Gadgetine

Is Nizoral 2% daily safe? Cassin?

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CCS

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I read cassin's regimen. I think he uses it, or did.

Yeah, it says you are supposed to stop using it every 4 weeks, and says only to use it twice a week. Yet they did studies on guys with 2% topical twice a day for 6 months. Granted, these were not safety studies, just 6 man study to see if it works. Somehow I doubt I would need a break. Just wondering what other people say though.

I used Nizoral 1% every day for 6 months and had not trouble. My hair was a bit dry though.
 
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CCS

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He no longer shows his regimen. Fact is he probably does not know anyway. So may new question is, who here uses 2% Nizoral and how often?
 
C

CCS

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Cassin said:
I don't see how that could possibly do anything but damage.

Nizoral dries out the scalp and hair follicle.

More is not better.
Click to expand...

What is your oppinion of the guys using daily keto cream? Or are they using it daily?
 
Grantspots

Grantspots

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Why do people use 2% in the first place?

Isn't 1% sufficient for most guys? Except those with extreme scalp issues?

Or is it all just part of the OCD mentality most of us on this site have, to go for the big guns right away no matter what?

-G-
 
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CCS

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They did a 6 month study that showed 1% and 2% to be just as good. But maybe, just maybe, 6 months was not enough time to see a difference. Maybe a year or more would have shown 2% better, at least for maintanence. I mean, there was a 6 man study with 2% keto cream, and they had some phenominal results. The 3 older guys were mildly better, but the 3 younger guys were way better than minoxidil results. And keto is also an anti-androgen, so that means maintenance.


Cream is too expensive though. $15 for 15 grams of 2% cream. Or maybe it was 30 grams. Either way, I can get 200mL of 2% keto for $17. It has detergent unfortunately, but at least it lathers and goes everywhere.

So I'm thinking I'll give the 2% a go. Just not sure how often I'll use it. I want the multi-angled approach of alternating it with piroctone olamine. But I still have some lavender and apple poly I'd like to add somehow. Not sure if I should drop the spironolactone shampoo or not, since spironolactone only lasts 10 hours in the scalp. I got a good supply too.
 
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kento

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CCS said:
He no longer shows his regimen. Fact is he probably does not know anyway. So may new question is, who here uses 2% Nizoral and how often?
Click to expand...

There where two stories with photos in the "Success Story" section, plus not to forget the study with the cream. I've started to use nizoral 2% 2-3 week and my scalp never feel better in my live. After the weather got hotter i plan to use it every other day + conditioner.
 
patagonia

patagonia

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I use keto shampoo 2% every 3rd day. I mix it in a little plastic cup with Nano shampoo and regular curcumin before applying. Feels great. I leave it on my scalp at least 10 minutes before rinsing.

On the other days I use PO shampoo which has Finas.... about .05% and Tea tree oil, cedarwood, rosemary oils all previously added to that PO shampoo. I make a 40 ml batch of this shampoo mix at a time, and keep it in the fridge. Combine this one with Nano shampoo and curcumin in a cup before shower as well. leave it on for 10 -15 min.

been using this for a year and hair has thickened up....so far so good.

( I added finas in shampoo about 4 months ago)

I believe shampoos are a great way to apply added ingredients in what seems to be an optimal time for absorbtion in a good delivery vehicle
 
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SoThatsLife

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CCS, you could try the keto foam if it is cheaper than the cream, its called extina.

There is one study that compares foam vs cream, but its not hair loss related directly. I think they use the same carrier in Extina foam and Rogain foam.

Ketoconazole 2% Foam as Effective as Ketoconazole 2% Cream for Seborrhoeic Dermatitis: Presented at AAD

By Bruce Sylvester

WASHINGTON, DC -- February 13, 2004 -- The investigative foam formulation of ketoconazole 2% is as effective for seborrhoeic dermatitis as ketoconazole 2% cream, researchers reported on February 9th here at the American Academy of Dermatology 62nd Annual Meeting.

"The efficacy data from this study demonstrate that ketoconazole foam is non-inferior (similar or better than) to ketoconazole cream," the investigators noted. "The data also demonstrate that ketoconazole foam was safe and well tolerated," they added.

The researchers enrolled 619 subjects (12 years or older and diagnosed with seborrhoeic dermatitis) in this 4-week multicentre, randomised, double-blind, double-dummy, placebo-controlled study.

