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Good, I didn't expect anything more from you.
Spoiler: at the end of my post there are the news I was talking about.
Italian Hair Loss Lotion To Hit The Market In 2016
- Thread starter paleocapa89
- Start date
Good, I didn't expect anything more from you.
Spoiler: at the end of my post there are the news I was talking about.
- Reaction score
- 8,250
Good, I didn't expect anything more from you.
Spoiler: at the end of my post there are the news I was talking about.
Duh. LOL
- Reaction score
- 439
The results in Androgenetic Alopecia after 6 months were excellent Brotzu claims according to Google Translate.
I also got that it stops hair loss, but the regrowth depends on the extent of baldness.
Brotzu also expects this to release fairly soon given the data they collected.
Good, I didn't expect anything more from you.
Spoiler: at the end of my post there are the news I was talking about.
No offense, man but that was uncool. Why not just tell us what's happening? We appreciate your input a lot and all you bring to this thread, but to dangle news in our faces without telling us is kinda not cool
- Reaction score
- 8,250
That is ALL I was saying--never implied or wrote half the sh*t he wrote.
This is so fresh. Haven't ever heard this from Brotzu before.
- Reaction score
- 11,939
Google translate of the interview posted by Mr. 7th:
[It's John Brotzu in English lol].
Second Interview with John Brotzu on her hair lotion.
June 13, 2017/0 Comments in pharmacology / from stefano
Second Interview with John Brotzu on Hair Lotion.
Dr. Brotzu, in his interventions, has always stressed how the lotion bases its effectiveness on the synergic action of DGLA and Equolo, and has specified that in his experiments only DGLA or Equolo alone did not stop the fall. So how did you initially notice the effectiveness of these components, since the formulation was different in the beginning? How ever did her nurse who had asked to try the remedy on her scalp affected by Androgenetic Alopecia had results that led to a deepening of the question? And why, then, was the Equolo added later?
The prostaglandin E1 (PGE1) is a molecule synthesized by our body. It determines vasodilation by acting on the elasticity of endothelial cells, their function, their reproductive capacity, their elasticity, and stimulates the production of Vascular Endothelial Growth Factor (VEGF). PGE1 is used in arterial vasculopathy therapy especially in those with a microangiopathy (diabetes). It has the defect of having a very short half-life, less than a minute when injected endovine. DGLA is a 20 carbon atomic NEFA and is the precursor of PGE1.
The activity of PGE1 and DGLA on endothelial cells has been demonstrated in many years of research by a huge number of researchers long before PGE1 was used as a drug.
Given the short half-life of PGE1, when injected, we performed studies to obtain a greater stability of the molecule by carrying it from liposomes. We have performed many studies on both healthy rats and diabetic rats and humans, achieving excellent results.
The use of PGE1 and DGLA in Alopecia forms is of a second period.
At this point it should be pointed out that Alopecia Androgenetica (Androgenetic Alopecia) and Alopecia Areata (AA) and Totalis (AT) have different etiologic causes, while being the same aesthetic result.
Androgenetic Alopecia is predominantly the result of hormonal changes in which dihydrotestosterone appears to be the primary responsible. It acts both on the bulb and microcirculation, damaging the endothelial cells. The combined action of dihydrotestosterone on the bulb and endothelial cells of the capillaries that arrive at the bulbs causes a damage to these.
AA and AT may have many and many other pathological causes such as: genetic, inflammatory, thyroid hyperactivity ect. The causes that may cause hair loss are many, but basically are the endothelial cells of the capillaries, which carry what is necessary for hair metabolism, to be affected and damaged. Because of the many causes of these AA and AT disorders, it is not possible to generalize.
The lotion we set up acts on endothelial cells of the capillaries that arrive at the hair bulbs. In fact, cationic liposomes of diameter around 100 nm can penetrate into the dermis and reach the endothelial cells and release the molecules they carry at that level.
DGLA is a molecule that we can not assume because it exists already in nature and because it is part of many oils. It must be considered that it is the molecule that we assimilate with nutrition and transform into PGE1.
Equation by inhibiting 5-α-reductase prevents testosterone from becoming dihydrotestosterone. Since the delivered amount of liposomes is very small, it can not create other problems and only acts locally.
The nurse is the first person to use the lotion about 7 years ago.
In your interventions, it has shown how Minoxidil can only act on the pericitum, and not beyond. You claim that PGE1 and DGLA have effect on endothelial cells, but why? What is the characteristic that allows DGLA of the lotion to act on them and not just on pericytes? Minoxidil formulations are known to be transported by liposomes or nanosomes, but they do not, according to the testimonials, have yielded tangibly superior results to the traditional hydroalcoholic formulation. By relying on your specialist knowledge of the cardiovascular system, do you believe that the mechanism of vasodilation of Minoxidil may somewhat inflate or counteract the work of the DGLA of the lotion in a hypothetical joint therapy for Androgenetics? Could it be abandoned, for who is already in therapy with it, to place only the lotion, without dramatic consequences for the follicles?
