Men With Persistent Sexual Symptoms After Finasteride Show No Evidence Of Androgen Deficiency

[Alk]

I just know I'm completely fucked up and am desperate to feel better. It feels like I have dementia.

finasteride lowers Allopregnanolone in the brain, low levels of Allopregnanolone have been shown with people who have Alzheimer's and Dementia and major depression.

Some people's systems can handle the changes but others don't. From all of my PFS research, low Allopregnanolone is responsible for the mental and cognitive side effects.

There have been various theories of how to raise them back up again. Apparently SSRI's raise it significantly but SSRI'S have a whole other set of side effects including ED.

What a cluster f***..

I feel for you because you tried to save you hair but instead you got these sides. But truthfully you need to go on propecia help and read. Look at the studies they post and then look on google for the pre trials and understand what we know so far about pfs.

Finasteride barely inhibits 5 ar1 in the brain. It inhibits 5ar 2 which is in the spine and maybe thats where the problem is. dutasteride inhibits all 5ar and yet we do hear about less sides from dutasteride. Even stranger is this study which seems to state that hormones and 5ar are normal in these pfs sufferers. Many people take finasteride and have no sides.

Taking a ssri is not a good idea unless perscribed and even then id question them. Ssri's are know to cause similiar symptoms to pfs and they event have their own post syndrome.

The best thing u can do is the protocol.

 

[michel sapin]

damn man you start to sound crazy , you should go to propecia help .
man really , propecia leaves the sytem in two week .
the obly irreversible sides is gyno .

 

[ahmed wolf]

wh

I'm am going to start CDNUTS protocol after Christmas.

Lots of guys have been saying Sorghum is helping with their symptoms.

It's an African grain which is very androgenic that had been shown to significantly increase 5ar activity. As well as supplementing Creatine. I'm a lifter and used to use Creatine in the past. It significantly raises DHT levels up to 57%

It's just hard to weight training when you are brain fogged and feeling brain dead 24/7.

I thought this drug could cause sexual side effects. I was never aware the cognitive and mental damage it could do...

So healthy diet, weight training intensively to boost Testosterone, Sorghum to raise 5ar activity, and creatine for a dht increase.

If that gets me nowhere I will do CDNUTS protocol.

what is CDNUTS protocol?

 

[ahmed wolf]

di

Or try supplementing with DHT prohormones. The issue is the 5ar enzyme might have been damaged from finasteride and T will not convert to DHT no matter what you do.[/QUOTE
do a dht test to know ur levels
and creitin wont do nothing for ur dht

 

[ahmed wolf]

damn man you start to sound crazy , you should go to propecia help .
man really , propecia leaves the sytem in two week .
the obly irreversible sides is gyno .

propica help wont do him sh*t i wont take there word they didn't approve my post

 

[michel sapin]

antydhtor; dutasteride 2,5 mg inhibit 99 % of the 2-5 ar in the DP

 

[ahmed wolf]

I'm am going to start CDNUTS protocol after Christmas.

Lots of guys have been saying Sorghum is helping with their symptoms.

It's an African grain which is very androgenic that had been shown to significantly increase 5ar activity. As well as supplementing Creatine. I'm a lifter and used to use Creatine in the past. It significantly raises DHT levels up to 57%

It's just hard to weight training when you are brain fogged and feeling brain dead 24/7.

I thought this drug could cause sexual side effects. I was never aware the cognitive and mental damage it could do...

So healthy diet, weight training intensively to boost Testosterone, Sorghum to raise 5ar activity, and creatine for a dht increase.

If that gets me nowhere I will do CDNUTS protocol.

what are ur testosterone levels??

 

[MikeW]

damn man you start to sound crazy , you should go to propecia help .
man really , propecia leaves the sytem in two week .
the obly irreversible sides is gyno .

You are completely wrong. Stop giving false information.

 

[Ashkan63]

You are completely wrong. Stop giving false information.

You cant take finastride and you are basically praying that everybody else gets the same problem,this is a place for people who want to take finastride i think you need to change your forum,

 

[MikeW]

You cant take finastride and you are basically praying that everybody else gets the same problem,this is a place for people who want to take finastride i think you need to change your forum,

I'm warning other guys of the potential consequences that can happen with this drug.

 

[MikeW]

Do anything else to save your hair, Rogaine, topical solutions, RU58841, do not take the chance with Finasteride.

 

[Dench57]

@MikeW you're in the wrong forum

try solvepfs or propeciahelp

 

[g.i joey]

Don't feed a troll.

He should write his bullshits in his own topic, and not be doing propaganda against finasteride everywhere on this forum.

I felt bad for him originally but it seems more like an anti finasteride campaign rn more than anything.