The subjects were randomised to 1 of 4 study cohorts: active foam (n = 233), active cream (n = 233) or their vehicles (foam, n = 77 and cream, n = 76). Subjects self-administered twice each day.

The primary endpoint was the proportion of subjects with an Investigator's Static Global Assessment (ISGA) score of 0-1 at endpoint, defined as "treatment success."

The secondary endpoint was percent change from baseline to 4 weeks in sum of scores of the signs of seborrhoeic dermatitis (erythaema, scaling and induration) at target area.

The investigators also noted the proportion of subjects achieving a 0 ISGA, or "clear," for all groups.

The difference in "treatment success" rate between foam and cream was 5.58%. There was a "trend in favor of ketoconazole foam versus foam vehicle," the investigators reported. "Treatment success was achieved by 50% of patients treated with ketoconazole foam, and 44% of patients treated with ketoconazole cream," they said.

For improvement in sum of scores from baseline to endpoint (intent-to-treat population), the difference between ketoconazole foam and cream formulations was 4.48 %. "The median percent change from baseline in the sum of scores of signs of seborrhoeic dermatitis at the target area was 80% for ketoconazole foam and 67% for ketoconazole cream," the investigators noted.

For a "clear" score of 0 on ISGA at Week 4 (intent-to-treat population), the reported difference between ketoconazole foam and ketoconazole cream formulations was 6.44%.
"Additionally, an ISGA score of 'clear' was achieved by 39% of patients treated with ketoconazole foam, and 33% of patients treated with ketoconazole cream," the authors wrote.

The researchers added that the most frequent adverse ketoconazole-foam reactions were mild and transient application-site reactions, resulting in no early subject withdrawals from the study.


[A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled Study of the Safety and Efficacy of Ketoconazole Foam, 2%, Versus Ketoconazole 2% Cream in the Treatment of Seborrheic Dermatitis. Abstract 397]
 
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CCS

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That thread says it is safe to use.

I think the super effects of the cream are not anti-androgenicly based. I think they are stimulant based. You up the dose of a stimulant, you get more regrowth. You up the dose of an anti-androgen, you get better maintainance. But either way, sounds like 2% would be a winner.
 
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SoThatsLife

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CCS, I guess you could think of keto as something that are working against the male pattern baldness's immune response(inflammation). There have been some studies where they have used topical immune suppressants on balding scalp(i think it as cyclo), and many had good regrowth. Balding seems so complex, one could fight dht with an antiandrogen and get some growth, but then one could use a topical immune suppressant and get some growth. Proxiphen from Dr. Proctor has just a low dose of spironolactone as the only "real" antiandrogen and still it grows and strengthen hair by somewhat healing the follicle.

After watching a documentary about future medicine, where they said that it was the human immune system that stopped the cells to regenerate(and showed a impressive microscope film on a wound with and without immune system). I believe that the only thing that stops the Follica procedure from being the halfcure we are looking for, is the immune system. Follica know that they can't put people on internal immune suppressant for a week or two, so they have hired Samir Mitragotri to see if they can work out a way to apply a topical immune suppressant without damaging the follica procedure.

Edit: link to the study on Bryans page : http://www.geocities.com/bryan50001/cyclosporin.htm
 
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CCS

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SoThatsLife said:
CCS, I guess you could think of keto as something that are working against the male pattern baldness's immune response(inflammation). There have been some studies where they have used topical immune suppressants on balding scalp(i think it as cyclo), and many had good regrowth. Balding seems so complex, one could fight dht with an antiandrogen and get some growth, but then one could use a topical immune suppressant and get some growth. Proxiphen from Dr. Proctor has just a low dose of spironolactone as the only "real" antiandrogen and still it grows and strengthen hair by somewhat healing the follicle.

After watching a documentary about future medicine, where they said that it was the human immune system that stopped the cells to regenerate(and showed a impressive microscope film on a wound with and without immune system). I believe that the only thing that stops the Follica procedure from being the halfcure we are looking for, is the immune system. Follica know that they can't put people on internal immune suppressant for a week or two, so they have hired Samir Mitragotri to see if they can work out a way to apply a topical immune suppressant without damaging the follica procedure.

Edit: link to the study on Bryans page : http://www.geocities.com/bryan50001/cyclosporin.htm
Click to expand...

sounds good. Yeah, my vertex hairs and top middle used to hurt when I stroked them. Since using Nizoral, that feeling went away.
 
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