Is The Cure For This Disease Anywhere Close?

[NewUser]

Dang there's more hope than I thought, I feel like a lot of these are too late for me, any of them for guys who will be cue balls in a couple of years?

Unless you have scarring alopecia, there's hope for something better in the near term. In the long term, there is Tsuji who is working on a procedure to grow hair on even cueballs so to speak, meaning hopefully every kind of hair loss, from burn victims and cancer patients to people with rare types of scarring alopecia.

"The dogma was that you were born with the total number of hair follicles that you were ever going to have. Their loss was considered permanent. Now, we know it's not." - George Cotsarelis

 

[abcdefg]

Unless you have scarring alopecia, there's hope for something better in the near term. In the long term, there is Tsuji who is working on a procedure to grow hair on even cueballs so to speak.

Yes there is always this hope, but I think the timeline for accomplishing something like this is a lot longer than projected. It will happen eventually, but a lot of things will happen eventually

 

[Willy31]

Tsuji's Method the one listed under Kyocera Riken would be the one, they anticipate limited release by 2020 but that would be in japan and limited to like 10,000 people at first I believe. The other possible hopeful ones would be Shiseido's RCH-01 which I believe is limited as well and in Japan anticipated for sometime next year that one might not help for extensive loss but should protect from further loss. Last would be Follica Rain which could possibly help extensive loss although I don't believe for someone completely bald but who knows, there are other options as well like polarityte but no anticipated release date on that one yet.

Why Follica will can not help guys completely bald? I'm completely bald by DUPA pattern, and Follica is my only hope. But I have not hair (zero). It's a problem for Follica?

 

[BaldyBalderBald]

Why Follica will can not help guys completely bald? I'm completely bald by DUPA pattern, and Follica is my only hope. But I have not hair (zero). It's a problem for Follica?

I believe in Follica personally, but there are too many points that remain elusive today.

Density ? Thickness ? Hair direction ? We don't know anything about that actually, no results whatsoever.

All we know is that they can grow "new" follicles...If it is for 15-30 hair/cm² growing in all damn directions and thin as f***, this won't do the deal

Anyway, wound-induced hair follicle neogenesis works...now we got to know how good it works, hoping this congress will give some answers by next month...wait and see

 

[INT]

Everyone says cure without saying what that means. Cure like going from Norwood 4 back to Norwood 1? I think its many decades away bare minimum. Most likely male pattern baldness treatment progresses very slowly with a new mediocre treatment every decade or so, and you need a kitchen sink approach to get better results. So its going to be a very expensive condition to treat.
There will be no home run treatment. Just more propecia type treatments that help get a little hair back, but nothing major. Prevention will always be key for a long long time to come. AAs wont go anywhere just be complemented by new treatments from different angles.
A lot of people in these forums IMO are delusional about these grand slam future treatments that will cure male pattern baldness completely. Not very likely to happen anytime soon IMO given how complicated male pattern baldness is.

Agreed.

I do believe that somewhere in the next 5 years we will have something new on the market but this will max grow a Norwood or 1,5.

 

[H]

If Tsuji works and everything works like their site predicts case closed 2020.

 

[Bf20]

Master Tsuji i put my faith in you and you only.

 

[thomps1523]

Everyone says cure without saying what that means. Cure like going from Norwood 4 back to Norwood 1? I think its many decades away bare minimum. Most likely male pattern baldness treatment progresses very slowly with a new mediocre treatment every decade or so, and you need a kitchen sink approach to get better results. So its going to be a very expensive condition to treat.
There will be no home run treatment. Just more propecia type treatments that help get a little hair back, but nothing major. Prevention will always be key for a long long time to come. AAs wont go anywhere just be complemented by new treatments from different angles.
A lot of people in these forums IMO are delusional about these grand slam future treatments that will cure male pattern baldness completely. Not very likely to happen anytime soon IMO given how complicated male pattern baldness is.

Have you told dr Tsuji your thoughts? I mean he deserves to know he's just pissing in the wind. Let's be honest we all know your credentials trump that bird brained dope, amirite?

 

[Jonnyyy]

Theres people who are completely negative like that guy, and then there's those who are completely too optimistic I would say dr Tsujis plan will be available by 2022 and affordable around 2025 but even if I have to save 100,000 to get this done count me in, I'd look hideous bald.

 

[pollutionbrain]

Theres people who are completely negative like that guy, and then there's those who are completely too optimistic I would say dr Tsujis plan will be available by 2022 and affordable around 2025 but even if I have to save 100,000 to get this done count me in, I'd look hideous bald.

Why do u think the price will end up at 100k in 2025? Do u think it would be expensive to clone hair or simply that the demand would be great.

