Is it possible the whole thing is caused by free testosterone being at an incorrect level?

[Hoppi]

Most receptors in the body are sensitised/upregulated as far as I know by simply getting too much or too little of the hormone they react to.

With age, testosterone production drops. Also, SHBG production increases, which binds free testosterone and makes it inactive.

Therefore we end up with less total T and far less free T.

So... the androgen receptors in our scalps (among other places) are not getting as much free T as they expect to get (typically the amount they would get when we are say 20). Therefore they become more sensitive. Which impacts the hair follicles, as we are familiar with.

And that's my theory, lol

I'm not sure why SHBG increases with age. Maybe it's in response to increasing estrogen or something, as I know that can increase with age (a weak liver can apparently cause it, for example).

Perhaps if one can increase their free T to the level expected by the receptors, yes at first you'd lose more hair but then they might calm down and you might stop losing hair completely, regrow, etc.

Interested to hear your thoughts!

 

[jamesbooker1975]

Most receptors in the body are sensitised/upregulated as far as I know by simply getting too much or too little of the hormone they react to.

With age, testosterone production drops. Also, SHBG production increases, which binds free testosterone and makes it inactive.

Therefore we end up with less total T and far less free T.

So... the androgen receptors in our scalps (among other places) are not getting as much free T as they expect to get (typically the amount they would get when we are say 20). Therefore they become more sensitive. Which impacts the hair follicles, as we are familiar with.

And that's my theory, lol

I'm not sure why SHBG increases with age. Maybe it's in response to increasing estrogen or something, as I know that can increase with age (a weak liver can apparently cause it, for example).

Perhaps if one can increase their free T to the level expected by the receptors, yes at first you'd lose more hair but then they might calm down and you might stop losing hair completely, regrow, etc.

Interested to hear your thoughts!

No, actually No . With Age, Progesterone Decrease. Progesterone is the natural 5-alpha-reductase plus aromatese inhibitor . Meaning, with age , your Free T go lower , but your DHT and your Estrogens increase . that is why the man boobs as we age, more belly fat, etc .

 

[DoctorHouse]

No, actually No . With Age, Progesterone Decrease. Progesterone is the natural 5-alpha-reductase plus aromatese inhibitor . Meaning, with age , your Free T go lower , but your DHT and your Estrogens increase . that is why the man boobs as we age, more belly fat, etc .

And your sensitivity to DHT increases too if your genetics program your DNA to do it. The rate will vary according to your genetics. Only treatments like finasteride with minoxidil might slow it down to a snail's pace if you are lucky. As the follicles keep getting bombarded with DHT as they age, it's basically like chipping away at a tree until it comes tumbling down.

 

[Hoppi]

No, actually No . With Age, Progesterone Decrease. Progesterone is the natural 5-alpha-reductase plus aromatese inhibitor . Meaning, with age , your Free T go lower , but your DHT and your Estrogens increase . that is why the man boobs as we age, more belly fat, etc .

So you're saying that you believe it's a lack of progesterone that makes the androgen receptors upregulate, not a lack of free T?

And your sensitivity to DHT increases too if your genetics program your DNA to do it. The rate will vary according to your genetics. Only treatments like finasteride with minoxidil might slow it down to a snail's pace if you are lucky. As the follicles keep getting bombarded with DHT as they age, it's basically like chipping away at a tree until it comes tumbling down.

And you're saying it's simply genetics as opposed to free T?

 

[Hoppi]

I did find this on Wikipedia:

"The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor."

It seems to be the only other thing that can interact with it really, other than androgens.

Finasteride blocks androgen receptors too though. And if you block them they just get more sensitive, if anything.

Even free DHT decreases with age so these poor receptors as we age will be getting a fraction of the activation they were when we were younger. No wonder they get muddled up!

 

[jamesbooker1975]

I did find this on Wikipedia:

"The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor."

It seems to be the only other thing that can interact with it really, other than androgens.

Finasteride blocks androgen receptors too though. And if you block them they just get more sensitive, if anything.

Even free DHT decreases with age so these poor receptors as we age will be getting a fraction of the activation they were when we were younger. No wonder they get muddled up!

That don't explain why people can started male pattern baldness as soon as 14th .

 

[Hoppi]

That don't explain why people can started male pattern baldness as soon as 14th .

It would depend what the receptors are "set" to wouldn't it really. That part probably is genetic.

