nizoral 1% for 60-90 seconds- is it gonna make a difference?

[Mircalegro]

I can only use nizoral 1% for up to a minute and a half, and i have learned that the hard way multiple times (most recently i am dealing with red spots and irritation for experimenting with leaving it in longer a few days last week)

so im gonna take a few days off from using it, then come back to the 60-90 second routine 3x weekly, as my scalp can stand that and im sure its good for something...if even just to clear away sebum and stuff.

What i wanna know is- is this short window of time enough to get any anti-androgenic benefit?

thanks

 

[darren1234]

I'm no expert, but if you're getting spots and irritation it might be because you're having a bad reaction to ketoconozole, as i think most people don't experience this. If this is the case, the inflammation may do more harm than good. As far as i'm aware keto is a weak anti-androgen anyway, so 60-90 seconds probs wont do alot. I would suggest trying other treatments.

 

[John979]

This is a question where some proper research can be very helpful, but I am more concerned with systemic side effects.

 

[Oren19]

b"h

i'm don't sure if it's safe, but if you want, you can search in google: "ketoconazole cream" and try it (ketoconazole is the active ingredient on nizoral)

you can try to ask a doctor for safetly.. if you want, try nizoral cream! don't use nizoral shampoo for 5 + mins..

see this link, it's about nizoral cream:
http://drug.co.il/bygeneric.asp?gen_id=762&drugID=2891
i'm don't sure the cream version is good for hair

 

[John979]

b"h

i'm don't sure if it's safe, but if you want, you can search in google: "ketoconazole cream" and try it (ketoconazole is the active ingredient on nizoral)

you can try to ask a doctor for safetly.. if you want, try nizoral cream! don't use nizoral shampoo for 5 + mins..

see this link, it's about nizoral cream:
http://drug.co.il/bygeneric.asp?gen_id=762&drugID=2891
i'm don't sure the cream version is good for hair

Have had no problems even with shampoo more than 5 mins.

But, as I said, this is an area where some really research would be good. However, the "system" does not reward research using older products, which is a shame and along with the same being true for combinations, is the main reason why an effective treatment is not on the market.

They certainly exist, and have so for years.

 

[Oren19]

b"h

john, nizoral shampoo contain SLS or SLES (i'm dont sure) , i'm think it's don't healty for the human hair, but not sure. 5 min is the recommanded..

 

[cristi2011]

I'm no expert, but if you're getting spots and irritation it might be because you're having a bad reaction to ketoconozole, as i think most people don't experience this. If this is the case, the inflammation may do more harm than good. As far as i'm aware keto is a weak anti-androgen anyway, so 60-90 seconds probs wont do alot. I would suggest trying other treatments.

That reaction is not because of keto. That ingredient is in the lowest
quantity from all, afterall.(1%)
But if you read on the shampoo bottle, you'll see that Nizoral contains aprox 10 other harsh chemicals: SLS, and even "concentrated clorhydric acid"(wtf??). I don't get how those rest of 99% chemical crap could help your hair...Never understood why manufactureres really have to but so much bullshit in a shampoo...

 

[slurms mackenzie]

I can only use nizoral 1% for up to a minute and a half, and i have learned that the hard way multiple times (most recently i am dealing with red spots and irritation for experimenting with leaving it in longer a few days last week)

so im gonna take a few days off from using it, then come back to the 60-90 second routine 3x weekly, as my scalp can stand that and im sure its good for something...if even just to clear away sebum and stuff.

What i wanna know is- is this short window of time enough to get any anti-androgenic benefit?

thanks

I've suffered from the same problems in the past so went from using nizoral 2% to nizoral 1%, then nothing, i guess some peoples scalps just weren't meant for nizoral, it could be the shampoo that's the problem, and some people report moving over to over shampoos such as revita gives some benefit.

In terms of the time window, no-one can give you a definitive answer the studies were never done using that time frame, and anybody worried about hair loss worried about hair loss wouldn't chance it to using only nizoral 60-90 seconds a week.

If you're brave, why not try the cream?

 

[slurms mackenzie]

This is a question where some proper research can be very helpful, but I am more concerned with systemic side effects.

Okay now i said i'd consider some keto cream in the above post, I'm slightly worried, as i'd tried to search for systemic effects and found this reassuring post

A more recent study using advanced technology reported after an approx 5 gram topical application of 2% ketoconazole (approx 100 mg keto) mean plasma keto levels were 0.5 ng / ml.

I am not "putting a lot on my head," and given that a 30 gram tube of 2% keto lasts me a month, the applied about is one fifth that of the study. The result would be undectable plasma levels of keto, less than 0.05 ng / ml.

Please tell me you have a link to the study

5ng is f*** all right?

 

[John979]

This is a question where some proper research can be very helpful, but I am more concerned with systemic side effects.

Okay now i said i'd consider some keto cream in the above post, I'm slightly worried, as i'd tried to search for systemic effects and found this reassuring post

A more recent study using advanced technology reported after an approx 5 gram topical application of 2% ketoconazole (approx 100 mg keto) mean plasma keto levels were 0.5 ng / ml.

I am not "putting a lot on my head," and given that a 30 gram tube of 2% keto lasts me a month, the applied about is one fifth that of the study. The result would be undectable plasma levels of keto, less than 0.05 ng / ml.

Please tell me you have a link to the study

5ng is f*** all right?

That study is correct. However, a later study with more sensitive equipment measured somewhat higher levels, but that was also on dry skin. Still, I don't think there is much systemic absorbtion from keto.

My comment was intended to be more general than specific.

 

[maidstone]

After using it only 3 times across a week and a half I've decided to stop using it altogether.

My experience has been quite negative even though I used 1% and I leave it on my head for around 2 - 3 mins. It not only gave me headaches and brain-fog, it made my scalp incredibly dry and shed my hair intensely (losing more than 200 hairs straight after each usage).

I wish I could say that I was only shedding telogen hairs that I was going to lose anyway but I was shedding hairs of all size, lengths, width, etc.

 

[slurms mackenzie]

This is a question where some proper research can be very helpful, but I am more concerned with systemic side effects

A more recent study using advanced technology reported after an approx 5 gram topical application of 2% ketoconazole (approx 100 mg keto) mean plasma keto levels were 0.5 ng / ml.

I am not "putting a lot on my head," and given that a 30 gram tube of 2% keto lasts me a month, the applied about is one fifth that of the study. The result would be undectable plasma levels of keto, less than 0.05 ng / m

That study is correct. However, a later study with more sensitive equipment measured somewhat higher levels, but that was also on dry skin. Still, I don't think there is much systemic absorbtion from keto.

My comment was intended to be more general than specific.

http://rosacea-support.org/sebazole-top ... gel-2.html

I think this may be the second study.

Conclusions: Subjects with severe seborrheic dermatitis who apply ketoconazole USP 2% topical gel once daily for 2 weeks to affected areas have limited systemic absorption of ketoconazole. These results agree with results from studies of other topical ketoconazole formulations where levels were non-quantifiable when less sensitive assays (LLOQ 1-5 ng/mL) were used. The median Cmax and AUC were 6700 and 1700 times lower than values reported after oral dosing of 200 mg ketoconazole. In the subject with the highest ketoconazole levels, Cmax and AUC were still 250 and 75 times lower than after 200 mg orally.

 

[John979]

What I would like to see are dose-time-effect studies, essentially ones showing drug x only need application at y concentration for z dutation to be fully effective topically.

While keto absobtion is low, if it only need be applied for one hour at 2%, absorbtion would be even lower.