Minoxidil/finasteride stopped being effective. Any advice?

jamesbooker1975

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Yes it enhances sulfotransferase enzymes but does it actually make them respond?
YES !!!!!!!!!READ THE PAPER !!!!!!!!!!!!!!! Jesus, you should be worry more about what is under your scalp what what it is over . How the hell you can be such an ignorant ?! you are a waste of time .
 

losingbattle88

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no it doesnt because they didnt actually use minoxidil in the study
Sulfor enzyme is created in the liver when u take oral minoxidill. I took it for 5 months hair got thinner not thicker, Body hair like my hands got hairier, And tretionin cream is expensive as sh*t anyways.
 

Nebula74

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Sulfor enzyme is created in the liver when u take oral minoxidill. I took it for 5 months hair got thinner not thicker, Body hair like my hands got hairier, And tretionin cream is expensive as sh*t anyways.
yeah the enzyme metabolises it in the liver of most people, still then some very unlucky people they don't have the enzyme. So I am going to see if I can get topical diazoxide which doesn't need the enzyme
 

jamesbooker1975

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no it doesnt because they didnt actually use minoxidil in the study
no it doesnt because they didnt actually use minoxidil in the study
Hahahajajajajajaja. “43 subject Not minoxidil responder where convert it into minoxidil responder after adding tretinoin “ Dude, seriously , you have worst problema than your hair, you can’t even read .
 

Nebula74

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Hahahajajajajajaja. “43 subject Not minoxidil responder where convert it into minoxidil responder after adding tretinoin “ Dude, seriously , you have worst problema than your hair, you can’t even read .
No it doesn't they just set an arbitrary number of sulfotransferase levels and determined that to be a Minoxidil response. The subjects didn't even use Minoxidil in the study, have u even read the full study? All they did was put tretinoin on peoples scalps for 5 days. Some people on tretinoin went down! Unless they do a study on it with concurrent Minoxidil use on people who failed to respond to Minoxidil in the past, then this study means nothing
 

jamesbooker1975

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No it doesn't they just set an arbitrary number of sulfotransferase levels and determined that to be a Minoxidil response. The subjects didn't even use Minoxidil in the study, have u even read the full study? All they did was put tretinoin on peoples scalps for 5 days. Some people on tretinoin went down! Unless they do a study on it with concurrent Minoxidil use on people who failed to respond to Minoxidil in the past, then this study means nothing

e. Of clinical significance, in our cohort, 43% of subjects initially predicted to be nonresponders to minoxidil were converted to responders following 5 days of topical tretinoin application. To the best of our knowledge, this is the first study to elucidate the interaction mechanism between topical minoxidil and retinoids and thus provides a pathway for the development of future androgenetic alopecia treatments.

Dude, what the hell are you talking about !?! The did use minoxidil .
 

Nebula74

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e. Of clinical significance, in our cohort, 43% of subjects initially predicted to be nonresponders to minoxidil were converted to responders following 5 days of topical tretinoin application. To the best of our knowledge, this is the first study to elucidate the interaction mechanism between topical minoxidil and retinoids and thus provides a pathway for the development of future androgenetic alopecia treatments.

Dude, what the hell are you talking about !?! The did use minoxidil .
No they didn't they just used tretinoin and measured sulfotransferase, if you'd read the whole study like I have then you'd know that, but clearly you are too braindead and are just promoting a study that you haven't even read
 
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jamesbooker1975

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No they didn't they just used tretinoin and measured sulfotransferase, if you'd read the whole study like I have then you'd know that, but clearly you are too braindead and are just promoting a study that you haven't even read
Jesus Christ DUDE ! they used minoxidil ! READ THE DAMN STUDY !!!!!
AND Even, lets keep your argument, they show it activate sulfotransferase levels in vivo ! All the top doctos used ! It is the " why " Xandrox was a success !
Dude, really, you should get a life.
 

Nebula74

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Jesus Christ DUDE ! they used minoxidil ! READ THE DAMN STUDY !!!!!
AND Even, lets keep your argument, they show it activate sulfotransferase levels in vivo ! All the top doctos used ! It is the " why " Xandrox was a success !
Dude, really, you should get a life.
no they didnt you idiot, you are just shilling! all they did was use tretinoin for 5 days, and like i said, not even with minoxidil! showing this study like it means something is decieving! u r too dumb to argue with and keep insulting me. Xandrox is overrated and I guarantee that no one who doesn't respond to Minoxidil will respond to tretinoin + Minoxidil. And you still can't prove it.
 

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  • Dermatologic Therapy - 2019 - Sharma - Tretinoin enhances minoxidil response in androgenetic a...pdf
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jamesbooker1975

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no they didnt you idiot, you are just shilling! all they did was use tretinoin for 5 days, and like i said, not even with minoxidil! showing this study like it means something is decieving! u r too dumb to argue with and keep insulting me. Xandrox is overrated and I guarantee that no one who doesn't respond to Minoxidil will respond to tretinoin + Minoxidil. And you still can't prove it.
Dude, you are bald as a dick and want to reverse to a norwood 0, and since you cant't do that, " nothing works ".
Get a life .
"You can't still prove it " What next ? Aspiring don't prevent strokes ? lol . Dude, really get a life.
It is use it by top doctos since the 80s. It was in the original formula of the famous Dr. Lee. There are, at least, 12 studies on pubmed combine it with minoxidil. This study SHOW that it actuall increase the sulphatase activitie and it was done IN HUMANS !!!!!!!!!!
Dude, really, get a life, you are and you will be bald as a rock .
 

losingbattle88

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So jamesbooker is basically saying minoxidil and tret is the cure for male pattern baldness? Nothing else beats it. Lol
 

DominoEffect

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losingbattle88

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Yep, someone needs to take him back to his nursing home, he has bigger issues than hair loss
I took oral minoxidil super high dose for 5 months or more and no effect on hair. The sulfor sh*t is created in the liver. I just got harier on Body not scalp.
 
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