Interview Of Professor Lowry William - Drug Uk5099 (study On Lactate Dehydrogenase Activity)

[H]

the equivalent of mice hair is human bodyhair. it grows with androgens, so i think that this study means nothing for our problem.
i recommend everyone to read this study :

Androgens and hair growth.
https://www.ncbi.nlm.nih.gov/pubmed/18844710

human head hair gets thinner with androgens, but other body and beard hair gets thicker !
that's why experiments on mice never work for human hair. it's like experimenting drugs on human beard ! but we know that what grows beards kills scalp hair.

the only mice that might be useful for Androgenetic Alopecia are these poor little creatures :
A mouse model of androgenetic alopecia.
https://www.ncbi.nlm.nih.gov/pubmed/20233794

Has anyone mapped molecular traffic in and out of body hair cells and compared them with scalp hair?

 

[Min0]

Has anyone mapped molecular traffic in and out of body hair cells and compared them with scalp hair?

no idea, but the first paper i linked should be read by everyone here, they link interesting studies as well.

[112]
Androgen-dependent beard dermal papilla cells secrete autocrine growth factor(s) in response to testosterone unlike scalp cells.
https://www.ncbi.nlm.nih.gov/pubmed/9804329
[114] Hibberts NA, Randall VA. Testosterone inhibits the capacity of cultured cells from human balding scalp dermal
papilla cells to produce keratinocyte mitogenic factors.
In: Van Neste DV, Randall VA, eds. Hair research for the
next millennium. Amsterdam: Elsevier, 1996: 303–306

[117] Obana N, Chang C, Uno H. Inhibition of hair growth by
testosterone in the presence of dermal papilla cells from
the frontal bald scalp of the post-pubertal stump-tailed
macaque. Endocrinol 1997: 138: 356–361


so, what makes animal bodyhair grow doesn't necessarily grow head hair for humans and some primates.
because our head hair is designed to be fucked by androgens at a certain age. yes even doner area and non balding people hair is getting nuked by androgens as we speak, but they either have less androgen receptors or less 5aR or have a mechanism that negates the effect of androgens.

if you take dermal papilla cells from the head of a non balding guy or a woman, and apply enough DHT, it will die.

THEY TYPE OF HAIR in question is the most important thing in hairloss research. for example if you want to study what estrogens effect on hair you must specify the type of hair you're talking about, because estrogens are good for head hair but are bad for body hair. the inverse is correct for androgens.

 

[Trichosan]

Has anyone mapped molecular traffic in and out of body hair cells and compared them with scalp hair?

It's possible as has been done in research on nitric oxide since 1997. Also possible to follow pathways in mitochondria, but I haven't seen many published studies on hair follicles. Much more could and should be done in this regard.

 

[H]

no idea, but the first paper i linked should be read by everyone here, they link interesting studies as well.

View attachment 63568

[112]
Androgen-dependent beard dermal papilla cells secrete autocrine growth factor(s) in response to testosterone unlike scalp cells.
https://www.ncbi.nlm.nih.gov/pubmed/9804329
[114] Hibberts NA, Randall VA. Testosterone inhibits the capacity of cultured cells from human balding scalp dermal
papilla cells to produce keratinocyte mitogenic factors.
In: Van Neste DV, Randall VA, eds. Hair research for the
next millennium. Amsterdam: Elsevier, 1996: 303–306

[117] Obana N, Chang C, Uno H. Inhibition of hair growth by
testosterone in the presence of dermal papilla cells from
the frontal bald scalp of the post-pubertal stump-tailed
macaque. Endocrinol 1997: 138: 356–361


so, what makes animal bodyhair grow doesn't necessarily grow head hair for humans and some primates.
because our head hair is designed to be fucked by androgens at a certain age. yes even doner area and non balding people hair is getting nuked by androgens as we speak, but they either have less androgen receptors or less 5aR or have a mechanism that negates the effect of androgens.

if you take dermal papilla cells from the head of a non balding guy or a woman, and apply enough DHT, it will die.

THEY TYPE OF HAIR in question is the most important thing in hairloss research. for example if you want to study what estrogens effect on hair you must specify the type of hair you're talking about, because estrogens are good for head hair but are bad for body hair. the inverse is correct for androgens.

So the hair cells are killing themselves when exposed to dht basically is what they are implying? Do you have link to any estrogen studies also?

 

[Min0]

So the hair cells are killing themselves when exposed to dht basically is what they are implying? Do you have link to any estrogen studies also?

Not killing themselvs, the androgens are killing it, by not promoting the expression of genes that code for growth.
how exactly estrogen effects hair is still poorly understood as far as i know. but they say that it is only good for head hair because estrogen counters the androgen effects. and not by directly promoting the expression of growth genes after it attaches to the Estrogen receptors.
it also reduced body hair, that's why women have no thick body hair.