 

[WMQ]

yes i think its real but i think it depends on how long u took it and what mental and physical state u were in when u took it

i understand but high dose of hormones should damege the receptors or make the receptors less sinsitve after stop using but that never happened
sure inhibiting 5ra is bad but it wont kill the receptors look at ppl taking finasteride for 15 years they should look like they are having chemo therpy on they are dying from unknown disease it there receptors stopped recognizing androgens

Finasteride doesn't kill receptors, it is exactly the opposite: it UPREGULATE androgen receptors while you're on the drug (common sense agrees with that). However, after quitting the drug cold turkey, your body undergoes a drastic rebound of androgen PLUS the already upregulated androgen receptors throughout your body, this might make the body believe that it needs to shut down androgen signaling, thereby causing androgen deficiency or androgen receptor downregulation. For some reason this never go away in the pfs sufferers.

Thi is what I read from several pfs forum threads. It's a plausible theory.

 

[sunchyme1]

Finasteride doesn't kill receptors, it is exactly the opposite: it UPREGULATE androgen receptors while you're on the drug (common sense agrees with that). However, after quitting the drug cold turkey, your body undergoes a drastic rebound of androgen PLUS the already upregulated androgen receptors throughout your body, this might make the body believe that it needs to shut down androgen signaling, thereby causing androgen deficiency or androgen receptor downregulation. For some reason this never go away in the pfs sufferers.

Thi is what I read from several pfs forum threads. It's a plausible theory.

so how would you suggest people fix this if it does happen to them? is it simply a case of living a very healthy lifestyle for a while as outlined in cdnuts protocol?

 

[WMQ]

But bodybuilders are injecting hormones and finasteride blocks 5ar which does more than just turn test into dht, it has a purpose in the brain. In the case of those slowly losing hair and those who stop losing hair all together, maybe thats a receptor problem. In the study they tested androgen action but not the receptor itself. Atleast thats what i got from it, i cant get the full study.

Did you clicked on the "full text” tag? I had no trouble viewing it. Maybe it's because I was accessing it from my university's network.

The paragraphs related to the receptor problem are:

Markers of peripheral androgen action
Hair growth, acne, sebum production, and testosterone-responsive markers, hematocrit and PSA, did not differ significantly among groups (Table 1). The expression levels of nuclear AR and β-catenin protein in the sebaceous glands and epidermis (Supplemental Figure 2), and other androgen-regulated mRNA transcripts in skin biopsies (Supplemental Figure 3) did not differ among groups.

AR and steroid SRD5A genes
Next-generation sequencing of the coding regions and splice sites of AR, SRD5A1, and SRD5A2 failed to reveal any significant variants with potentially deleterious changes (nonsense or frameshift variants) in any sample. Although a few missense variants of unknown impact on the protein were identified in some individuals, none were enriched in any cohort, and these were reported at similar frequencies as in general population databases such as 1000 Genomes (http://www.1000genomes.org/) and Exome Aggregation Consortium (http://exac.broadinstitute.org/). The lengths of the CAG repeats in exon 1 did not differ significantly among groups (mean [95% confidence limits]: group 1, 22.2 ± 2.2; group 2, 21.8 ± 2.5; and group 3, 21.0 ± 2.3; P = .236).

 

[WMQ]

I'm kind of disappointed that they narrowed themselves down to the sexual aspect of pfs.

What about the fatigue? The brain fog? The frickin messed up sleep pattern?

 

[WMQ]

so how would you suggest people fix this if it does happen to them? is it simply a case of living a very healthy lifestyle for a while as outlined in cdnuts protocol?

That would be the best way as banal as it sounds. I know people who try to restore themselves by going back to 5AR inhibitors (their reasoning is: since your body once shut down androgens when it was flooded with DHT, it might as well re upregulate androgen receptors when deprived of DHT again) and some people do experiencee improvement. I wouldn't suggest this for the obvious reason though.

 

[sunchyme1]

That would be the best way as banal as it sounds. I know people who try to restore themselves by going back to 5AR inhibitors (their reasoning is: since your body once shut down androgens when it was flooded with DHT, it might as well re upregulate androgen receptors when deprived of DHT again) and some people do experiencee improvement. I wouldn't suggest this for the obvious reason though.

you obviously know your stuff about this drug. would you say pfs is curable then? are you familiar with cdnuts and his recovery?

 

[sunchyme1]

I'm kind of disappointed that they narrowed themselves down to the sexual aspect of pfs.

What about the fatigue? The brain fog? The frickin messed up sleep pattern?

this is what is scary about this drug. I had all the stuff you mentioned above. I barely had any sexual sides. if anything I had a higher libido on it. but its all the other stuff. it messes with your general health. at least it did me. I think I had one of the worst reactions to it to be honest. I felt like I was being poisoned. but I also think I had one of the best reactions in terms of hair growth. after 6 months of heavy shedding, I regrow between 1-2 norwoods. which was impressive as f*** to me because it wasn't super recent loss. I guess I was just too sensitive to the stuff. great for my hair, bad for everything else.