No news over the past few months

[Pray The Bald Away]

Stemoxydine is a prolyl-4-hydroxylase inhibitor. Hypoxia signaling is mediated by the HIF-1A transcription factor and is degraded by prolyl-4-hydroxylase. So in short it induces HIF-1A favoring a more hypoxic environment for the cells.

If we look at the WNT pathway in relation to hair follicle biology it plays a immense role. It has a huge role in hair follicle cycling, also in the creation of the hair follicle (morphogenesis). On a genetic level WNT10A has also been associated with Androgenetic Alopecia.

I'm with Hairloss23 though that compounds like valproic acid, lithium etc. which work through GSK3-B inhibition also induce b-catenin (http://www.ncbi.nlm.nih.gov/pubmed/24533507). Now SM is a molecule that apparently targets b-catenin directly and AFAIK is the first molecule ever which works like this and hit clinical trials. Hopefully it will do (significantly) better than minoxidil, who knows... The results will be important imo. We will know the results in 2 days.

Androgenetic Alopecia is just one big beast though. Extremely hard to reverse as we all know.

Future prospects are getting weaker and weaker, at least for the near future which sucks. At the moment I see the hair transplant industry dominating the ranks for the coming years easily. I would love to be proven wrong though.

Do you think SM04554 has the potential to maintain hair like finasteride, or will it just be glue like minoxidil? You seem to know a lot about the hard science of these treatments.

 

[FWIW]

There has been big advance in hair transplants. You can practically cover hairloss with finasteride and hair transplant with reputable surgeon up to NW4 quite easily. There will be first follicle multiplication than any regrowth medicament.

 

[hilbert]

Future prospects are getting weaker and weaker, at least for the near future which sucks. At the moment I see the hair transplant industry dominating the ranks for the coming years easily. I would love to be proven wrong though.

imho not; hair transplant industry need their patients on finasteride/dutasteride. Where did a first serious (though fail) attempt for a topical finasteride come from? hair transplant industry.
They know they won't be able to put and keep their patients on a decent look... maybe only the lucky ones destined to a NW3 max.
So, it still depends a lot on maintenance drugs, until donor multiplication or follicle cloning will be available.

Concerning the new things around the corner... Well, I'm a pessimist by nature, maybe also because I've been fighting with male pattern baldness for 25 years. And still I don't want / can't surrender (shaving is not an option for me after 1 big hair transplant + 2 minor ones).

But but... there is actually something we can hope for in a ~2 years range. Histogen, Replicel, Samumed.
(no, Polichem's topical fina is disappointing imho; they proved that they only way to make it almost not systemic is to put max 0,2ml on your head. congrats).

As a pessimist, I'm always looking for negatives in these 3, but so far it seems they're all on a good pace, and based on solid science.
Uhm, am I trying to convince myself?

 

[Hairloss23]

There has been big advance in hair transplants. You can practically cover hairloss with finasteride and hair transplant with reputable surgeon up to NW4 quite easily. There will be first follicle multiplication than any regrowth medicament.

Doesn't look realistic and still very thin compared to original hair. Also high chance of butchery, literally of all the hair transplant surgeons in the world I would only trust like 4 to give me a hair transplant. Also who wants to wait till they're stone cold bald to get their hair back, and no one wants to do touch up as you go option in case they run out of grafts.

 

[Swoop]

Do you think SM04554 has the potential to maintain hair like finasteride, or will it just be glue like minoxidil? You seem to know a lot about the hard science of these treatments.

No, I don't think so. Even I myself feel threatened for the future if my Androgenetic Alopecia kicks into overdrive. That will leave me with no other options but to hit the androgen/AR angle even harder which will come with side effects for me.

Let's see what SM can bring though, 1 day left!

 

[kmm179]

Stemoxydine is a prolyl-4-hydroxylase inhibitor. Hypoxia signaling is mediated by the HIF-1A transcription factor and is degraded by prolyl-4-hydroxylase. So in short it induces HIF-1A favoring a more hypoxic environment for the cells.

If we look at the WNT pathway in relation to hair follicle biology it plays a immense role. It has a huge role in hair follicle cycling, also in the creation of the hair follicle (morphogenesis). On a genetic level WNT10A has also been associated with Androgenetic Alopecia.

I'm with Hairloss23 though that compounds like valproic acid, lithium etc. which work through GSK3-B inhibition also induce b-catenin (http://www.ncbi.nlm.nih.gov/pubmed/24533507). Now SM is a molecule that apparently targets b-catenin directly and AFAIK is the first molecule ever which works like this and hit clinical trials. Hopefully it will do (significantly) better than minoxidil, who knows... The results will be important imo. We will know the results in 2 days.

Androgenetic Alopecia is just one big beast though. Extremely hard to reverse as we all know.

Future prospects are getting weaker and weaker, at least for the near future which sucks. At the moment I see the hair transplant industry dominating the ranks for the coming years easily. I would love to be proven wrong though.

Swoop can you find the cure already?

