MERRY XMAS SANTA HAS BROUGHT YOU A CURE
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Effects of watercress extract fraction on R-spondin 1-mediated growth of human hair
Objective: Hair loss and greying affect men and women of all ages, often causing psychosocial difficulties. Dickkopf-1 (DKK1), a major hair loss factor secreted from dermal papilla (DP) cells in response to the secretion of dihydrotestosterone (DHT), has been reported to induce and accelerate androgenetic alopecia (Androgenetic Alopecia). In addition, DKK1 acts as a potent suppressor of melanogenesis and is closely related to hair colour. R-spondin 1 (RSPO1) is a secretory agonist of Wnt signalling known to antagonize the effects of DKK1, including DKK1-mediated hair follicle suppression. In this study, we investigated the effect of watercress extract (WCE) on the secretion of RSPO1 and DKK1 from DP cells as well as its anti-hair loss effect in human hair follicles and patients.
Methods: The in vitro secretion of RSPO1 and DKK1 was measured by ELISA. Human hair follicles were collected from the scalp of a female donor and used for ex vivo organ culture to investigate the effects of WCE on human hair loss. Finally, a 6-month human clinical trial was conducted to examine the effect of WCE-containing lotion on hair growth in a male panel.
Results: WCE significantly upregulated RSPO1 secretion and suppressed DKK1 secretion in a dose-dependent manner, even in the presence of DHT. WCE-treated hair follicles elongated 1.6-fold compared with the control, and the level of RSPO1 production in DP as well as RSPO1 bound to the outer root sheath (ORS) increased. In the clinical trial, the hair lotion containing 2% WCE increased hair thickness and density to improve against hair loss symptoms.
Conclusion: WCE exhibited a strong anti-androgenic effect through its ability to suppress DKK1 secretion and antagonize DKK1 via RSPO1. These findings highlighted the potential use of WCE for the treatment of hair loss.
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Unfortunately there is a fee to access the study. I wonder if the new GB is raising money for lettuce extract ? )))
Since I don't condone secret societies, cliques and alliances and cults, I posted that study.
You can get watercress 10:1 extract on ebay very cheap for those who want to.
Effects of watercress extract fraction on R-spondin 1-mediated growth of human hair - PubMed
WCE exhibited a strong anti-androgenic effect through its ability to suppress DKK1 secretion and antagonize DKK1 via RSPO1. These findings highlighted the potential use of WCE for the treatment of hair loss.
pubmed.ncbi.nlm.nih.gov
This company in Japan has it available as CRESSON liquid B.
CRESSON Liquid B｜Cosmetic Ingredients｜ICHIMARU PHARCOS
ICHIMARU PHARCOS' CRESSON Liquid B cosmetic ingredient information. It is an extract obtained from the leaves and stem of Nasturtium officinalis R.Brown (Cruciferae). It is also known as Watercress.
www.ichimaru.co.jp
Japan conducts research that never really pans out in real time like the adenosine flop. Quality looking research but never went anywhere.
All in all, I think AT BEST it will(possibly) produce a minoxidil like effect.
The best explosive hair growth comes from systemic administration(and not if EVER topically) of whatever:
estrogens, minoxidil, calcium channel blockers, cyclosporine,benoxaprofen, spironolactone, , IL-17 inhibitors(vitamin d is one BTW), vitamin d study, etc.
I will have to read this post several times.
I like the posters thinking. I believe we shouldn’t concentrate so much on our natural hormones but find ways to override DHT destructive signaling.
We want most of our scalp hairs to be in Anagen & simply put DHT sensitivity puts a stranglehold on hair growth..,
Medical grade lasers/micro electric stimulation are 2 ways to overcome DHT. This maybe a third. If I can buy it I will..
Japanese Watercress Salad
I like the posters thinking. I believe we shouldn’t concentrate so much on our natural hormones but find ways to override DHT destructive signaling.
We want most of our scalp hairs to be in Anagen & simply put DHT sensitivity puts a stranglehold on hair growth..,
Medical grade lasers/micro electric stimulation are 2 ways to overcome DHT. This maybe a third. If I can buy it I will..
Japanese Watercress Salad
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