michael barry
Senior Member
- Reaction score
- 14
Steve,
thought Id drop by again for the sake of seeing anyone getting to save time on baldness. The emerging view in many quarters on baldness is this. There are 4 genes found thusfar having to do with baldness. Scientists think that there is a fifth one for sure, and perhaps a few more. Guys who male pattern baldness usually have extra androgen receptors on hairs in the parts of the scalp that go bald first. Usually the hormone DHT, made by 2 enzymes called alpha-five reductase type one and alpha-5 reductase type 2, bind with the androgen receptors.
When they do, the dermal papilla of the follicle releases growth inhibitors to the rest of the follicle's parts. Keratinocytes slow cell growth, outer root sheath, other parts of the follicle slow down some, and make a smaller follicle.
But this doesnt seem to be the "killer of the follicle though", eventually the immune system begins to see the predisposed follicle as a "foreign body" and tries to kill it. It releases superoxides and a few other growth inhibitors (like TGF-beta 1, etc) and damages the follicle, and the very close surrounding skin. The superoxides provide oxidative stress throughout the entire body in a person and are why folks age at the cellular level. So the hair and scalp skin around in us balding guys ends up ageing a little fast too. THe scalp of the area where hairs are shedding is usually a littel reddish and inflammed from the immuno attack. This leads to scar tissue around the follicle eventually. The follicle usually has a one or two intermediate cycles where it makes a smaller hair, then all it can make is a tiny vellus hair. However, its been shown that a large follicle can be recycled into a vellus hair in just one cycle.
If I were starting a regimine, I'd get on propecia to cut DHT of the Type 2 variety. This website advises the "big 3" which are propecia, nizoral shampoo, and minoxidil.
The only topical anti-DHT product that gourmetstylewellness.com really seems to believe in strongly is revivogen. Its supposed to use fatty acids to cut DHT in the scalp of the type one and two variety. There is a topical dutasteride sold at lipoxidil.com, but I havent gotten much feedback from users on that stuff yet. IF a guy hasnt lost much hair, or is just seeing some temple recession, cutting DHT/blocking androgen receptors or both proboably will allow him to keep the hair he has for a long time. If he's lost hair in the past couple of years, therefore the immuno attack has taken/is taking place......he'll proboably have to try minoxidil and an SOD or both in conjuntion with the anti=DHT routine to get that hair back and keep it. What you regrow with minoxidil, has to be kept up with minoxidil or youll re-lose it.
If I were afraid of an androgen receptor blocker....Id proboably give propecia+revivogen topically a shot.
If I werent, Id try propecia+fluridil or spironolactone. spironolactone has to be used twice a day though, because it gets diluted after 8 hours. Dr. Lee and Dr. Klein (web search em') both sell spironolactone/minoxidil combo's on their sites that dont smell so bad. spironolactone alone and especially combined with minoxidil really stinks unless a fragrant additive is used in the mix. Some guys mix their own, but have to apply spray cologne over it, or look out.
The SOD's on the market are listed in the above post. Dr. Proctor's shampoo and Prox-N have a minoxidil-like compound in them that is a nitric oxide releaser and helps get microcapillaries to regrow just like minoxidil (but they do not open potassium channels for intercellular communication, and help inhibit collagen formation like minoxidil does). That stuff is on that guys website. He's a little pricey, but hairloss is all he researches.
If I were just looking into hairloss though Steve, Id get on propecia (some fear dutasteride may have long term consequences of blocking almost all of your DHT production......although no known use in adult males for DHT has been found yet other than growing your prostate gland and making your hair fall out, it may be good for something we dont know about yet). Id use Nizoral twice a week, because youre gonna shampoo anyway. I'd use either and anti-DHT topical (revivogen, crinagen or try a receptor blocker like spironolactone, fluridil, or even flutamide.....but you have to watch for sides on flutamide because thats serious stuff). I might use a SOD also. Folligen, from the inventor of tricomin, is supposed to be used every other night, and a 40$ bottle would proboably last most men a full year. Cheap. The others are dailies and more pricey.
Id consider minoxidil last, because even though it works best. That is a commitment. One internal and two topicals isnt so bad though.
By the way. Its good to take a multivitamin of some kind. Flaxseed oil helps fight internal inflammation, MSM is good for hair growth and reduced production of sebum (DHT is in hair oil.....you want to make less of that) and high fat diets and especially fat from saturated animal sources with the particular emphasis on fatty red meat and fatty dairy....may stimulate the liver to make a little more alpha five type two reductase enyzme, and thus more DHT. Vitamin b6 and one of the soy isoflavones help you make LESS androgen receptors. So if youre gonna supplement.....those are good places to start.
