This could be related to people reading about Seti before they use it, and it's all anecdotal, but the report that DP2 antagonists completely stops itching was the most common out of any positive effect listed. I looked back at some of th Seti posts from a few years ago and everyone seemed to be in agreement on that one point (without actually confirming it with each other, they were in different threads.) This is part of why I think that Seti might be affecting the sebacious glands or be doing at least something. I don't know for sure though, very loose evidence.