Mesotherapy And Dutasteride Sounds Promising

[Afro_Vacancy]

Works great, done once every three months, does not affect serum hormone levels:
http://www.hairlosscure2020.com/mesotherapy-with-dutasteride-to-treat-hair-loss/

Note to Histogen, this is what a convincing picture looks like:

 

[CharAblaze]

If no sides + maintenance sign me up. Minoxidil gives me similar results, but
it don!t stop the bald.

 

[Swoop]

I scanned the study quickly:

A prospective clinical study including patients diagnosed with Androgenetic Alopecia was designed. MD was performed with 1 mL of intradermal dutasteride 0.01% injections (dutasteride 0.01%, Mesotherapy Worldwide, Australia) through 6 months with a one-session treatment every three months; a total of three sessions.

This means that they injected the patients at the month 0, month 3 and month 6, right...

Assessment of the response was done 9 months after the first injection by three dermatologists who evaluated the degree of improvement as follows: −1 = worsening, 0 = no change, 1 = improvement. To evaluate the safety of the therapy, a strict surveillance for adverse effects was done. In addition, laboratory investigations (total and free testosterone, 5-alpha-dihydritestosterone, and 3-alpha-androstanediol glucuronide) were performed before and after treatment to analyse if the treatment produced any systemic hormonal modification. Statistical analysis with the Wilcoxon signed-rank test was performed to detect significance between laboratory results.

However the assessment was done 9 months after. There is no clear mention on when they did the laboratory investigations, only the mention of "performed before and after treatment".

That is not concrete. If the laboratory investigations are done at 9 months it is totally expected there would be no systemic hormonal modification.

But honestly even if the laboratory investigations were done at 6 months it doesn't exactly mean that there was no systemic hormonal modification over the course of these treatments. It just means that at that time point there was no (significant) hormonal modification in comparison with before the treatment.

To illustrate this it might look like this:

You inject the patient on day 1, you measure blood serum levels after the injections on day 1 or day 2. You see no hormonal modifications.

Now you wait another half week and you measure again, suddenly you see hormonal medications.

Since this is injected instead of orally ingested it is only expected that the concentration of dutasteride in serum takes longer and thus it takes longer before serum levels are affected.

Bottom line is, is that this study is severely limited and the study method is quite poor. So how does one even look further?

 

[Janks16]

I was on Dutasteride for about 2 years. I initially got shortness of breath that happened only occasionally, and I didn't know that the cause was from Dutas. Over time the side effect became frequent and I checked myself in hospital because I thought I was having a heart attack. I had developed an irregular heartbeat. Once I got off it, it took about a month to return to normal and I've been fine ever since. This was about 7 years ago. BTW, Dutas did nothing to grow any hair.

 

[vernon]

before-after photos mean absolutely nothing. this could just be longer hair, toppik and lighting (even though it looks better than average photos of that kind)


as long as people are falling for it so easily, there will be scammy claims .

no actual people (in increasing numbers) confirming it works = no noteworthy product

 

[kiwipilu]

before-after photos mean absolutely nothing. this could just be longer hair, toppik and lighting (even though it looks better than average photos of that kind)


as long as people are falling for it so easily, there will be scammy claims .

no actual people (in increasing numbers) confirming it works = no noteworthy product

you are right the conditions are not the same but the photos are quite transparente nonetheless. when you have such a thinning area , I don't think the lightning can do the trick. I just notice on the first picture you see the shiny scalp and on the other one you don't . In addition there is no combover. I think it's quite safe to say there is some sort of hair thickening BUT that's only pictures and like you said numbers are the ones that don't lie.But with such drug you just expect thickening maintenance not really regrowth I guess.
Btw not sure about the 1treatment/3month though

 

[jamesbooker1975]

This stupid :
1) We know dutasteride works
2) We know dutasteride give side effects
3) Mesotherapy is inject into your scalp, if topical go systemic, guess what happen when injecting ?
4)Dutasteride have a 5 weeks half life
5) They do not checked the systemic DHT

 

[Swoop]

What is it with these studies that have fewer than 10 cohorts? Who thinks that's enough of a sample? And using photography as data? Where are the hair counts? Weird.

Good question. Might be a form of bias/marketing? But it is quite ridiculous, yes. There is good research and bad research I guess.

 

[folfoxorack]

So nobody can dislikes Swoop's comments ... Just because he works for a transplant company - and Kane ?
I'm curious O_O

 

[Mage]

So nobody can dislikes Swoop's comments ... Just because he works for a transplant company - and Kane ?
I'm curious O_O

When a story doesn't make sense, follow the money.