 

[losingbattle88]

I used to take 20mg natural progesterone on my balls and after a year my hair had gotten way thinner wouldnt recommend.

 

[Hoppi]

I used to take 20mg natural progesterone on my balls and after a year my hair had gotten way thinner wouldnt recommend.

Yeah the progesterone approach doesn't really make sense to me because if it's just an androgen receptor blocker then... we already have lots of those, lol

I'm not sure if there would be a benefit to using it topically on the scalp though.

... I won't ask why you were putting it on your balls o.0

 

[losingbattle88]

Yeah the progesterone approach doesn't really make sense to me because if it's just an androgen receptor blocker then... we already have lots of those, lol

I'm not sure if there would be a benefit to using it topically on the scalp though.

... I won't ask why you were putting it on your balls o.0

Used to use it on armpits but its better on balls

 

[jamesbooker1975]

I used to take 20mg natural progesterone on my balls and after a year my hair had gotten way thinner wouldnt recommend.

Do I really need to tell you that you MUST do a bloodwork to know where progesterone is before you do use it ? Besides , 20mg is a lot for a mail .

 

[losingbattle88]

Do I really need to tell you that you MUST do a bloodwork to know where progesterone is before you do use it ? Besides , 20mg is a lot for a mail .

I just wanted to block dht thats all. I heard it can lower dht. Me and a guy tried it out it worked for him better than me.

 

[Ideaforgrowth]

Howdy, new here. Long story short to say why about to say here but ... I think its a lack of 5 Ar. Get ahold of some Synthetic 5Ar or find a natural way to flood our body with that and that very well is our answer/solution. Around 2014 a university in Texas created some with that Dr Christina or whatever here name was.

 

[DoctorHouse]

So you're saying that you believe it's a lack of progesterone that makes the androgen receptors upregulate, not a lack of free T?



And you're saying it's simply genetics as opposed to free T?

Genetics is only part of the puzzle. It can dictate how your hair follicles react to DHT. But I do believe you can alter your genetics by environmental factors.

 

[Hoppi]

Howdy, new here. Long story short to say why about to say here but ... I think its a lack of 5 Ar. Get ahold of some Synthetic 5Ar or find a natural way to flood our body with that and that very well is our answer/solution. Around 2014 a university in Texas created some with that Dr Christina or whatever here name was.

You think that a lack of 5ar in the bloodstream upregulates the receptors?

Two thoughts on that:

a) is it even in the bloodstream? lol. I honestly don't know.

b) I'm not sure if androgen receptors can even detect that.

Genetics is only part of the puzzle. It can dictate how your hair follicles react to DHT. But I do believe you can alter your genetics by environmental factors.

I mean, I would agree that some people are not susceptible to male pattern baldness genetically. But we are so we have to work within that! heh

As for changing one's genetics... I have no idea about that!

 

[Ideaforgrowth]

Howdy. Well, I honestly do not know 100 percent but like I said too much to write here to explain how I was given this information. It partially has to do with body hair and when it's triggered to grow on us or anything 5ar is used for . Those new 5ar needs steal (something ) from the scalp because the lack of 5ar to support everything. Like you mention though I imagine probably factors like receptor sensitivity is in play too. It was found there was not enough 5 ar to support scalp functions when body hair starts to be triggered to grow. I think when we take a " dht blocker " it's really juggling where the 5ar goes . Im interested to hear anyone's thoughts. Oh one more thought. So that's why when we take the dht blockers body hair retreats/ miniaturizes because the 5 ar has been blocked at those receptors and makes it back up to the scalp. Additionally, if a man has more than enough of this 5ar, he can have super thick body, beard and scalp hair.

 

[jimtmcdaniels]

Does anyone see a parallel with hair loss being right above our brain, the hair loss pattern almost looking like a diagram of brain over activity areas?
You know, coming of age, when we often over think and many experience mental health issues and substance abused to try to cope..

 

[Derek Clapton]

Does anyone see a parallel with hair loss being right above our brain, the hair loss pattern almost looking like a diagram of brain over activity areas?
You know, coming of age, when we often over think and many experience mental health issues and substance abused to try to cope..

Not the brain but I do have a complete bro science theory that it's along the lines of a piece of pizza dough thrown onto the head of a mannequin - gravity will stretch the central areas most. That would translate to less blood flow etc. I think there's something in those devices you can wear that lift the scalp skin and allow blood to flow better there.