Newly Discovered Factor in Androgenetic Alopecia. The Cure is Near?

[young trunks]

Re: A recently discovered new factor in AA, the cure is near

further analysis of the mechanism of action of ramatroban has now been performed. PGD2-stimulated human eosinophil migration was shown to be mediated exclusively through activation of CRTH2, and surprisingly, these effects were completely inhibited by ramatroban!!!!!! I guess ramatroban + PGF2alpha (bimatropost) SHOULD mean FULL REGROWTH! (its what I hope!)I truely believe in it

http://jpet.aspetjournals.org/content/305/1/347.long

So what should I use?? I can't wait any longer...

I did lots of research all day and have come up with a possible regimen.
Omega 3 blocks prostaglandins d2. Take it and hair vitamins...(but I had thyroid test done and everything fine). Back to regimen.

Take Fish Oil/Cod liver oil. Take hair vitamins if you think ur lacking...and take Cayenne Pepper/Fruit supplement to increase blood flow in body. This will get vitamins to the head/scalp. FAST!!

Exercise run for a bit too it really helps circulation and cayenne really does too...from experience.

Topically..I'm still trying to figure out but I think Emu oil or Fish Oil used as a deep condtioner will eliminate the pdg2. Or whatever you all suggest as the inhibitor. And use a shampoo that is none sls.

I think that Fish Oil topically is the best pdg2 without side effects bc it is hormone stuff that the body uses to fight it off anyway. That would mean the same for head topically right??

what do you all think?

 

[LooseItAll]

Re: A recently discovered new factor in AA, the cure is near

further analysis of the mechanism of action of ramatroban has now been performed. PGD2-stimulated human eosinophil migration was shown to be mediated exclusively through activation of CRTH2, and surprisingly, these effects were completely inhibited by ramatroban!!!!!! I guess ramatroban + PGF2alpha (bimatropost) SHOULD mean FULL REGROWTH! (its what I hope!)I truely believe in it

http://jpet.aspetjournals.org/content/305/1/347.long

Yes. Unfortunately Ramatroban is only available from china and is quite pricey. There is no way to get your hands on japanese Baynas. Same goes for Seratrodast.

 

[TravisB]

Re: A recently discovered new factor in AA, the cure is near

I don't like the title of this topic. The cure is NOWHERE near.

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

Nonsense!

The cure is already there. We just need to grab it!


ramatroban is 103 usd/G. And possible for 50-70usd/G if we make a signup list. Let say 10 people are going to order ramatroban, Then I or someone else contacts the seller for discount. Very simple!

I guess you never used cb-03-01 (390usd/gram)... so ramatroban is cheap compared to that.


And in the future withing 4 months we will have the CRTH2 antagonist OC000459 on our scalps!!

 

[LooseItAll]

Re: A recently discovered new factor in AA, the cure is near

103/g from an unverified supplier...

Plus we need to be careful. The study did not conduct that PGD2 alone is causing hair miniaturisation but rather excess levels of it. PGD2 is still present in smaller amounts in non balding areas and may be actually benefitial

 

[TravisB]

Re: A recently discovered new factor in AA, the cure is near

The study did not conduct that PGD2 alone is causing hair miniaturisation but rather excess levels of it.

This.

And also, 103 dollars for a gram? For how long would the gram last? Could we use it topically? What would be the vehicle then? I'm skeptical that it will work, but nevertheless I would like to see someone try it

EDIT:

OK, from here: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1193

Baynas tablets are 50 mg, and the dosage is 75 mg twice daily. So it's 150 mg daily. So a gram would last us 1000/150 = about a week. It would be 400$ month, so it's f*****g expensive if you ask me!

Also look at the common side effects:

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: abdominal pain, headache, dull headache, sleepiness, rash, itch, nausea, diarrhea, palpitation, gastric discomfort, uric blood, gum bleeding, nasal bleeding, subcutaneous bleeding, purpura, prolonged menstruation, etc.

 

[LooseItAll]

Re: A recently discovered new factor in AA, the cure is near

The study did not conduct that PGD2 alone is causing hair miniaturisation but rather excess levels of it.

This.

And also, 103 dollars for a gram? For how long would the gram last? Could we use it topically? What would be the vehicle then? I'm skeptical that it will work, but nevertheless I would like to see someone try it

EDIT:

OK, from here: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1193

Baynas tablets are 50 mg, and the dosage is 75 mg twice daily. So it's 150 mg daily. So a gram would last us 1000/150 = about a week. It would be 400$ month, so it's f****ing expensive if you ask me!

Also look at the common side effects:

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: abdominal pain, headache, dull headache, sleepiness, rash, itch, nausea, diarrhea, palpitation, gastric discomfort, uric blood, gum bleeding, nasal bleeding, subcutaneous bleeding, purpura, prolonged menstruation, etc.

Well not exactly. 150 mg is the oral dose so it is a dose for the whole body. A topical application of 15 mg would probavbly be more than enough.

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

I going to start with 0.5%

Thats 5mg/ml.

Its okay to be skeptikal. But I'm pretty convinced thst pgd2 is
The bad *** that inhibits out hairgrowth. After reading much studies. Pgd2 is 12 times more present in the balding area compared with non balding people.

 

[TravisB]

Re: A recently discovered new factor in AA, the cure is near

But have you thought about what will dissolve the tablet?