I hope you remember this stuff and tell other guys just starting to look at hairloss about the ideas. I really wish WEBmd etc. had GOOD info on hairloss and a guy didnt have to look all over the net to find bits and pieces and put them together. This site, run by a guy named Kevin Rands, has some good info on it and especially in the resource library here at gourmetstylewellness.com if youve got some time to spend on it. I look a few things up while I watch TV during commercials and have learned some. At least enough that I think its hard for bogus new products to trick me with BS> Good luck
thought Id drop by again for the sake of seeing anyone getting to save time on baldness. The emerging view in many quarters on baldness is this. There are 4 genes found thusfar having to do with baldness. Scientists think that there is a fifth one for sure, and perhaps a few more. Guys who male pattern baldness usually have extra androgen receptors on hairs in the parts of the scalp that go bald first. Usually the hormone DHT, made by 2 enzymes called alpha-five reductase type one and alpha-5 reductase type 2, bind with the androgen receptors.
When they do, the dermal papilla of the follicle releases growth inhibitors to the rest of the follicle's parts. Keratinocytes slow cell growth, outer root sheath, other parts of the follicle slow down some, and make a smaller follicle.
But this doesnt seem to be the "killer of the follicle though", eventually the immune system begins to see the predisposed follicle as a "foreign body" and tries to kill it. It releases superoxides and a few other growth inhibitors (like TGF-beta 1, etc) and damages the follicle, and the very close surrounding skin. The superoxides provide oxidative stress throughout the entire body in a person and are why folks age at the cellular level. So the hair and scalp skin around in us balding guys ends up ageing a little fast too. THe scalp of the area where hairs are shedding is usually a littel reddish and inflammed from the immuno attack. This leads to scar tissue around the follicle eventually. The follicle usually has a one or two intermediate cycles where it makes a smaller hair, then all it can make is a tiny vellus hair. However, its been shown that a large follicle can be recycled into a vellus hair in just one cycle.
If I were starting a regimine, I'd get on propecia to cut DHT of the Type 2 variety. This website advises the "big 3" which are propecia, nizoral shampoo, and minoxidil.
The only topical anti-DHT product that gourmetstylewellness.com really seems to believe in strongly is revivogen. Its supposed to use fatty acids to cut DHT in the scalp of the type one and two variety. There is a topical dutasteride sold at lipoxidil.com, but I havent gotten much feedback from users on that stuff yet. IF a guy hasnt lost much hair, or is just seeing some temple recession, cutting DHT/blocking androgen receptors or both proboably will allow him to keep the hair he has for a long time. If he's lost hair in the past couple of years, therefore the immuno attack has taken/is taking place......he'll proboably have to try minoxidil and an SOD or both in conjuntion with the anti=DHT routine to get that hair back and keep it. What you regrow with minoxidil, has to be kept up with minoxidil or youll re-lose it.
If I were afraid of an androgen receptor blocker....Id proboably give propecia+revivogen topically a shot.
If I werent, Id try propecia+fluridil or spironolactone. spironolactone has to be used twice a day though, because it gets diluted after 8 hours. Dr. Lee and Dr. Klein (web search em') both sell spironolactone/minoxidil combo's on their sites that dont smell so bad. spironolactone alone and especially combined with minoxidil really stinks unless a fragrant additive is used in the mix. Some guys mix their own, but have to apply spray cologne over it, or look out.
The SOD's on the market are listed in the above post. Dr. Proctor's shampoo and Prox-N have a minoxidil-like compound in them that is a nitric oxide releaser and helps get microcapillaries to regrow just like minoxidil (but they do not open potassium channels for intercellular communication, and help inhibit collagen formation like minoxidil does). That stuff is on that guys website. He's a little pricey, but hairloss is all he researches.
If I were just looking into hairloss though Steve, Id get on propecia (some fear dutasteride may have long term consequences of blocking almost all of your DHT production......although no known use in adult males for DHT has been found yet other than growing your prostate gland and making your hair fall out, it may be good for something we dont know about yet). Id use Nizoral twice a week, because youre gonna shampoo anyway. I'd use either and anti-DHT topical (revivogen, crinagen or try a receptor blocker like spironolactone, fluridil, or even flutamide.....but you have to watch for sides on flutamide because thats serious stuff). I might use a SOD also. Folligen, from the inventor of tricomin, is supposed to be used every other night, and a 40$ bottle would proboably last most men a full year. Cheap. The others are dailies and more pricey.
Id consider minoxidil last, because even though it works best. That is a commitment. One internal and two topicals isnt so bad though.
By the way. Its good to take a multivitamin of some kind. Flaxseed oil helps fight internal inflammation, MSM is good for hair growth and reduced production of sebum (DHT is in hair oil.....you want to make less of that) and high fat diets and especially fat from saturated animal sources with the particular emphasis on fatty red meat and fatty dairy....may stimulate the liver to make a little more alpha five type two reductase enyzme, and thus more DHT. Vitamin b6 and one of the soy isoflavones help you make LESS androgen receptors. So if youre gonna supplement.....those are good places to start.
I hope you remember this stuff and tell other guys just starting to look at hairloss about the ideas. I really wish WEBmd etc. had GOOD info on hairloss and a guy didnt have to look all over the net to find bits and pieces and put them together. This site, run by a guy named Kevin Rands, has some good info on it and especially in the resource library here at gourmetstylewellness.com if youve got some time to spend on it. I look a few things up while I watch TV during commercials and have learned some. At least enough that I think its hard for bogus new products to trick me with BS> Good luck
