Newly Discovered Factor in Androgenetic Alopecia. The Cure is Near?

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

Effect of minoxidil on platelet function and the synthesis of prostaglandins in platelets.
O'Barr TP, Swanson EW, Fitzpatrick JE, Corby DG.
Source

Department of Clinical Investigation, Fitzsimons Army Medical Center.
Abstract

At the 12.5 micrograms level, minoxidil prevents the irreversible aggregation of platelets by 2 x 10(-6) mol/L adenosine diphosphate (ADP). Levels of minoxidil greater than 12.5 micrograms cause a reversal of primary aggregation by 2 x 10(-6) mol/L ADP. Aggregation of platelets in response to 125 micrograms of arachidonic acid is measurably reduced by 12.5 micrograms of minoxidil and totally suppressed by 30 micrograms. Concurrent with the inhibition of platelet aggregation, increasing concentrations of minoxidil cause a gradual reduction in the synthesis of prostaglandin E2 (PGE2) and thromboxane B2 (TxB2). In the presence of 100 micrograms of minoxidil, PGE2 is reduced from a control value of 87.7 +/- 2.2 pg/ml to 23.9 +/- 3.2 pg/ml. At this level of minoxidil, TxB2 drops from 105 +/- 3.3 ng/ml to 10.5 +/- 2.6 ng/ml. The effect of minoxidil on platelet aggregation is not associated with increased cyclic adenosine monophosphate synthesis. All data support the conclusion that minoxidil functions (in platelet metabolism) primarily as a cyclooxygenase inhibitor.

COX-1 is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin. TXA2, the major product of COX-1 in platelets, induces platelet aggregation

if thats the case, why hasnt minoxidil cured baldness?

LOL..stupid question. but all I can say is people have better results with several applications within the day that 2. male pattern baldness is a result of inflammation that just getting worst with time and minoxidil cannot keep up.. minoxidil induces platelet aggreagation but still limited.. Why when you quit minoxidil you shed and lose your hair..?? :whistle:

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

PGD2 is not elevated throughout your entire body.... somehow the entire problem is isolated to your scalp

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

PGD2 is not elevated throughout your entire body.... somehow the entire problem is isolated to your scalp

Back up this very statement 2020.

 

[Jacob]

Re: A recently discovered new factor in AA, the cure is near

I've also decided to experiment with topical applications of cetrizine!

Any updates from the guys who started earlier? Sheds, hair growth, hair feels healthier etc?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751243/

Cetirizine, an effective, minimally sedating, second-generation H1-antihistamine is widely used orally to treat allergic skin disorders. This study was performed to assess the peripheral H1-antihistaminic activity and extent of systemic absorption of cetirizine from liposomes applied to the skin. Cetirizine was incorporated into small unilamellar vesicles (SUV) and multilamellar vesicles (MLV) prepared using L-?-phosphatidylcholine hydrogenated (HPC), and into Glaxal Base (GB) as the control. In a randomized, crossover study, each formulation, containing 10 mg of cetirizine, was applied to the depilated backs of 6 rabbits (3.08±0.05 kg). Histamine-induced wheal tests and blood sampling were performed before cetirizine application and at designated times for up to 24 hours afterwards. Compared with baseline, histamine-induced wheal formation was suppressed by cetirizine in SUV only at 24 hours, in MLV from 0.5 to 24 hours, and in GB from 0.5 to 8 hours (P<.05). Wheal suppression by cetirizine in SUV at 24 hours (91.7%±5.2%) and in MLV from 1 to 24 hours (93.8%±2.2% to 76.2%±6.5%) was greater than in GB (36.5%±7.4% to 60.6%±14.2%) from 1 to 24 hours (P<.05). Faster onset, as well as greater and more persistent suppression was obtained from cetirizine in MLV. Plasma cetirizine concentrations from MLV (area under the curve [AUC] of 221.2±42.3 ng.hr/mL) were lower than from GB (AUC of 248.3±34.6 ng.hr/mL). In this model, cetirizine from MLV had excellent topical H1-antihistamine activity, while systemic exposure was reduced, compared with cetirizine from GB.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

PGD2 is not elevated throughout your entire body.... somehow the entire problem is isolated to your scalp

Back up this very statement 2020.

which part? If PGD2 were to be elevated throughout your entire body, you would definitely "feel it"...

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

PGD2 is not elevated throughout your entire body.... somehow the entire problem is isolated to your scalp

Back up this very statement 2020.

which part? If PGD2 were to be elevated throughout your entire body, you would definitely "feel it"...

