Is it even possible to not inherit the male pattern baldness gene?

Autumn Sundown

Established Member
Reaction score
1
Every time I see someone with a balding dad, grandfather or mom they always seem to take after them. Is it possible to have someone in your close family who went bald young and not inherit their genes? The only cases I can think of are a few I read about online.
Do you know anyone who kept thick hair despite having bald/balding relatives?
 
M

macimate

Guest
The Hoff is still looking great, looks like he took after his mom..
 

s.a.f

Senior Member
Reaction score
67
Of course its possible same with inheriting any genetic trait.
 

optimystic

Member
Reaction score
0
its possible but we still dont know how probable it is

even if they identified which chromosomes the genes responsible for hairloss are, they have not yet identified all the gens responsible and even when they do they have to run numerous studies to find out how they are linked.

Hairloss is definitely a polygenic phenotype meaning it requires several versions (or specific alleles) of several genes to determine one phenotype. Such phenotypes accquired through polygenic inheritence can't be deciphered from the genome easily. Even if to us it would seem as easy as hairloss or no hairloss, there are so many genes at play that decide either of these phenotypes.
Depending on which genes are variable between a couple (which we dont know) and how these genes interact with one another in terms of dominance (which we also dont know) in some couple associations it might be so that even if both parents have hairloss, it might be so that none of the children experience hairloss if each parent happens to mask the defective allele in the other parent.

In other words, you cant predict or determine anything about hairloss inheritance all we do know is that its inheritable but its mode of inheritance has not been determined (atleast not completely)

As a holder of bachelor of science in biology i can tell you we have the technology and the know-how to determine such information (and the sooner its determined the sooner we can have better treatment and preventive options for hairloss)
But this requires alot of lab work (and many lab workers) and alot of accuracy and many samples of males with male pattern baldness, and also alot of expensive equipment and software to go with it. In other words, it requires alot of money, apparently too much for cosmetic companies to invest in.
Its alot cheaper to find a general underlying mechanism from some samples at a microscopic level than it is to find the full detailed mechanism and learn the genetics behind it.
Also if they discover the full genetic mechanism and find that its treatable through gene therapy or a specific drug(targeting the gene) that doesnt need to be administered regularly and can be a one time fix this will be less profitable for many companies (especially cosmetic companies since they have no means\role in selling this type of therapy)
 

VoteForPedro

Member
Reaction score
1
but you're basically just inheriting SENSITIVITY to DHT, or so they say...so if you're very sensitive to it, like i think i am...GOOD LUCK getting anything done about it. but sure, it's possible, like S.A.F. said...
optimystic said:
its possible but we still dont know how probable it is

s.a.f said:
Of course its possible same with inheriting any genetic trait.
 

VoteForPedro

Member
Reaction score
1
but you're basically just inheriting SENSITIVITY to DHT, or so they say...so if you're very sensitive to it, like i think i am...GOOD LUCK getting anything done about it. but sure, it's possible, like S.A.F. said...
s.a.f said:
Of course its possible same with inheriting any genetic trait.
 
Top