Is Pre-mixed Ru58841 From Anageninc G2g?

[CuckedByChad]

What is the general consensus here?

I've read multiple threads about it not being stable for long enough to keep working in pre-mixed solutions, yet AnagenInc claims their RU58841 is stable up to 6 months at room temperature. Which one is it?

Did I get scammed buying pre made solutions from them? I've been applying it for 2.5 weeks now and I do think my hair loss has gotten better (less hair falling out too). But the degradation of the compound over time has me worried. Is this no longer an issue with their ''new'' form of synthesis?

I'd prefer just buying the premixed ones since money isn't really an issue. The only thing that I was worried about is the degradation.

 

[Ollie]

I buy Kane's RU in powder form and still have no idea if its what its meant to be

 

[IdealForehead]

There is no published evidence suggesting RU is actually unstable in solution. I am not sure how this "rumor" began.

The best "evidence" comes from this site, which is a competitor of Kane's, and it suggests that since nilutamide is supposedly prone to hydrolysis (breakdown in the presence of water), and it is similar to RU58841 in structure, so too must be RU58841.

However, the claim RU58841.info makes is about nilutamide being prone to breakdown in water is an absolute lie.

I have reviewed the article they reference that they claim suggests this. The article actually makes no such claim.

To the contrary, here is what the article actually says, which is the same thing twice:

Abstract: Nilutamide showed significant degradation under basic hydrolysis and photolytic stress conditions, while it was stable to neutral, acidic and thermal stress conditions.

Discussion: The drug forms four degradation products, DP-I (retention time, Rt = 7.9 min), DP-II (Rt = 5.6 min), DP-III (Rt = 5.8 min) and DP-IV (Rt = 8.4) min under alkaline hydrolysis, and fifth, DP-V (Rt = 8.8 min), under photolytic conditions, while it was stable to neutral, acidic and thermal stress conditions.​

"Neutral" stress conditions meant exposing it to neutral pH water for 48 hours. Acidic conditions meant adding acid, alkaline conditions meant adding base. Photolytic stress was stress from strong light. Thermal stress was heating it.

Out of all that, only under alkaline conditions in the presence of water did nilutamide significantly break down. There was a mild degree of breakdown under photolytic stress. This is why Kane ships in dark bottles - to protect from light. But there was no breakdown under neutral water exposure, acidic water exposure, or heat stress conditions.

Solution stability tests are very hard to run as describe here so it is difficult to objectively confirm with RU58841. But I have seen zero evidence that it is actually unstable in solution.

In my opinion, this is therefore likely just an unfounded urban legend, and probably it is fine.

 

[CuckedByChad]

There is no published evidence suggesting RU is actually unstable in solution. I am not sure how this "rumor" began.

The best "evidence" comes from this site, which is a competitor of Kane's, and it suggests that since nilutamide is supposedly prone to hydrolysis (breakdown in the presence of water), and it is similar to RU58841 in structure, so too must be RU58841.

However, the claim RU58841.info makes is about nilutamide being prone to breakdown in water is an absolute lie.

I have reviewed the article they reference that they claim suggests this. The article actually makes no such claim.

To the contrary, here is what the article actually says, which is the same thing twice:

Abstract: Nilutamide showed significant degradation under basic hydrolysis and photolytic stress conditions, while it was stable to neutral, acidic and thermal stress conditions.

Discussion: The drug forms four degradation products, DP-I (retention time, Rt = 7.9 min), DP-II (Rt = 5.6 min), DP-III (Rt = 5.8 min) and DP-IV (Rt = 8.4) min under alkaline hydrolysis, and fifth, DP-V (Rt = 8.8 min), under photolytic conditions, while it was stable to neutral, acidic and thermal stress conditions.​

"Neutral" stress conditions meant exposing it to neutral pH water for 48 hours. Acidic conditions meant adding acid, alkaline conditions meant adding base. Photolytic stress was stress from strong light. Thermal stress was heating it.

Out of all that, only under alkaline conditions in the presence of water did nilutamide significantly break down. There was a mild degree of breakdown under photolytic stress. This is why Kane ships in dark bottles - to protect from light. But there was no breakdown under neutral water exposure, acidic water exposure, or heat stress conditions.

Solution stability tests are very hard to run as describe here so it is difficult to objectively confirm with RU58841. But I have seen zero evidence that it is actually unstable in solution.

In my opinion, this is therefore likely just an unfounded urban legend, and probably it is fine.

I love these well-written, scientifically backed posts, thanks a lot.

Looks like I'll continue using it and we'll see if it works or not.

 

[jonnywalker93]

I love these well-written, scientifically backed posts, thanks a lot.

Looks like I'll continue using it and we'll see if it works or not.

Hey man, how are you getting on with the premixed solution?

 

[bluecyclone]

Any luck with the RU?

 

[bluecyclone]

Don’t mean to hijack this thread but was looking for help with this prep option. I used this for a few months alone, results weren’t bad nothing epic. It was however sort of easy to travel with as it comes with disposal tips and sealed vials.

Kerastase Densifique Hair Density Quality & Fullness Activator Program, 30 Count https://www.amazon.com/dp/B01BVVBL6I?ref=yo_pop_ma_swf

I want to mix RU at 5% into each vial, 15 days at a time. Any idea what I would need in terms of measurement? Is this a usable vehicle for RU?