LOL OK.. there is a shitload of studies on Pudmed which are more relevant than just feeling it from 2020 LOL that totally prove that early male pattern baldness is a sign of many others diseases like prostate cancer, heart diseases, insulin resistance... :bravo:

 

[mj9]

Re: A recently discovered new factor in AA, the cure is near

I've also decided to experiment with topical applications of cetrizine!

Any updates from the guys who started earlier? Sheds, hair growth, hair feels healthier etc?

How have you made your solution?

- Cetirizine from tablets or as a liquid?
- Which vehicle? in minoxidil?

Cetirizine mixed in minoxidil liquid. minoxidil has not down anything in terms of new hair growth (only maintained) for the past 2-3 years, so IF my hair suddenly start to get thicker, then it has to be Cetrizine.

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

Since I can not do everything on my OWN, I need some help of you guys!!

For the people that can read studies, and have time for it, Do me a favor, and start reading as much as possible, the more we know the better, and the better we can lay links btween the PG's and other involved hormones.

Here are couple hundred studies about PGD2
http://www.ncbi.nlm.nih.gov/pubmed?term=prostaglandin d2
-----------------------------------------------------------------------------------------
here are couple thousand studies about PGF2Alpha
http://www.ncbi.nlm.nih.gov/pubmed?term=prostaglandin f2 alpha
-----------------------------------------------------------------------------------------

here are couple thousand studies about PGE2
http://www.ncbi.nlm.nih.gov/pubmed?term=prostaglandin E2
-----------------------------------------------------------------------------------------


Its very important to understand each role of the pg's in our body.

I know just since couple days that PGF2alpga (that people are using on their scalpes because it helps on the eyelashes, that its highers testosterone by 100%)

Its important to understand the role of pgf2alpha and E2, this is my aim at the moment. the more knowledge we have, the easier the puzzle gets!!

 

[antman]

Re: A recently discovered new factor in AA, the cure is near

PGD2 is not elevated throughout your entire body.... somehow the entire problem is isolated to your scalp

Back up this very statement 2020.

which part? If PGD2 were to be elevated throughout your entire body, you would definitely "feel it"...

LOL OK.. there is a shitload of studies on Pudmed which are more relevant than just feeling it from 2020 LOL that totally prove that early male pattern baldness is a sign of many others diseases like prostate cancer, heart diseases, insulin resistance... :bravo:

i thought the problem of elevated inflammatory eicosanoids (eg PGD2) without the resolvins and protectins and other anti-inflammatory eicosanoids was that it is 'silent inflammation' and as such nobody notices it.

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

I feel there is a lack of skilled people on this forum. the most people are followers that expect the perfect solutions just falls out of the sky.

I need more help here. PM me or something, I need a group of expert together to debate some things.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

I feel there is a lack of skilled people on this forum. the most people are followers that expect the perfect solutions just falls out of the sky.

I need more help here. PM me or something, I need a group of expert together to debate some things.

post everything you want to debate here

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

I feel there is a lack of skilled people on this forum. the most people are followers that expect the perfect solutions just falls out of the sky.

I need more help here. PM me or something, I need a group of expert together to debate some things.

post everything you want to debate here

I guess, you don't get the picture. read my earlier post with the studies. I need a bit more involvement from more people.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

there's not much you can research.... we need scientists to actually conduct experiments and then learn from that.

For example: what would happen if you applied large amounts of PGD2 on your donor hair? Will it shrink?

find a bunch of castrated people. Measure their PGD2 levels on their scalp.

.... on and on.... I don't see why they couldn't do so many obvious experiments over the weekend or something...

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

there's not much you can research.... we need scientists to actually conduct experiments and then learn from that.

For example: what would happen if you applied large amounts of PGD2 on your donor hair? Will it shrink?

find a bunch of castrated people. Measure their PGD2 levels on their scalp.

.... on and on.... I don't see why they couldn't do so many obvious experiments over the weekend or something...

still, we could learn allot, there are thousands of studies on pubmed, that can bring us closer to solve the puzzle, for example, we now know PGF2 alpha increases testosterone more then 100%, these levels are elevated in the scalp. while PG2E, should do the opposite with testosterone(not sure yet have to read more), wich these levels are down regulated.


We need the perfect solution for full regrowth.