 

[waynakyo]

Re: A recently discovered new factor in AA, the cure is near

For those who are suggesting you can eat/run something available in nature to cure baldness:

I just made this from back of envelope calculations (lazy Sunday):

It plots the number of population since 10000BC until today, and assumes that every year one in 20 thousand people trying rubbing something new one their hair. Is this too much or is it too conservative ? I think it is definitely quite conservative for nowadays. Further, in terms of eating habits, people ate all kinda of stuff, and I am pretty sure that more than 1/20 000 tried something new every year... but to be on the conservative side, given these assumptions, you have until today: 60 million hair loss experiments. This is cumulative (while the population line is not, also take note of the 2 axes).

this is why I never try to rub something that is bioavailable in nature, as people have definitely tried that. But you cannot say the same for RU,finasteride, and other stuff made in the labs...
hope this will deter further waste of time...

I think the Ramotroban on the other hand is very promising.. attacking 2 mechanisms is better than one.. so please keep me posted

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

anyone want to look into Nettle Root Extract?

....Nettle root also has anti-inflammatory effects by reducing leukotriene and prostaglandin synthesis.....

:dunno: :dunno: :dunno:

 

[tomcatt]

Re: A recently discovered new factor in AA, the cure is near

9HODE extract from Glechoma hederacea (a plant) is an antagonist of PGD2 :

http://www.ncbi.nlm.nih.gov/pubmed/3691528

They don't talk about PGE2 or PGF2 .

 

[Swopo]

Re: A recently discovered new factor in AA, the cure is near

9HODE extract from Glechoma hederacea (a plant) is an antagonist of PGD2 :

http://www.ncbi.nlm.nih.gov/pubmed/3691528

They don't talk about PGE2 or PGF2 .

should we take this internaly or topicaly?

Can you check out Calendula also? Maybe it could be used instead of minoxidil.
It cures acne and everything on skin and increases blood flow. Wounds heal quicker also if you rub the flower or the oil on it..

Regarding herbal medicine, rosemary should help with hairloss.

This would be amazing. A regimen with those 4 plants would cost me just the cost of the alcohol.

 

[LooseItAll]

Re: A recently discovered new factor in AA, the cure is near

http://ajpendo.physiology.org/content/2 ... 8.full.pdf

Here is the link to the study. DHT via androgen receptor icreases COX-2, but PGE2 levels are not significantly icreased(while PGD2 levels are probably increased). As oposed to "legit" inflammation where COX-2 derived PGE2 increases.

I am even more keen on trying topical celecoxib now.

 

[Loomis]

Re: A recently discovered new factor in AA, the cure is near

Boldy, are you going to do any home experiments?

 

[young trunks]

Re: A recently discovered new factor in AA, the cure is near

After I finish this regimen in a lil less than a week in half I'm going to try this other regimen I just thought about.

Nizoral/ketoconazole combined Emu oil combined. If I'm correct the Emu Oil will block the PGD2 bc it has Omega 3 in it. And it absorbs fast. The nizoral/keto will deal with the dht.

Then I will continue to take Omega 3 and cayenne pepper (to make sure the stuff gets to the scalp internally)

I think this may work for us all...bc it's attacking everything..I'll let everybody know... what yal think??

 

[young trunks]

Re: A recently discovered new factor in AA, the cure is near

Nevermind I can't use keto too many sides...gotta make new plan up

 

[Loomis]

Re: A recently discovered new factor in AA, the cure is near

Emu oil won't help, it's pointless imo. If people are going to try and block the right receptor, it's going to take a topical made from a clinically tested drug to achieve the right result. Boldy seems to be going in the right direction.

 

[LooseItAll]

Re: A recently discovered new factor in AA, the cure is near

1.Pls see the quotation below~~~

Product: Ramatroban

CAS?116649-85-5

Price: USD90/g including the delivery fee

Package: 5g/bag

Assay: ?99.9%

Quantity: 5g

Delivery: shipment within 3 days, after received the payment

Payment: T/T in advance

Validity date: 7 working days


2.Pls see the quotation below~~~

Product: Ramatroban

CAS?116649-85-5

Price: USD290/g including the delivery fee

Package: 1g/bag

Assay: ?99.9%

Quantity: 1g

Delivery: shipment within 3 days, after received the payment

Payment: T/T in advance

Validity date: 7 working days

Jinan Boss Chemical Industry Co.,Ltd

90 usd for 1g in a 5g package is a very good price. But 1 g package is unaffordable.

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

OC000459


I think OC000459 is better then ramatroban! Because it wil NOT bind on the Thromboxane receptor, which should be alot mor safe!! and even cheaper

1.Pls see the quotation below~~~

Product: Ramatroban

CAS?116649-85-5

Price: USD90/g including the delivery fee

Package: 5g/bag

Assay: ?99.9%

Quantity: 5g

Delivery: shipment within 3 days, after received the payment

Payment: T/T in advance

Validity date: 7 working days


2.Pls see the quotation below~~~

Product: Ramatroban

CAS?116649-85-5

Price: USD290/g including the delivery fee

Package: 1g/bag

Assay: ?99.9%

Quantity: 1g

Delivery: shipment within 3 days, after received the payment

Payment: T/T in advance

Validity date: 7 working days