Is The Cure For This Disease Anywhere Close?

[NewUser]

This.

But don't get confused. We will have the cure in 10 to 20 years at best. He is right. To be cured means to have supress the desease and to get rid of it forever. It will only happens when scientists will discover how to get that sh*t done with genetics and understanding at 100% the big picture.
Even flu isn't cured,but you can get treated for it This is what will happens for hair loss : we will have a godly treatment,but not a cure.

The reason why I think it might not be necessary to finger all of the genetic mutations for pattern baldness is that this MIT team of researchers think they can treat age-related hearing loss with a drug combination to re-grow sensorineural inner ear hair cells: Researchers discover a drug combination that can regenerate hair cells in the inner ear. Clinical trials are scheduled to occur within the next 15 months, yet the locations and number of genes suspected of causing or contributing to age-related and nerve damaged hearing loss are still mostly unknown.

They exposed cells from a mouse cochlea, grown in a lab dish, to molecules that stimulate the Wnt pathway, which makes the cells multiply rapidly. ... “We used small molecules to activate the supporting cells so they become proliferative and can generate hair cells,” Yin says. ... At the same time, to prevent the cells from differentiating too soon, the researchers also exposed the cells to molecules that activate another signaling pathway known as Notch. ...Once they had a large pool of immature progenitor cells (about 2,000-fold greater than any previously reported), the researchers added another set of molecules that provoked the cells to differentiate into mature hair cells.

They've restored up to 80% of hearing loss in mice engineered to lack the cochlea's sensorineural inner hair cells. And now they think they can re-grow outer hair cells as well.

It may be possible that not all genetic pinholes in the garden hose need be ID'd and patched in order to "water the garden" so to speak. I think it could be that activating hair stem cells with a couple of small molecule drugs may work, in effect, as an electrical jumper wire to positively affect hair growth regardless of the polygenic nature of hair loss.

 

[BaldyBalderBald]

Possible, again this will be a treatment and not a cure.

You'll have to halt further hair loss after the regrow.

A "cure" is a myth, a lifetime treatment is a strong possibility

 

[NewUser]

We may have to slather some super goop on our heads every week, or perhaps once or twice every year. Who knows, really.

The future is rushing toward us now at a frenzied pace. 6 years tops.

 

[Kad]

Doubt there will be a cure anytime soon

 

[ALightInTheDark]

Fevipiprant : 2019
Darolutamide : 2019.

You will never loose your hair again.
Thank me later

 

[kiwipilu]

i think most ppl would be happy to count what u've just described as a 'cure'- if that's what it takes to regrow hair.
At least i would.

Definitely agree! If it's scientifically proven a treatment stops every kind of hair loss patterns for good(til death) and even give some regrowth(or little hair transplant as bonus for the sake of it) I would be more than happy to apply it every day as it takes few minutes(even apply it 10times).

Fevipiprant : 2019
Darolutamide : 2019.

You will never loose your hair again.
Thank me later

Luckily we will get our hands on such drug sooner..

 

[Trichosan]

@NewUser ('s), post above reminds us that research in cellular and molecular biology and genetics has advanced across several fields of scientific interest. Overlapping discoveries and shared data contribute to understanding now of the mechanisms involved in and solutions to hairloss. There is greater reason to be hopeful with everyday that passes by. I believe that we are past the point of random discovery and general science. The field of tissue regeneration and molecular control is now moving under it's own impetus and the days to the end of baldness will be measured in small increments now.

 

[Jonnyyy]

@NewUser ('s), post above reminds us that research in cellular and molecular biology and genetics has advanced across several fields of scientific interest. Overlapping discoveries and shared data contribute to understanding now of the mechanisms involved in and solutions to hairloss. There is greater reason to be hopeful with everyday that passes by. I believe that we are past the point of random discovery and general science. The field of tissue regeneration and molecular control is now moving under it's own impetus and the days to the end of baldness will be measured in small increments now.

The fact that some companies are getting close to cloning skin in order to test their products on human skin and not mice should tell us a lot about how close we are to killing this thing.

 

[Jonnyyy]

Definitely agree! If it's scientifically proven a treatment stops every kind of hair loss patterns for good(til death) and even give some regrowth(or little hair transplant as bonus for the sake of it) I would be more than happy to apply it every day as it takes few minutes(even apply it 10times).



Luckily we will get our hands on such drug sooner..

What do those two products do exactly, I looked one up and it seems to be out of phase 3 already?

 

[BaldyBalderBald]

What do those two products do exactly, I looked one up and it seems to be out of phase 3 already?

Fevipiprant is a PGD2 antagonist and regulates PGD2 levels activity in Chrt2 receptors. It may very well halt hair loss, as for getting significant regrowth ? No results were published so far, we have to wait and see.His weaker brother, Setipiprant was initially researched as a treatment for allergies and inflammatory disorders, particularly asthma, but despite being well tolerated in clinical trials and showing reasonable efficacy against allergen-induced airway responses in asthmatic patients, it failed to show sufficient advantages over existing drugs and was discontinued from further development in this application.

Darolutamide is an Androgen Receptor antagonist, never read anything about his efficacity, can't say anything.

 

[Jonnyyy]

Fevipiprant is a PGD2 antagonist and regulates PGD2 levels activity in Chrt2 receptors. It may very well halt hair loss, as for getting significant regrowth ? No results were published so far, we have to wait and see.His weaker brother, Setipiprant was initially researched as a treatment for allergies and inflammatory disorders, particularly asthma, but despite being well tolerated in clinical trials and showing reasonable efficacy against allergen-induced airway responses in asthmatic patients, it failed to show sufficient advantages over existing drugs and was discontinued from further development in this application.