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

Some interesting stuff to read:
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033329


http://zon.tchlab.org/LordCC6-24.pdf

We have recently demonstrated through a chemical screen in the zebrafish embryo 
that prostaglandin E2 (PGE2) is an evolutionarily conserved regulator of hematopoietic 
stem cell (HSC) number. These results have further been confirmed by in vitro and in 
vivo studies in the murine model. Bioactive PGE2 derivatives have potential clinical 
application to accelerate recovery of the hematopoietic system following chemotherapy 
or irradiation. Ex vivo expansion of HSCs prior to stem cell transplantation may improve 
reconstitution of hematopoiesis and immune function. This article aims to summarize 
current knowledge of PGE2-mediated regulation of blood cell homeostasis as well as to 
discuss the proposed use of PGE2 to expand hematopoietic stem cells for transplantation 
in the clinical setting

PGE2 sounds very promising for me.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

yes, but prostaglandins are just "messengers" for various body functions... they themselves don't actually do anything.
PGE2 may be good for hair, but it's actually bad for your heart.... I'm sure PGD2 itself has many good functions for the rest for your body it's just that in scalp it triggers an unwanted function - follicle shrinking.

You won't get anywhere if you just research "prostaglandins"...

 

[Joshuk]

Re: A recently discovered new factor in AA, the cure is near

my certzine tablets came this weekend and i do not know to make a topical or just take them orally, might try both or something.

would their be a diffrence at all between orally or topical.

also does anyone know if this PG is the right stuff? i know abit off topic but im going to change my vehicle for RU

https://onlinesecureshop.co.uk/epages/y ... ts/J100PG&

I am going to read up some studies aswell on PGD2 this week and post anything i find out

 

[Fight Your Genes]

Re: A recently discovered new factor in AA, the cure is near

In response to boldy, ive been causally reading through some studies about PGD2 on pubmed, It appears that PGD2 is crucial for Sleep.

Here is the study

http://www.ncbi.nlm.nih.gov/pubmed/22024172 (hope the link works!)

It gets me thinking that oral PGD2 inhibitors that lower PGD2 around the body may have systematic side effects and that topical inhibitors are the way to go!

Another study touches on the connection between testosterone and PGD2 quite interesting

http://www.ncbi.nlm.nih.gov/pubmed/22612476

More than half the pregnant women in the Western world report taking mild analgesics. These pharmaceutical compounds have been associated with congenital cryptorchidism in humans, the best-known risk factor for low semen quality and testicular germ cell cancer. Furthermore, some of these mild analgesics exert potent anti-androgenic effects in the male rat and several endocrine-disrupting compounds, known to alter masculinization, have also been shown to be potent inhibitors of prostaglandin (PG) synthesis similar to mild analgesics. Using a 3-day ex vivo organotypic model system based on gestational day 14.5 rat testes, we herein show that testosterone production was inhibited by paracetamol, at doses of 0.1??m to 100??m. Similar results were obtained for aspirin (1-100??m) and indomethacin (10??m). The production of the other Leydig cell hormone, Insl3, was not disrupted by exposure to paracetamol. Investigations of the gross anatomy of the testis as well as Leydig cells number and rate of gonocyte apoptosis after the 3?days of ex vivo differentiation showed no significant effect of the analgesics tested compared with controls. These data indicate therefore that mild analgesics specifically inhibit testosterone production in rat foetal testes in vitro and that these compounds had no effect on gonocyte survival. Parallel determinations of prostaglandin D2 (PGD2) production indicated that the effects of paracetamol and aspirin on PGD2 and testosterone were not connected, whereas the effects of indomethacin were correlated. We conclude that mild analgesics exert direct and specific anti-androgenic effects in rat foetal testis in our experimental setup and that the mechanism of action is probably uncoupled from the inhibition of PG synthesis.

 

[Fight Your Genes]

Re: A recently discovered new factor in AA, the cure is near

Another PGD2 Inhibiting drug

http://www.ncbi.nlm.nih.gov/pubmed/22110163

in stage one clinical trials it seems

http://www.panmira.com/pipeline.html

PGD2 is produced at higher levels during allergic inflammation and the presence of white blood cells (Eosinophils) enables higher production is seems.

http://www.ncbi.nlm.nih.gov/pubmed/22102725

http://www.ncbi.nlm.nih.gov/pubmed/16424158

Here is a quote form the first study
''Our findings reveal that eosinophils are indeed able to synthesize and secrete PGD(2), hence representing during allergic inflammation an extra cell source of PGD(2), which functions as an autocrine signal for eosinophil activation''

I dont know much at all lads but all these studies on Pubmed and there are Loads connect PGD2 with an allergic/inflammatory response wherever it is secreted, this all hints that male pattern baldness and its slow progression is an inflammatory disorder.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

READ MY PREVIOUS POST:

yes, but prostaglandins are just "messengers" for various body functions... they themselves don't actually do anything.
PGE2 may be good for hair, but it's actually bad for your heart.... I'm sure PGD2 itself has many good functions for the rest for your body it's just that in scalp it triggers an unwanted function - follicle shrinking.

You won't get anywhere if you just research "prostaglandins"...