Minoxidil is a vasodilator that acts on pericytes but not on endothelial cells that have other functions and are very different from organs to organs. Minoxidil acts in less than 30% of Androgenetic Alopecia
More about this
[It's John Brotzu in English lol].
Second Interview with John Brotzu on her hair lotion.
June 13, 2017/0 Comments in pharmacology / from stefano
Second Interview with John Brotzu on Hair Lotion.
Dr. Brotzu, in his interventions, has always stressed how the lotion bases its effectiveness on the synergic action of DGLA and Equolo, and has specified that in his experiments only DGLA or Equolo alone did not stop the fall. So how did you initially notice the effectiveness of these components, since the formulation was different in the beginning? How ever did her nurse who had asked to try the remedy on her scalp affected by Androgenetic Alopecia had results that led to a deepening of the question? And why, then, was the Equolo added later?
The prostaglandin E1 (PGE1) is a molecule synthesized by our body. It determines vasodilation by acting on the elasticity of endothelial cells, their function, their reproductive capacity, their elasticity, and stimulates the production of Vascular Endothelial Growth Factor (VEGF). PGE1 is used in arterial vasculopathy therapy especially in those with a microangiopathy (diabetes). It has the defect of having a very short half-life, less than a minute when injected endovine. DGLA is a 20 carbon atomic NEFA and is the precursor of PGE1.
The activity of PGE1 and DGLA on endothelial cells has been demonstrated in many years of research by a huge number of researchers long before PGE1 was used as a drug.
Given the short half-life of PGE1, when injected, we performed studies to obtain a greater stability of the molecule by carrying it from liposomes. We have performed many studies on both healthy rats and diabetic rats and humans, achieving excellent results.
The use of PGE1 and DGLA in Alopecia forms is of a second period.
At this point it should be pointed out that Alopecia Androgenetica (Androgenetic Alopecia) and Alopecia Areata (AA) and Totalis (AT) have different etiologic causes, while being the same aesthetic result.
Androgenetic Alopecia is predominantly the result of hormonal changes in which dihydrotestosterone appears to be the primary responsible. It acts both on the bulb and microcirculation, damaging the endothelial cells. The combined action of dihydrotestosterone on the bulb and endothelial cells of the capillaries that arrive at the bulbs causes a damage to these.
AA and AT may have many and many other pathological causes such as: genetic, inflammatory, thyroid hyperactivity ect. The causes that may cause hair loss are many, but basically are the endothelial cells of the capillaries, which carry what is necessary for hair metabolism, to be affected and damaged. Because of the many causes of these AA and AT disorders, it is not possible to generalize.
The lotion we set up acts on endothelial cells of the capillaries that arrive at the hair bulbs. In fact, cationic liposomes of diameter around 100 nm can penetrate into the dermis and reach the endothelial cells and release the molecules they carry at that level.
DGLA is a molecule that we can not assume because it exists already in nature and because it is part of many oils. It must be considered that it is the molecule that we assimilate with nutrition and transform into PGE1.
Equation by inhibiting 5-α-reductase prevents testosterone from becoming dihydrotestosterone. Since the delivered amount of liposomes is very small, it can not create other problems and only acts locally.
The nurse is the first person to use the lotion about 7 years ago.
In your interventions, it has shown how Minoxidil can only act on the pericitum, and not beyond. You claim that PGE1 and DGLA have effect on endothelial cells, but why? What is the characteristic that allows DGLA of the lotion to act on them and not just on pericytes? Minoxidil formulations are known to be transported by liposomes or nanosomes, but they do not, according to the testimonials, have yielded tangibly superior results to the traditional hydroalcoholic formulation. By relying on your specialist knowledge of the cardiovascular system, do you believe that the mechanism of vasodilation of Minoxidil may somewhat inflate or counteract the work of the DGLA of the lotion in a hypothetical joint therapy for Androgenetics? Could it be abandoned, for who is already in therapy with it, to place only the lotion, without dramatic consequences for the follicles?
Minoxidil is a vasodilator that acts on pericytes but not on endothelial cells that have other functions and are very different from organs to organs. Minoxidil acts in less than 30% of Androgenetic Alopecia
More about this
br1
Senior Member
- Reaction score
- 2,163
He also said, when asked this question before, that he doesn't know.. because Fidia won't tell..
