Is The Cure For This Disease Anywhere Close?

S Foote.

Experienced Member
Reaction score
67
The OP asked "Is The Cure For This Disease Anywhere Close? "

Not according to the widely accepted science, in the peer reviewed papers about in-vivo tissue growth controls. According to the accepted scientific norm here, hair follicle growth restriction research, is failing to take account of a basic growth control that must play a central role.

http://phys.org/news/2014-04-room-tissue-growth-cell-response.html

Non of the treatments currently being researched, are capable of getting around this growth control in the "actual" conditions of the balding Human scalp. If you consider the only study that demonstrated a significant re-enlargement of "Human" male pattern baldness follicles, this clearly demonstrates that these follicles have the built in ability to re-enlarge, given the right "external" conditions. This is the immuno mouse Human transplantation study, many here are aware of.

http://www.jaad.org/article/S0190-9622(02)61499-9/pdf

If nothing else, this study indicates that the cell based treatments intended to grow androgen "immune" follicles, are pointless and will fail to produce large follicles in the Human situation, as they have consistantly failed to do in many years of trying.

In my opinion, the concentration upon molecular and genetic studies alone can be very misleading. You always should consider the context in which biology/physiology actually functions. However the genes act to produce structures, these structures cannot defy the laws of physics! Often you dont need to know whats happening at the molecullar level, to understand a process of change. This I suggest is a case in point.

When you consider the principles involved in the external pressure based spatial growth controls linked above, against the accepted data in changes in hair growth, it becomes clear that this control is the common factor here.
I have challenged many scientists in hair research and general physiology, to go on the record and deny this major flaw in the current hair loss research, I just get a no comment. I have just made the same challenge to the organisers and scientists involved in the up coming conference in Japan.

If there are any scientists out there who are willing to go on the record, and deny this flaw in the current hair loss research, I would like to hear what they have to say?

Dont shoot the messenger here. Anyone can read the peer reviewed papers about tissue growth controls in-vivo, and see the flaw in current hair follicle miniaturisation research for thenselves.
 

resu

Senior Member
Reaction score
1,352
The cure will be prevention and cloning, I don't think we'll fully understand this condition or how to reverse it. I have big hopes for CRISPR but it's only for future generations.
 

Jonnyyy

Senior Member
My Regimen
Reaction score
823
The cure will be prevention and cloning, I don't think we'll fully understand this condition or how to reverse it. I have big hopes for CRISPR but it's only for future generations.
What do you think about Tsuji and his procedure?
 

resu

Senior Member
Reaction score
1,352
What do you think about Tsuji and his procedure?

Probably around 2020-2030 if they ever solve the issues with their approach. I only care about Breezula, everything else is smoke and mirrors. I got good results with minoxidil alone, just need an anti-androgen without horrible side-effects.
 

BaldyBalderBald

Banned
My Regimen
Reaction score
1,531
Probably around 2020-2030 if they ever solve the issues with their approach. I only care about Breezula, everything else is smoke and mirrors. I got good results with minoxidil alone, just need an anti-androgen without horrible side-effects.

Follica can be promising too, if they manage to get back a good density and if PGD2 antagonists are viable to halt hair loss and miniaturisation without messing with DHT
 

BaldyBalderBald

Banned
My Regimen
Reaction score
1,531
There is nothing promising about 25 hairs per cm2.

New patents got out since this number, i can't retrieve where this number was given in the first place.I'll wait for clinical trials results to give my final answer.

Only other thing to get back some hair is an expensive cloned hair grafting surgery in Japan, i'll pass on this and i don't know if Breezula will be able to get some regrowth, but i doubt it

If this is all science can do...
 

Jonnyyy

Senior Member
My Regimen
Reaction score
823
Probably around 2020-2030 if they ever solve the issues with their approach. I only care about Breezula, everything else is smoke and mirrors. I got good results with minoxidil alone, just need an anti-androgen without horrible side-effects.
I thought Breezula was a meme?
 

Jonnyyy

Senior Member
My Regimen
Reaction score
823
Nope mate, topical anti-androgen, hopefully will replace finasteride and avoid reducing bloodstream DHT, less to none side effects

http://www.cassiopea.com/activities/product-pipeline/breezula.aspx
That's awesome, a few questions, it says they're in phase 2 so they still need to finish that then phase 3 which could take years right? And another is there any anti dht topical similar to breezula I need something so I can try and hold my hair off until all these things come out.
 

ZZmop

Established Member
Reaction score
305
That's awesome, a few questions, it says they're in phase 2 so they still need to finish that then phase 3 which could take years right? And another is there any anti dht topical similar to breezula I need something so I can try and hold my hair off until all these things come out.

Last I saw they were aiming for 2021
 

BaldyBalderBald

Banned
My Regimen
Reaction score
1,531
That's awesome, a few questions, it says they're in phase 2 so they still need to finish that then phase 3 which could take years right? And another is there any anti dht topical similar to breezula I need something so I can try and hold my hair off until all these things come out.

