Curcumin is a known anti-fibrosis herb that is proven in its effectiveness both in vitro and in vivo. It's used to prevent digestive system cancers, melanoma, and even some cancers involving the immune system. One of its greatest achievements is its ability to prevent and even reverse fibrosis within kidneys that are undergoing an inflammatory process. It does this by inhibiting TGF-beta and I believe it can also inhibit TNF-alpha.
Green Tea extract is a TNF-alpha inhibitor, as well as, a very mild DHT synthesis blocker. I use it as a TNF-alpha inhibitor, but I mostly use it for the recent research that clearly demonstrates it lowers mortality secondary to cardiovascular events. Not only that, but it seems to make my face not seem so oily.
My hairloss plan is actually a little out of date. I haven't been using my finasteride for nearly three and half weeks now. I made that decision based upon some studies I read that showed the molecular problems that may occur with using 5alpha reducatase inhibitors. I also quit, because it was affecting my school work a lot.
Even though I've stopped by finasteride, my hair hasn't started shedding in giant piles everywhere. In fact, I don't think I've lost a single hair since I stopped. Stopping finasteride was only one part of hopefully showing that only inhibiting the downstream effectors like TGF-beta and TNF-alpha could possibly prevent hairloss.
It's actually been shown either in vitro or in vivo (sorry, but I can't remember) that finasteride actually decreases TGF-beta due to preventing the formation of DHT in the first place.