- Reaction score
- 439
You forgot 2nd part:
Even with regard to this aspect, vasodilatation is characteristic of DGLA, among its many other important qualities; But would this beneficial effect be reduced over time due to a possible 'habit' of the circulatory system being continuously stimulated by causes outside the system? In other words, according to your experiments, is the continuity of efficacy of DGLA over the long term, in all the diseases of the treated hair, desirable?
There is no addiction to DGLA.
From her initial experiments on Androgenetic Alopecia and her statements, does she feel that the lotion is the only component of a therapy without being accompanied by other drugs? There are so many patients, including those who write, who suffer from side effects that are heavily affected by current treatments, and would like to abandon them in favor of your product. Could they do so with relative security on the outcome?
In patients with Androgenetic Alopecia, the results after 6 months of therapy were excellent.
On subjects who do not suffer from side effects or who want to be more careful of Androgenetics, it may be useful to accompany the lotion, according to your opinion, also a 5-alpha reductase inhibitor (Finasteride, Dutasteride, Expr. The substantial abatement of DHT by these drugs could be of further help to the power of the lotion, also given the different mechanism of fighting DHT itself between S-Equolo and Finasteride?
I would never advise those vascular surgeons.
Against this latest topic, in one of your interviews, you say that the fall of the fall was the simplest goal to get. By virtue of this, at least on Androgenetics, would it be too ambiguous to expect total (or near) maintenance of capillary wealth from the lotion, even over the long term? How does your remedy, from its initial experiments, in preventing the frontal artery due to Androgenetic Alopecia?
The results that tell us that logically the positive response varies from subject to subject and depends on how long the Androgenetic Alopecia has started
7- At the SITRI meeting in November he presented the amazing results on Areata. Are your experiments in this subject terminated or need to be continued? According to you, is the fact that the lotion has proved to be so effective on Areata is already a security for its future marketing? Could we think of seeing her one day on the shelves, regardless of the results of the pharmaceutical company's Androgenetic Alopecia experiments?
In your previous interviews, he stated that there were, in your view, no apparent reasons for preventing the marketing of the remedy. In the light of the latest official statement of the pharmaceutical firm, do you personally have the same opinion as before? If not, why?
The pharmaceutical company, which is very serious, must carry out many tests before placing any product on the market. We ran a series of tests and studied the stability of the product over time. If manufactured today must be valid for many months. Given the data we have, I think the pharmaceutical company will put it on the market fairly soon.
The problem is that whoever starts using the lotion will have to use it always, because the lotion prevents the effects of pathological stimuli, but does not eliminate it.
How can it stop hair from falling, but whether or not it stops Androgenetic Alopecia depends on the person? Or it is just another GT nonsense shenanigans?
- Reaction score
- 11,939
I don't see any new information in that interview, only chuckles due to the fact that google has not yet perfected translation.
Which leads to existential dread as I realize that within a few years they'll be translating better than any human who has ever lived in the past or will live in the future.
Which leads to existential dread as I realize that within a few years they'll be translating better than any human who has ever lived in the past or will live in the future.
Very interesting! Thank you @The7thSense. Did I understand it correctly that the Doctor does not recommend finasteride in combination with this lotion? This is great news! You know why? It means that the Doctor is still very confident to say that from his point of view finasteride is not needed... Maybe he just said that he is a vascular surgeon and doesn't really know but for me it'S important that he did NOT recommend finasteride as an addition to the lotion.
It seems that they solved the stability issues:
"The pharmaceutical company, which is very serious, must carry out many tests before placing any product on the market. We ran a series of tests and studied the stability of the product over time. If manufactured today must be valid for many months. Given the data we have, I think the pharmaceutical company will put it on the market fairly soon."
It seems that they solved the stability issues:
"The pharmaceutical company, which is very serious, must carry out many tests before placing any product on the market. We ran a series of tests and studied the stability of the product over time. If manufactured today must be valid for many months. Given the data we have, I think the pharmaceutical company will put it on the market fairly soon."
- Reaction score
- 311
Finally, I can say that we will have a new treatment, in the next 3-5 years
- Reaction score
- 324
Thank god I started minoxidil and finasteride, this is getting out of control, if I were to wait for this lotion I'd be pretty fucked right now.
But I still hope for this to be released and that I can quit finasteride, I don't want to take it for more than a couple of years tbh.
But I still hope for this to be released and that I can quit finasteride, I don't want to take it for more than a couple of years tbh.
br1
Senior Member
- Reaction score
- 2,163
He Google-translated-clearly stated he never prescribed it while he was practicing medicine.
- Reaction score
- 421
2018 best case scenario
- Reaction score
- 957
This is all great and all, but I hope to hear some official word on this from Fidia themselves.
..Supress the hype supress the hype..
..Supress the hype supress the hype..
- Reaction score
- 439
... Supress the bald supress the bald...