Expected market release for Breezula is 2021, you can find their pipeline here :
http://www.cassiopea.com/activities/product-pipeline.aspx

There is another experimental one, not yet release, called Ru58841, Hellouser just made a well done usage guide for it :
https://www.gourmetstylewellness.com/interact/threads/hellousers-complete-ru58841-usage-guide.109075/


In any case, i see that you're already on finasteride, this means your DHT level are already low, don't know if you can use both for better results, this is supposed to be release to stop finasteride and not going systemic
 

Jonnyyy

Senior Member
My Regimen
Reaction score
823
Expected market release for Breezula is 2021, you can find their pipeline here :
http://www.cassiopea.com/activities/product-pipeline.aspx

There is another experimental one, not yet release, called Ru58841, Hellouser just made a well done usage guide for it :
https://www.gourmetstylewellness.com/interact/threads/hellousers-complete-ru58841-usage-guide.109075/


In any case, i see that you're already on finasteride, this means your DHT level are already low, don't know if you can use both for better results, this is supposed to be release to stop finasteride and not going systemic
Holy f***, 2021? I might have two hairs left at that point, I got off the finasteride too many side effects.
 

CharAblaze

Established Member
My Regimen
Reaction score
439
Holy f***, 2021? I might have two hairs left at that point, I got off the finasteride too many side effects.
No one can tell how many hairs you'll have left, some dudes maintain after they recede quite a lot without using anything (it's true, for some it just stops or slows down).
What's your stage?
I got to Norwood 2.5-3 really fast (like in 6 months), then slowed down significantly, 4 years later entering NW4.
 

Jonnyyy

Senior Member
My Regimen
Reaction score
823
No one can tell how many hairs you'll have left, some dudes maintain after they recede quite a lot without using anything.
What's your stage?
I got to Norwood 2.5-3 really fast (like in 6 months), then slowed down significantly, 4 years later approaching NW4.
I would say Norwood 3 back is starting to thin out fast, couldn't tell a few months ago definitely can now.
 

mr_robot

Experienced Member
Reaction score
385
New patents got out since this number, i can't retrieve where this number was given in the first place.I'll wait for clinical trials results to give my final answer.

Only other thing to get back some hair is an expensive cloned hair grafting surgery in Japan, i'll pass on this and i don't know if Breezula will be able to get some regrowth, but i doubt it

If this is all science can do...

That number is from Follica itself and is not pulled out from the sky. There are hundreds of hair patents out there that don't work, patents mean nothing unless there are trials to back them up with hard results.

Hair cloning is probably the only realistic way to increase hair density with maybe replicel thickening existing hairs.

Breezula like all inhibitors can not by its nature cause new regrowth, it may be helpful for hairs that have not reached the point of no returned but not much else.
 

BaldyBalderBald

Banned
My Regimen
Reaction score
1,531
That number is from Follica itself and is not pulled out from the sky. There are hundreds of hair patents out there that don't work, patents mean nothing unless there are trials to back them up with hard results.

Hair cloning is probably the only realistic way to increase hair density with maybe replicel thickening existing hairs.

Breezula like all inhibitors can not by its nature cause new regrowth, it may be helpful for hairs that have not reached the point of no returned but not much else.

I know this comes from Follica, but again i can't retrieve the source, do you have it ? I mean real trial results

New patents got out from Follica itself btw, and they are still in trial, just wait for the final results maybe ?

Tsuji can be good, but still considered as an hair transplant, still too dependent on the abilities of the surgeon for me.

Point of no return ? Wtf is that ? Follicle death ? Can you please elaborate ? Do you have any research paper to backup this claim ? How can you explain those who takes the tranny route and get almost all back even long-term lost ones ?
 

Kev123

Experienced Member
My Regimen
Reaction score
387
Forget the cure, i'm wondering if an actual good working treatment better than the big 3 is close.
 

S Foote.

Experienced Member
Reaction score
67
Of the current lines of research, the only one that has any real potential is Histogen's HSC. This is because of a factor anyone can see for themselves.

As I said in my post above, hair follicle enlargement "within" the dermal tissue, must be subject to the normal spatial growth controls. This control is also a basic safety feature in tissue growth, and any cell modification that can get around this control, would just not get approved because it is inherently dangerous.

The only safe and effective way to enlarge hair follicles, is to reduce the tissue pressure around them. Any treatment that does this will also do something else that can be seen. As the pressure reduces the tissue shrinkage will cause crazing and fine wrinkling of the skin. This is the major complaint of using Minoxidil on these forums, bad skin and wrinkles.

There are a couple of pictures on the Histogen site of before and after the use of HSC. The after pic clearly shows this effect on the skin, demonstrating that HSC is reducing the tissue pressure.

HSC 2.jpg
 
Top