New Prostaglandins (PGD2 and PGI2) study

[StayPositive]

The paper says this :

"we found that PTGDS is overexpressed in Androgenetic Alopecia and PTGES is overexpressed in the firsts stages of Androgenetic Alopecia. We did not find differences in PTGDR2 in affected and unaffected individuals. Perhaps, the roll of prostaglandins differs from first to late stages, resulting in different clinical response to therapy with drugs that target PTGDR2, PTGDS and PTGES depending on the stage of Androgenetic Alopecia. "

Wow i am so lost

 

[ElToso]

The paper says this :

"we found that PTGDS is overexpressed in Androgenetic Alopecia and PTGES is overexpressed in the firsts stages of Androgenetic Alopecia. We did not find differences in PTGDR2 in affected and unaffected individuals. Perhaps, the roll of prostaglandins differs from first to late stages, resulting in different clinical response to therapy with drugs that target PTGDR2, PTGDS and PTGES depending on the stage of Androgenetic Alopecia. "

Wow i am so lost

me too

 

[StayPositive]

me too

If that's the case, COX 1 / COX 2 inhibitors seems more promising than PGD2 antagonist because COX inhibitors block the cascade before PTGDS is formed

You just have to add pge2 analogs because obviously cox inhibits pge2 too. Ricinoleic acid (from castor oil) seems perfect for that, and it is also a PTGDS inhibitors on its own.

So the cure could be COX1 / COX 2 inhibitors + PGE2 analogs

Aspirin + oral castor oil combo seems extremely promising

 

[balda]

We still don't know if pgd2 is the cause of male pattern baldness or just a byproduct of it

it contributes to the process, maybe it's a critical or near to part of it:
"As different prostaglandins have opposing biological effects, PGD2 MAY MEDIATE testosterone INHIBITION OF WNT signaling IN Androgenetic Alopecia. Future studies are needed to test this hypothesis."
and a little bit more:
"It is interesting to speculate that AR roles in other physiological processes may be tied to its role as a β-catenin/Wnt inhibitor."

Bad Hair Day: Testosterone and Wnts - PMC

Androgens have an important role in normal skin physiology, as well as in the pathogenesis of many skin conditions, such as acne vulgaris, hirsutism, and androgenic alopecia. Kretzchumar et al. (2015) investigate the relationship between androgen ...

www.ncbi.nlm.nih.gov

As i heard, Seti users tend to add PGE2 to their protocols:
"Seti is only for a maintenance and a prerequisite for PGE2 to work."

One more thing is PGF2. Check Latanaprost/Bimatoprost. Girls use it for eyebrows.

 

[StayPositive]

it contributes to the process, maybe it's a critical or near to part of it:
"As different prostaglandins have opposing biological effects, PGD2 MAY MEDIATE testosterone INHIBITION OF WNT signaling IN Androgenetic Alopecia. Future studies are needed to test this hypothesis."
and a little bit more:
"It is interesting to speculate that AR roles in other physiological processes may be tied to its role as a β-catenin/Wnt inhibitor."

Bad Hair Day: Testosterone and Wnts - PMC

Androgens have an important role in normal skin physiology, as well as in the pathogenesis of many skin conditions, such as acne vulgaris, hirsutism, and androgenic alopecia. Kretzchumar et al. (2015) investigate the relationship between androgen ...

www.ncbi.nlm.nih.gov

As i heard, Seti users tend to add PGE2 to their protocols:
"Seti is only for a maintenance and a prerequisite for PGE2 to work."

One more thing is PGF2. Check Latanaprost/Bimatoprost. Girls use it for eyebrows.

I think pgd2 is extremely critical. I think it's the most important to block. I think you can stop male pattern baldness without taking anti androgen if you block correctly pgd2 and keep pge2 normal or high

I think pgd2 pathway is very underestimate because Seti was a complete failure.

Regarding pgf2, everything that increases or upregulates pge2 activity increases pgf2 activity too

You can see why here:

 

[balda]

If you have a question about what to do first - to raise PGE2 or to lower PGD2? Check this thread:

https://www.gourmetstylewellness.com/interact/threads/allergen-seti-trial-results-have-been-posted.121757/page-3#post-1787843

"

Silver lining: You may be able to get SwissTemples and Westonci-tier results by skipping PGD2 inhibition. All aboard the PGE2 and needling train.