 

[NewUser]

Yes there is always this hope, but I think the timeline for accomplishing something like this is a lot longer than projected. It will happen eventually, but a lot of things will happen eventually

Yes who can predict the future? Not me, that's for sure. But there are a few people who have been able to predict certain technological milestones in the tech sector, like Ray Kurzweil. His predictions for that sector of the economy have been somewhat accurate. He's also predicted that most diseases will be solved by the 2030s which means they could happen in our life times! And there are statements from the medical research community supporting Kurzweil's enthusiasm for tech advances in medicine.

A legit baldness treatment in a few years? It's entirely realistic. Highly likely imho. Eventually the treatment of choice will be a cream or ointment, probably in a tube or jar. Imagine smarter drugs, or even tiny nanobots setting up shop in your scalp and going to work with skill saws, tool belts and hammers whipping up new hair follicles for us. Ok that sounds absurd, but the point is that baldness will become a matter of choice at some point.

 

[Jonnyyy]

Why do u think the price will end up at 100k in 2025? Do u think it would be expensive to clone hair or simply that the demand would be great.

I don't think the price will be quite up there but it will be expensive, the first people who will get it are probably actors and models who also have the exposure and the demand will become so much that sooner or later someone will find Tsujis way of cloning and will do the same thing in the US, but Riken will be smarter than that to let it happen, they'll open up their clinics after the FDA regulates them and slows them down a few years, if successful there's many billions of dollars in this treatment and they can price it pretty damn high and a lot of us will still buy it.

 

[NewUser]

They can't charge too much. The banks and government are already taking most of everyone's pay checks leaving not a lot for discretionary spending. They can make up for lower prices by selling more procedures or whatever the case is, in the shortest amount of time before any competition catches up to them.

Too, Japanese CEOs and firms are different than your typical Wall St or Bay St firms. Japan's companies have been willing to operate at lower profit margins than North American counterparts. They've even operated at cost to produce if it meant keeping the company alive and Japanese workers in jobs. Their business leaders are somewhat loyal to the national effort, whereas our guys are just dog eat dog in their business planning.

 

[cocona]

If by cure you mean reversing the actual causes of Androgenetic Alopecia then no.

Better treatments are on the horizon. The ability to get more and more hair back will continue to come. Things will only get better. Going from nw7-0 will become more feasible and easier and easier.

Treatments are not cures though. They attack the symptoms not the causes.

Saying we know we're going to have the disease conquered in the next 3 years is really an unjustified claim, we still do not even really understand hair loss.

 

[Jonnyyy]

If by cure you mean reversing the actual causes of Androgenetic Alopecia then no.

Better treatments are on the horizon. The ability to get more and more hair back will continue to come. Things will only get better. Going from nw7-0 will become more feasible and easier and easier.

Treatments are not cures though. They attack the symptoms not the causes.

Saying we know we're going to have the disease conquered in the next 3 years is really an unjustified claim, we still do not even really understand hair loss.

We understand hairloss for the most part, hell we can probably go from Norwood 7 to 0 we just don't know any treatments that will do that and won't give you side effects, if we had unlimited funding I think the cure for hairloss would be here in like 2 years, the amount of projects that don't go through testing because of money is ridiculous but then again we're the minority, who gives a f*** about us, wait until the selfie generation start going bald, funding will be out the roof, I know that because I'm party ofbthat generation and I wasn't really too into my looks but now it seems like that's all I care about.

 

[cocona]

We understand hairloss for the most part

This claim is false and egregiously ignorant.

Sorry

Even if Kythera's hypothesis is correct we still don't understand what causes DHT to increase PGD2 or why GPR44/CRTH2 seems to trigger an immune reaction attacking the follicle.

We have a lot more than we did in the past especially within the last 5 years but saying we actually understand hair loss is just an overwhelmingly arrogant and ignorant claim.

We are close to a greatly simplified model which explains it though. I guess I'll give you that.

 

[Jonnyyy]

This claim is false and egregiously ignorant.

Sorry

Even if Kythera's hypothesis is correct we still don't understand what causes DHT to increase PGD2 or why GPR44/CRTH2 seems to trigger an immune reaction attacking the follicle.

We have a lot more than we did in the past especially within the last 5 years but saying we actually understand hair loss is just an overwhelmingly arrogant and ignorant claim.

We are close to a greatly simplified model which explains it though. I guess I'll give you that.

I agree it's hard to explain but 20 years ago scientists didn't know sh*t about hairloss look now we have all kinds of things coming up, hard to believe there won't be a cure in another 20.