 

[tylerduren]

Set a rat on fire and it will grow hair

 

[Noisette]

Thanks to those in the thread for their insights.

I really appreciate this debate on the topic.

I am sorry to answer now, I was busy. I read all your comments and questions, and tomorrow I will contact Professor Lowry William

Thank you again

 

[H]

Not killing themselvs, the androgens are killing it, by not promoting the expression of genes that code for growth.
how exactly estrogen effects hair is still poorly understood as far as i know. but they say that it is only good for head hair because estrogen counters the androgen effects. and not by directly promoting the expression of growth genes after it attaches to the Estrogen receptors.
it also reduced body hair, that's why women have no thick body hair.

I knew for some time androgens have the opposite effect on facial and body hair but now Im curious as to why there is an actual difference in scalp hair. Its finer and more abundant when you don't have hair loss but why the differentiation just on the scalp?

 

[Min0]

I knew for some time androgens have the opposite effect on facial and body hair but now Im curious as to why there is an actual difference in scalp hair. Its finer and more abundant when you don't have hair loss but why the differentiation just on the scalp?

the trillion dollar question.

 

[abcdefg]

the trillion dollar question.

Its kind of funny how head hair comes out easily just brushing it often not coming back if its male pattern baldness, while body hair is rooted in there so strongly you can rip it out by the root, and it always grows back.
That is why I have trouble with the idea that people can itch their head too hard or wear tight hair styles, and go bald from it. Have you seen how strong body hair is? Nothing can stop that stuff from growing nothing
A person without male pattern baldness seems like their hair would mimic body hair. Strongly rooted, and nothing you could do short of losing a patch of scalp could remove the hair follicles

 

[Min0]

Its kind of funny how head hair comes out easily just brushing it often not coming back if its male pattern baldness, while body hair is rooted in there so strongly you can rip it out by the root, and it always grows back.
That is why I have trouble with the idea that people can itch their head too hard or wear tight hair styles, and go bald from it. Have you seen how strong body hair is? Nothing can stop that stuff from growing nothing
A person without male pattern baldness seems like their hair would mimic body hair. Strongly rooted, and nothing you could do short of losing a patch of scalp could remove the hair follicles

all humans head hair thins with DHT, it's just a matter of when and the quantity of local formed DHT.
we always hear about steroid abusers losing their hair. you can't say all of them were gonna be bald anyway.
if you take hair even from women and nuke it with DHT it will fall.

non balding people either have low 5Ar or less androgen receptors on the hair or have a functional pathway that signals the follicles to grow again after getting hit by DHT.

 

[NewUser]

So DHT slowly destroys about 4% of the total bodily HF in about 33% of males, but it's necessary to stimulate hair growth everywhere else. It's the faulty hair follicle theory that has lead us almost nowhere.

 

[rupture]

Not killing themselvs, the androgens are killing it, by not promoting the expression of genes that code for growth.
how exactly estrogen effects hair is still poorly understood as far as i know. but they say that it is only good for head hair because estrogen counters the androgen effects. and not by directly promoting the expression of growth genes after it attaches to the Estrogen receptors.
it also reduced body hair, that's why women have no thick body hair.

I thought Estro was a WNT signaler

 

[rupture]

all humans head hair thins with DHT, it's just a matter of when and the quantity of local formed DHT.
we always hear about steroid abusers losing their hair. you can't say all of them were gonna be bald anyway.
if you take hair even from women and nuke it with DHT it will fall.

non balding people either have low 5Ar or less androgen receptors on the hair or have a functional pathway that signals the follicles to grow again after getting hit by DHT.

But than you see people like Arnold who used alot of Dbol and did not lose a hair. than long after his usage he began balding so something not DHT related is going on here at least in some people it seems

 

[Min0]

But than you see people like Arnold who used alot of Dbol and did not lose a hair. than long after his usage he began balding so something not DHT related is going on here at least in some people it seems

ofcourse there are different kinds of steroids that doesn't work like DHT.
but we know that in vitro, human hair cells die with DHT, even if it came from a woman hair model.

and we know that beard hair thrives with DHT.

 

[Min0]

I thought Estro was a WNT signaler

i don't know in the study they even said that estrogen connecting to the ER is bad for hair, and that it's only good for head hair because of its androgen negating activity. and they said that the relation of estrogen with head hair is under research.

 

[H]

So DHT slowly destroys about 4% of the total bodily HF in about 33% of males, but it's necessary to stimulate hair growth everywhere else. It's the faulty hair follicle theory that has lead us almost nowhere.

it makes sense you grow a beard after puberty not before.