More info on the vehicle in the topical melatonin study

[mvpsoft]

I've been taking melatonin orally for years, and it has done nothing for my hair loss.

Ummm....to be perfectly fair, how do you really KNOW that it's done nothing for your hair loss? Isn't that a little like saying, "I've been taking finasteride for the last 10 years, and it's done nothing for my hair. It's exactly the same as it was 10 years ago."??

Well, let's put it this way, I've been losing my hair gradually for maybe 20 years, and I've been taking melatonin for about 10 years. My rate of hair loss has stayed pretty much constant over those 20 years.

 

[Bismarck]

It has a depot effect in the stratum corneum and is slowly going into the bloodstream.

I don't know if it really has much of a depot effect (where did you hear that, Bis?), but it was certainly absorbed to some extent from topical application in that study! Here's the full paragraph about that:

"Melatonin was resorbed by scalp skin and led to plasma levels of between 35 and 50 pg/mL, which were significantly higher than in the placebo group with constant levels of 5-10 pg/mL. There was a high inter- and intraindividual variability of melatonin levels in both the melatonin and the placebo group, although melatonin levels in the treatment group did not exceed the physiological night peak of 250 pg/mL."

It's fairly obvious now why they had their subjects use the melatonin topical in the evening! :wink:

Bryan

Armando posted the study: These findings indicate that melatonin might accumulate in the stratum corneum with prolonged release into the blood system from this depot.

If I remember correctly, the Fischer study says that day the melatonin serum level at daytime were never higher then the night peak.

bis

 

[Armando Jose]

In this study the investigators used a lot of Melatonin:
Then 3 of the participants were treated once topically on their scalp with 20 mg melatonin dissolved in 70% ethanol, while the other 3 individuals received 100 mg. The application was performed at 9.00 a.m., and blood samples were collected repeatedly for a total of 8 h. Physiologic daytime melatonin levels in the 6 individuals were 16.8 +/- 10.0 pg/ml. The 3 individuals treated with 20 mg melatonin displayed peak serum levels of 762, 918 and 3,440 pg/ml, respectively, those treated with 100 mg melatonin showed peak levels of 1,136, 3,360 and 4,230 pg/ml lasting throughout the entire observation period of 8 h.

In the Fischer study used a lot less melatonin.
Armando

 

[Christoph]

Yes ,I would like to know if it will work on males .Melatonin? Isn't that crap to help sleep .

 

[Bismarck]

Yes ,I would like to know if it will work on males .Melatonin? Isn't that crap to help sleep .

Yes it is. Also produced in your brain.

 

[pilogenic101]

Is there any retation between melatonin and melanin, the hair pigment? Spray on melatonin and get rid of the gray? Probably not. :lol: &&&& I suspect that some early graying of the hair may be related to a scalp or systemic infection, like a fungus.

 

[mvpsoft]

Is there any retation between melatonin and melanin, the hair pigment?

No, melanin is skin pigment.