 

[NewUser]

I think cocona is right. If they understood pattern baldness enough to cure it, then we would have a cure, and there aren't many cures for diseases today. I could be wrong, but I think hair loss researchers could be taking a bit of a simplistic engineering approach to this vexingly difficult problem to solve. If hair loss could be reduced to a simpler analogy, say, a long electrical wire with a single LED light on the very end of it, and the light just isn't turning on. If hair loss is a bulb or LED not lighting up at the very end of a 200-foot wire wrapped around the house, then we go outside, with a flashlight, because it's 2 am and drank too much vino, and check the AC power outlet. It's plugged in but still no light. So we walk the first two feet of length and find a break in the wire. We splice it back together and wrap the connection in black tape. What do we do next? Should we walk the entire length looking for all possible breaks in the wire, and we know there are many things that are detrimental to hair growth. But no, the firs thing we do is plug the wire back into the AC outlet and test the whole wire again, because the single splice might possibly be the only break in the wire preventing the light from coming on. I think hair loss researchers are saying, Look, we know this is critical to hair growth, so let's first try blocking janus kinase, or PGD2 or whatever, and then test it to see if hair growth is switched on. If it works in vitro and in vivo with mice, then let's do clinical trials. There could be many cracks in the insulation of the wire and not an ideal situation for the physical wire, but let's gamble and see if making one splice in what could be the only thing stopping the LED from turning on, is all we need to do. It might be a waste of time finding every minor defect in the wire because the first one could be the only break that needs fixing. Similarly, it could be that there is one critical break in a cellular signaling pathway that turns on hair growth.

 

[Jonnyyy]

I think cocona is right. If they understood pattern baldness enough to cure it, then we would have a cure, and there aren't many cures for diseases today. I could be wrong, but I think hair loss researchers could be taking a bit of a simplistic engineering approach to this vexingly difficult problem to solve. If hair loss could be reduced to a simpler analogy, say, a long electrical wire with a single LED light on the very end of it, and the light just isn't turning on. If hair loss is a bulb or LED not lighting up at the very end of a 200-foot wire wrapped around the house, then we go outside, with a flashlight, because it's 2 am and drank too much vino, and check the AC power outlet. It's plugged in but still no light. So we walk the first two feet of length and find a break in the wire. We splice it back together and wrap the connection in black tape. What do we do next? Should we walk the entire length looking for all possible breaks in the wire, and we know there are many things that are detrimental to hair growth. But no, the firs thing we do is plug the wire back into the AC outlet and test the whole wire again, because the single splice might possibly be the only break in the wire preventing the light from coming on. I think hair loss researchers are saying, Look, we know this is critical to hair growth, so let's first try blocking janus kinase, or PGD2 or whatever, and then test it to see if hair growth is switched on. If it works in vitro and in vivo with mice, then let's do clinical trials. There could be many cracks in the insulation of the wire and not an ideal situation for the physical wire, but let's gamble and see if making one splice in what could be the only thing stopping the LED from turning on, is all we need to do. It might be a waste of time finding every minor defect in the wire because the first one could be the only break that needs fixing. Similarly, it could be that there is one critical break in a cellular signaling pathway that turns on hair growth.

Well said, I hope Dr Tsuji cures this and becomes the richest man alive. I'm not sure why there aren't enough people working on it, a cure for hairloss could literally lead to a company making extreme amounts of money, I guess it's the risk factors that nobody wants to take.

 

[NewUser]

Well said, I hope Dr Tsuji cures this and becomes the richest man alive. I'm not sure why there aren't enough people working on it, a cure for hairloss could literally lead to a company making extreme amounts of money, I guess it's the risk factors that nobody wants to take.

Exactly. Big pharmaceuticals have been notorious for picking the "low hanging fruit" in capitalizing on existing discoveries made by publicly funded research in academia and other institutes. Lots of examples, like the cancer drug Taxol among others. They love it when taxpayers foot the bills, and then they swoop in for the clinical trials at maybe phase 2 or 3 and especially if it looks promising. But big companies have run dry of blockbuster drugs with which their investors are paid big blue chip dividends. After riding the laurels of 20 and 30-year drug patent protections on old drug discoveries, the big companies are in need of new revenues, and big pharma is sitting on mountains of cash right now. And we are beginning to see some interest by smaller pharmas, like clinical stage specialists Aclaris, scooping up Angela Christiano's research, and Puretech taking Cotsarelis and his academic research and patents under their wing and continued research now has deep pockets to draw from. Tsuji-Riken-Meiji looks to be a very promising venture. Deep pockets are good for hair loss research. I think the CEOs of those companies are ready to take some risks in search of new blockbuster drugs and-or cell-based procedures for cosmetic applications like hair loss, skin rejuvination etc. There are a lot of people in the western world who just want to look and feel younger today and driving demand for anti-aging remedies. Hair loss is a big one for the baby boomers and millenials right now.