Darolutamide is an Androgen Receptor antagonist, never read anything about his efficacity, can't say anything.

yea I don't think there's any magical drug that will completely bring back all lost hair that will be discovered anytime soon, I think we need to realize that the only ways would be Tsuji in the future and hair transplants now, all we really need is to halt the hairloss.

 

[BaldyBalderBald]

It could bring back those hairs, we only know that it inhibits hair growth.

I only wish they will pusblish some of their results, and we can be fixed about that, but nothing so far

 

[H]

Ya so changing your genes isnt going to regrow dead organs/hair follicles you might never lose another hair to dht sensitivity but your not going to sprout all your original hairs back they gone. No nucleotide or codon switcheroo is going to sprout that density back or at least im very skeptical of that outcome. Now I've read some of Tsujis book and the guy is pretty damn smart in my opinion and to the people who say "well even if they can give us hair itll be the bad type of hair we already lost" , do you guys think the team of researchers did not think about this or are not thinking about this? These guys are trying to give people their hair back and they forgot that something causes hair loss? Male pattern alopecia occurs when a hair papilla develops overexpression of a male hormone converting enzyme. "We produced hypocapillary cells of the occipital hair follicle, which do not produce this enzyme, cultured, swap hair papilla cells of the hair follicle at the hair removal site, and change the fate to normal hair follicle" straight from Organ Technologies website. I believe it has crossed their mind that even if you create a hair follicle for hair loss there's still a reason you had to create that hair follicle lol.

 

[vernon]

The fact that some companies are getting close to cloning skin in order to test their products on human skin and not mice should tell us a lot about how close we are to killing this thing.

we were also "getting close" to hair cloning in 2003. there are at least 10 years from "getting close" to actually offering a product/treatment on the market.

that ridiculous unfounded optimism is just gonna leave people even more frustrated

 

[Jonnyyy]

we were also "getting close" to hair cloning in 2003. there are at least 10 years from "getting close" to actually offering a product/treatment on the market.

that ridiculous unfounded optimism is just gonna leave people even more frustrated

Sorry man you're right mostly, gotta have at least a little bit of optimism, and sorry my post was wrong, a lot of labs already test on human cloned skin I was just unaware.

 

[ALightInTheDark]

yea I don't think there's any magical drug that will completely bring back all lost hair that will be discovered anytime soon, I think we need to realize that the only ways would be Tsuji in the future and hair transplants now, all we really need is to halt the hairloss.

I never talked about bring back your hairs. Just stop forever the loss.
If you hant to create hairneogenesis just wound + Topical 5-Aza + FGF9.

 

[Jonnyyy]

Ya so changing your genes isnt going to regrow dead organs/hair follicles you might never lose another hair to dht sensitivity but your not going to sprout all your original hairs back they gone. No nucleotide or codon switcheroo is going to sprout that density back or at least im very skeptical of that outcome. Now I've read some of Tsujis book and the guy is pretty damn smart in my opinion and to the people who say "well even if they can give us hair itll be the bad type of hair we already lost" , do you guys think the team of researchers did not think about this or are not thinking about this? These guys are trying to give people their hair back and they forgot that something causes hair loss? Male pattern alopecia occurs when a hair papilla develops overexpression of a male hormone converting enzyme. "We produced hypocapillary cells of the occipital hair follicle, which do not produce this enzyme, cultured, swap hair papilla cells of the hair follicle at the hair removal site, and change the fate to normal hair follicle" straight from Organ Technologies website. I believe it has crossed their mind that even if you create a hair follicle for hair loss there's still a reason you had to create that hair follicle lol.

I wonder if Tsuji knows that the biggest reason for hairloss i

I never talked about bring back your hairs. Just stop forever the loss.
If you hant to create hairneogenesis just wound + Topical 5-Aza + FGF9.

what does Hair Neogenesis do? Does it reverse hairloss or does it create new hairs?

 

[ALightInTheDark]

what does Hair Neogenesis do? Does it reverse hairloss or does it create new hairs?

Creates new hair. There is nothin like "reverse hairloss". To reverse hairloss you have to do multiple steps :
1) Block PDG2 DP2/CRTH2 and Dht locally to stop hairloss for good.
2) Wound + Topical 5Aza + FGF9 (Stemox/LiCl/Valproate Sodium) to create new hairs follicles
3) Grow that hair with minoxidil,Hydralazine,Growth factors,high vits regimen,PGE2 (topically,castor oil and sunburs),PGF2alpha,PGE1.
4) Consistancy.

 

[Jonnyyy]

Creates new hair. There is nothin like "reverse hairloss". To reverse hairloss you have to do multiple steps :
1) Block PDG2 DP2/CRTH2 and Dht locally to stop hairloss for good.
2) Wound + Topical 5Aza + FGF9 (Stemox/LiCl/Valproate Sodium) to create new hairs follicles
3) Grow that hair with minoxidil,Hydralazine,Growth factors,high vits regimen,PGE2 (topically,castor oil and sunburs),PGF2alpha,PGE1.
4) Consistancy.

So does follica plan on doing both or just create new hair?

 

[ALightInTheDark]

So does follica plan on doing both or just create new hair?

Create new hair and keep them. But nothin amazing about density