@Falco4758 You are right to be highly cautious of using this drug. I strongly recommend reading this thread before making any further decision regarding finasteride
https://www.gourmetstylewellness.com/intera...-overview-of-this-devastating-disease.123852/
FDA does not approve drugs based on users’ reviews. They rely on scientific, properly operated double-blind trials and experiments to objectively conclude a drug’s safety profile.
It's true, the FDA does rely on trial data to assess a drug's safety profile. Unfortunately, some drugs pass initial safety approval tests only to subsequently be proved to be harmful, sometimes seriously so, to a subset of users. This results in label changes, including 'black box' warnings and even withdrawal from the market. As one can see from this list of withdrawn drugs
https://en.wikipedia.org/wiki/List_of_withdrawn_drugs, there are well over a hundred instances of drugs being initially deemed safe, only to then be withdrawn because they were not safe.
Furthermore, the trustworthiness and veracity of the data that was submitted by Merck to the FDA has been openly dismissed in peer reviewed, published literature as recently as last month
Given that considerable level of bias is introduced in many of these studies [on finasteride] since large number of these clinical trials were funded and administered by the drug manufacturers, it is paramount that clinicians do their due diligence and not fall for the slogan, “these drugs are well tolerated and safe.”
Given the level of bias due to conflict of interest, it is not surprising that the level of harm is tampered down significantly.
Source:
https://www.sciencedirect.com/science/article/pii/S0015028219325993
There is good reason that Merck's data has been dismissed. A recent article from Reuters uncovered evidence that Merck manipulated their trial data and covered up long term effects that could occur in some users
https://www.reuters.com/investigates/special-report/usa-courts-secrecy-propecia/. Much of this has only now been revealed to the public because Reuters' journalists were able to unredact sections of sealed court documents from a class action lawsuit against Merck. As shown in Reuters' investigative report, there were men
in the original trials who developed sexual side effects which persisted after the drug was withdrawn and Merck doesn't know if they ever resolved
"In the fine print of Propecia's product information material there's a section called clinical trials experience. You won't find these results there. Merck doesn't disclose this data on the label that is shared with doctors and patients."
It's worth bearing in mind, these are just in regards to sexual side effects, which are just a portion of the symptoms men can and do experience with PFS.
The redacted motion argues that Merck not only underreported the number of men who experienced sexual dysfunction while taking Propecia, but also concealed the duration of those problems. Citing the Merck analyst’s memo, the motion says that of the 23 study subjects who experienced sexual side effects during the last three years of the study, seven continued to experience symptoms when they completed it. The symptoms of nine others resolved after they stopped taking the drug, but the time it took was unknown, the motion says. And of the six men who dropped out of the study, it says, one still had symptoms at least 66 days after stopping treatment.
Merck didn’t know if some of these men’s symptoms resolved, Kaufman said in a deposition.
None of this data described in the plaintiffs’ motion was included on the revised 2002 label. Instead, Merck made a small but significant change to the label’s language: Symptoms stopped in “men” who went off the pills, the label now said, rather than “all men.”
Readers here can make up their own minds here whether they think Merck were acting in the best interests of people's health when they made such a slight of hand amendment to the label.
The full video report can be viewed here
the chances of sided are minimal. if you experience any stop taking the drug.
Stay away from scare stories and take it, if you experience sides so bad that they take precedence over your hair then just stop.
Or 2) you try finasteride, you get sides, you quit at the first signs, you recover and either way you are at peace for trying it and seeing your unique reaction to it.
I'm afraid this is outdated advice and is not accurate. If you have the predisposition to develop Post Finasteride Syndrome, once the condition has been induced by the drug, one cannot simply stop the drug and have the problem go away. This is identical advice which I read on this forum before I decided to take finasteride. I developed symptoms relating to my sleep within hours of my first dose of the drug. I continued to take the drug for another three days before I discontinued due to moderate numbing in the glans of my penis, sleep disturbances and testicular discomfort. I had taken four doses of 0.25 mg for a total of approximately 1 mg. Three days after the last dose I experienced what is referred to as the "crash". What followed in the months after was a nightmare from another dimension, an abomination for the soul to endure. There were too many symptoms to list here. I can assure you that it was far more than sexual symptoms (which I also experienced). It's nearly two years since I took 1 mg of finasteride and I still have a litany of side effects I have to deal with daily. I am no longer able to work because of them.
For the record, a 2018 literature review on the disease concluded
The occurrence of persistent adverse sexual, physical, neurological, and psychiatric side effects after 5α-reductase inhibitor is well supported by the existing data.
Source:
https://link.springer.com/article/10.1007/s11930-018-0163-4
Primary data from a 2017 study found
In patients treated with finasteride for male pattern hair loss, persistent side effects may occur.
Erectile dysfunction and abnormal somatosensory evoked potentials of the pudendal nerve were reported.
Major depressive disorder and altered levels of neuroactive steroids were observed.
Source:
https://www.sciencedirect.com/science/article/abs/pii/S0960076017301024
Another study
provides the first evidence of a molecular objective difference between patients with long-term adverse sexual effects after finasteride use versus drug untreated healthy controls in certain tissues.
Source:
https://www.ncbi.nlm.nih.gov/pubmed/24959691