I strongly believe this. I got almost almost all of my results from PGE2+dermarolling
"

 

[StayPositive]

If you have a question about what to do first - to raise PGE2 or to lower PGD2? Check this thread:

https://www.gourmetstylewellness.com/interact/threads/allergen-seti-trial-results-have-been-posted.121757/page-3#post-1787843

"

I strongly believe this. I got almost almost all of my results from PGE2+dermarolling
"

Yes pge2+Dermaroller is the best the regrowth but i don't believe it will bring long term maintenance since it does not address pgd2

For me i was on 10mg oral minoxidil(only minoxidil treatment) for 1 year and i did absolutely nothing for my hair. Growths factors agonists are not enough, you have to tank pgd2 which causes miniaturization over time

 

[Charger]

Wish there was an affordable PGD2 inhibitor that doesn't touch anything else except PGD2.

 

[StayPositive]

Wish there was an affordable PGD2 inhibitor that doesn't touch anything else except PGD2.

In theory COX inhibitors + PGE2 analogs should work, no?

I know COX inhibitors greatly reduce PGE2, but If you take PGE2 analogs at the same time, what is the problem?

 

[ElToso]

Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44 - PubMed

Prostaglandins (PGs) are key inflammatory mediators involved in wound healing and regulating hair growth; however, their role in skin regeneration after injury is unknown. Using wound-induced hair follicle neogenesis (WIHN) as a marker of skin regeneration, we hypothesized that PGD2 decreases...

pubmed.ncbi.nlm.nih.gov

a PGD2 receptor antagonist in conjunction with microneedling might be a good combo

 

[Charger]

In theory COX inhibitors + PGE2 analogs should work, no?

I know COX inhibitors greatly reduce PGE2, but If you take PGE2 analogs at the same time, what is the problem?

Specific inhibition of PGD2 would be better, imo. I don't know whether or not the COX pathway is necessary for PGE2 analogs to do their job, maybe someone here who knows more than me could enlighten us.

But really, I'd imagine any PGD2 Inhibitor + Almost any growth agonist would be worth experimenting with. Whether it's PGE2, PGF2a, Minoxidil, Needling, etc.

 

[StayPositive]

Specific inhibition of PGD2 would be better, imo. I don't know whether or not the COX pathway is necessary for PGE2 analogs to do their job, maybe someone here who knows more than me could enlighten us.

But really, I'd imagine any PGD2 Inhibitor + Almost any growth agonist would be worth experimenting with. Whether it's PGE2, PGF2a, Minoxidil, Needling, etc.

We know the COX pathway is not necessary for proper pge2 analogs stimulation

In fact, in this study they find that Diclofenac+ Minoxidil is more effective in treatment of male pattern baldness than Minoxidil alone:

Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study - PMC

The variable success of topical minoxidil in the treatment of androgenic alopecia has led to the hypothesis that other pathways could mediate this form of hair loss, including infection and/or microinflammation of the hair follicles. In this study, ...

www.ncbi.nlm.nih.gov

 

[it2wi]

If that's the case, COX 1 / COX 2 inhibitors seems more promising than PGD2 antagonist because COX inhibitors block the cascade before PTGDS is formed

You just have to add pge2 analogs because obviously cox inhibits pge2 too. Ricinoleic acid (from castor oil) seems perfect for that, and it is also a PTGDS inhibitors on its own.

So the cure could be COX1 / COX 2 inhibitors + PGE2 analogs

Aspirin + oral castor oil combo seems extremely promising

This is correct, from what I know.

Ideally you just target PGD2 and don't block COX because you want the PGE2 production from COX, but if no choice then blocking COX and supplementing with topical PGE2 would be a workaround.

Related note, I seem to be having decent effects from topical Cetirizine in helping to reduce shed / tackle PGD2. I've been using for 5 days now, 2x a day at 1% potency. It's not as good as the topical Seti results I had in the past, but it seems to be a net positive effect for PGD2. Actually surprised.

 

[LouisSarkozy]

This is correct, from what I know.

Ideally you just target PGD2 and don't block COX because you want the PGE2 production from COX, but if no choice then blocking COX and supplementing with topical PGE2 would be a workaround.

Related note, I seem to be having decent effects from topical Cetirizine in helping to reduce shed / tackle PGD2. I've been using for 5 days now, 2x a day at 1% potency. It's not as good as the topical Seti results I had in the past, but it seems to be a net positive effect for PGD2. Actually surprised.

nice so could maybe used as a weaker alternative to seti maybe? ( for those unwilling to buy from kane or chinese labs)

 

[it2wi]

nice so could maybe used as a weaker alternative to seti maybe? ( for those unwilling to buy from kane or chinese labs)

Yeah I think it's definitely worth a shot, since it's so cheap to get generic Ceterizine pills. And we know at 1% (10mg) topically, it's safe since 10mg oral is considered a safe daily dose for adults.
Still a bit early in my case to know definitively if it's working or not, I'm going to give it 2 months, but should see some vellus hairs come in with maintained reduced shed over the next two weeks if it's having an effect