New Hair Growth Mechanism Discovered

[S Foote.]

Good point because, yes, according to a British study, type II diabetes was reversed in 12 of 30 patients who lost weight through diet and, more importantly, lost fat in their pancreas, about one gram of pancreatic fat loss apparently enough to relieve stress on the organ. Other studies have shown that insulin resistance in muscle cells (and insulin sensitivity in fat cells) can be reversed with diet and exercise. Type 2 doesn't always have to lead to the more serious type I condition. Is it possible to reverse baldness through diet and exercise similarly? Or as S. Foote says possibly by increasing blood flow and reducing the hydraulic effect with lymph drainage in and around the scalp?

This study of botox injections into the scalps of Balding men revealed similar results to Merck's propecia. I tbink iy suggests that increasing blood flow in the scalp is just as effective as blocking DHT and tends to support S. Foote's theory for a hostile environment in general. Why does DHT have the exact opposite effect on HF everywhere else on the body beginning at puberty?

http://journals.lww.com/plasreconsu..._Botulinum.79.aspx?WT.mc_id=HPxADx20100319xMP<br%20/>

I think DHT is certainly the triggering factor, but not directly within the follicle itself. I suggest there is far more evidence for and logic behind the significant action of DHT upon hair growth as being indirect. I think the action of DHT of increasing body and beard hair growth is the norm, while hair loss is the opposite effect that relies on other factors within the individual, like higher local blood pressure. I discuss this in my article.

I think DHT induced lymphedema in male pattern baldness, gives order and logic to all the recognised data.

The increasing tissue fluid pressure restricts the enlargement of the follicles through the normal pressure based spatial growth controls. We know this must trigger an internal growth restricting chemistry, and the involvement of known growth restricting factors affecting Wnt's etc makes perfect sense here.

Tissue fluid is the raw material for any glandular secretion, and increased tissue fluid pressures and levels explain the increased sweat and sebum secretion in the bald scalp.

The increased fluid pressures in tissues caused by lymphedema, is recognised as creating increased immune reactions and mast cell activation (PGD2) also fibrosis.

The factors that increase hair growth in male pattern baldness, have the common factor of also reducing tissue fluid levels. Anti-inflammatory drugs speak for themselves here. The biggest complaint about Minoxidil is bad skin and wrinkles, shrunken skin is wrinkled skin. Low level lasers are also used to reduce fluid pressures in lymphedema, as is massage. Latanoprost was actually developed to reduce fluid pressure in the eye.

Parsimony in science is important, and it is only an initial rise in scalp fluid pressure, that can explain all the recognised factors in male pattern baldness by one action of DHT.

 

[Trichosan]

...I think DHT induced lymphedema in male pattern baldness, gives order and logic to all the recognised data.

The increasing tissue fluid pressure restricts the enlargement of the follicles through the normal pressure based spatial growth controls. We know this must trigger an internal growth restricting chemistry, and the involvement of known growth restricting factors affecting Wnt's etc makes perfect sense here....

The increased fluid pressures in tissues caused by lymphedema, is recognised as creating increased immune reactions and mast cell activation (PGD2) also fibrosis...

Interesting. I'd like to look at the medical literature on your correlation with lymphadema. References?

 

[S Foote.]

Interesting. I'd like to look at the medical literature on your correlation with lymphadema. References?

In my article here.

https://www.academia.edu/17570665/A...nt_Hair_Research_and_an_Overlooked_Connection.

 

[Balding curse]

In my article here.

https://www.academia.edu/17570665/A...nt_Hair_Research_and_an_Overlooked_Connection.

I was trying to read your article but the page is moving up on it's own when it's loading, you should post this on a new thread it's an interesting article.

 

[S Foote.]

I was trying to read your article but the page is moving up on it's own when it's loading, you should post this on a new thread it's an interesting article.

I will try to add it here as an attachment if it works!

 

[S Foote.]

I would just like to say something about the current obsession in biology with molecullar studies, and how this relates to hair research.

The molecullar studies alone, cannot predict in-vivo systems interactions. To make an analogy, if you wanted to understand an issue with your car, dissecting the factory production line that built it, is not going to tell you much. You will find associations where features of certain cars, can be linked to certain processes on the production line. Its the same in biology.

Sooner or later you have to try to fit the parts together in the system. Sometimes you don't even need to know what's happening at the molecullar level, to understand a process at the functional level. I suggest this is the case with changes in hair growth. Forget male pattern baldness for a while and consider hair follicles in evolution.

In terms of evolutionary function, hair growth needs to be adjustable. In early mammals hair growth needed to respond to environmental temperature changes, and be shed in response to tissue damage to reduce risk of infection. Physically the structure of the hair follicle and the hair cycle, are very well adapted to be adjusted by slight changes in the surrounding dermal fluid pressure, through recognised spatial growth controls. I discuss the evolutionary advantages of this dermal interaction in my article.

What this means in terms of modern Human hair growth is that "any" factor that changes the dermal fluid pressure, will change the local hair growth. It should be very clear to people who use Finasteride, that DHT has significant effects on changing tissue fluid pressures. Finasteride was designed to shrink the prostate gland, that DHT causes to "swell". The other effect of Finasteride in the "system", is to increase the swelling of breast tissue in men. It is the same opposite effect of DHT, that we are aware of in hair growth. Its all about fluid dynamics and opposite effects in systems.

The bad news is this explains the failure of past efforts to develop cell based treatments for male pattern baldness. It also predicts the failure of the current lines of cell based research. Any efforts to grow new large follicles by implanting cells, is going to be prevented by the same high dermal pressure that miniaturised the original follicles.

The good news is that scientists in the position to do so (I am not), could quite easily develop ways to reduce this dermal pressure. That will be the only real way forward here, and should be cheaper, safer and have better results than any of the current research can offer.

 

[Captain Rex]

The good news is that scientists in the position to do so (I am not), could quite easily develop ways to reduce this dermal pressure. That will be the only real way forward here, and should be cheaper, safer and have better results than any of the current research can offer.

Tsuji was also saying about the same thing " a perfect environment which generates hair follicle" - maybe this thing about pressure correction has already been used in his method.

 

[Balding curse]

What this means in terms of modern Human hair growth is that "any" factor that changes the dermal fluid pressure, will change the local hair growth. It should be very clear to people who use Finasteride, that DHT has significant effects on changing tissue fluid pressures. Finasteride was designed to shrink the prostate gland, that DHT causes to "swell". The other effect of Finasteride in the "system", is to increase the swelling of breast tissue in men. It is the same opposite effect of DHT, that we are aware of in hair growth. Its all about fluid dynamics and opposite effects in systems.

Does that have something to do with increasing sebum with cold or hot weather, I have noticed that my scalp become very oily when I stay in a cold place for a while.

 

[S Foote.]

Does that have something to do with increasing sebum with cold or hot weather, I have noticed that my scalp become very oily when I stay in a cold place for a while.

Yes I think it is all connected.

 

[Armando Jose]

Sebum as a "liquid" must have a role in dermal fluid pressure, more when it can change its viscosity.....