 2 good years on finasteride - I started to slide quickly back towards base line.

I increased the dose - starting with 1.5mg and over the course of about 4 months ending up on 5mg. I initially had good results everytime I upped the doseage but then it would fall away pretty quickly.

4 months ago I decided to jump onto dutasteride 0.5mg everyday. Yes I get some sides (brain fog, vivid dreams) but libido healthy as ever.

The hair is slightly thicker in appearance and recently shedding has slowed. However the hairline is struggling badly and getting worse. If I had stayed on finasteride it maybe better or worse - I am not sure ... but I think ultimately once finasteride loses its efficacy then we all have to turn to dutasteride ... until cloning comes along anyway...

 

[eXVee]

"5mg of fina inhibits more dht during the first doses, but when taken continously, 1mg catches up with 5mg rather quickly and inhibits the same ammount."

I was responding to this post you twat!

Second, you last post with the chart doesn't even show 5mg dose. So how does that answer the question of the original post. Increasing finasteride. dosage.

Well, I wasn't referring to the graph about a single dose. I was in a hurry, so I was hoping someone else would post the graph Bryan posted.

What does this graph has to do with the TS's question?

It shows us that:
1) Smaller doses of finasteride catch up with 1mg in a cumulative manner: 0.04mg after 14 days = (nearly) 1mg after 14 days
2) Larger doses catch up faster with 1 mg: 0.2mg after 3-4 days = 1mg after 3-4 days
3) The line showing 1 mg almost stagnates after 1 or 2 days showing us that maximum inhibition has been reached.

If we look at the first graph we see that a half of 1mg inhibits about 65% of a 5mg dose. If you know taking finasteride daily inhibits dht in a cumulative manner and that this effect is greater when the daily dose is larger. Do you really think that 1mg won't catch up with 5mg and inhibit the same amount rather quickly?