With what s going treatment wise makes me think they know they cant solve. So why waste time and research on a risky investment by researching treatments. If these people and companies thought they could really make money/an impact treatment there would be so many more products in the pipeline.

Also werent minoxidil and finasteride found by accident to treat hair? So technically research and development has really produced nothing....

 

[Swoop]

@kmm179, Haha.. I wish I could.

Honestly looking at these companies is pretty laughable these days. I'm sure actually that the hair transplant industry is going to dominate the ranks in the near future.

Again, bottom line is that Androgenetic Alopecia is incredibly hard to reverse. And late Androgenetic Alopecia seem to reflect an irreversible state anyway. And like you say, we have no clue on how to actually deal with this problem. Not even proper models to go by LOL. Totally f*cking clueless. It's a very cruel hard-wired pathology.

I'm also close to 100% sure that Androgenetic Alopecia won't ever be cured from a drug that acts selectively on a pathway, even a multi angle approach won't do it. And again, late Androgenetic Alopecia in some people is irreversible anyway. Only the creation of new hair follicles will do in this case.

The best treatment wise what we are going to have in the next years is still hitting the Androgen/AR angle as hard as possible + minoxidil + the oh so feminizing 17b-estradiol. The rest will be sub-par to that from the current pipeline.

Regenerative therapy is where it's at in the future. But we are talking at 10+ years easily. That will give you one day a full head of hair and will most likely act as a reversal cure.

Going back to your initial point by the way.. The preventative cure is there already in a broad sense. And I wouldn't be surprised if that is going to deal with Androgenetic Alopecia in the future. We are talking about gene therapy

here; http://www.ncbi.nlm.nih.gov/pubmed/19186031

Quite simply we know that if we silence the androgen receptor to full extent, Androgenetic Alopecia will never proceed. Treatments like RU-58841 and CB-03-01 have their downsides because they are too weak to fully deal with the AR, need to be used continuously, pose the risk of side effects because of systemic accumulation, hypothetically the AR might adapt etc.

Gene therapy? Can take care all of that. In fact in the study here above they used a antisense oligonucleotide and a small interfering RNA to silence the androgen receptor in vitro on dermal papilla cells. The antisense oligonucleotide inhibited AR function 100%.

Imagine something better than castration without the downsides that will work for a long amount of time. Truth being told some things still need to be worked on.. However it's realistic to assume that gene therapy to silence the AR will be a real possibility and it might come sooner than you think. The biggest problem won't be if we can't do it (because enough studies show big promise already also related to AR silencing , and enough gene therapy clinical trials are running related to other stuff), but the biggest problem will be the ethical questions that are going to be asked.

Is it ethical to use gene therapy for a cosmetic problem? Because that is how the public is going to look at it.

But yeah, the current things in the clinical trials are looking weak as hell, can't make anything else out of it unfortunately.

 

[c_super2]

Some people shoudnt be so pessimistic. Even failures are a step forward.

@kmm179, Haha.. I wish I could.

Honestly looking at these companies is pretty laughable these days. I'm sure actually that the hair transplant industry is going to dominate the ranks in the near future.

Again, bottom line is that Androgenetic Alopecia is incredibly hard to reverse. And late Androgenetic Alopecia seem to reflect an irreversible state anyway. And like you say, we have no clue on how to actually deal with this problem. Not even proper models to go by LOL. Totally f*cking clueless. It's a very cruel hard-wired pathology.

I'm also close to 100% sure that Androgenetic Alopecia won't ever be cured from a drug that acts selectively on a pathway, even a multi angle approach won't do it. And again, late Androgenetic Alopecia in some people is irreversible anyway. Only the creation of new hair follicles will do in this case.

The best treatment wise what we are going to have in the next years is still hitting the Androgen/AR angle as hard as possible + minoxidil + the oh so feminizing 17b-estradiol. The rest will be sub-par to that from the current pipeline.

Regenerative therapy is where it's at in the future. But we are talking at 10+ years easily. That will give you one day a full head of hair and will most likely act as a reversal cure.

Going back to your initial point by the way.. The preventative cure is there already in a broad sense. And I wouldn't be surprised if that is going to deal with Androgenetic Alopecia in the future. We are talking about gene therapy

here; http://www.ncbi.nlm.nih.gov/pubmed/19186031

Quite simply we know that if we silence the androgen receptor to full extent, Androgenetic Alopecia will never proceed. Treatments like RU-58841 and CB-03-01 have their downsides because they are too weak to fully deal with the AR, need to be used continuously, pose the risk of side effects because of systemic accumulation, hypothetically the AR might adapt etc.

Gene therapy? Can take care all of that. In fact in the study here above they used a antisense oligonucleotide and a small interfering RNA to silence the androgen receptor in vivo on dermal papilla cells. The antisense oligonucleotide inhibited AR function 100%.

Imagine something better than castration without the downsides that will work for a long amount of time. Truth being told some things still need to be worked on.. However it's realistic to assume that gene therapy to silence the AR will be a real possibility and it might come sooner than you think. The biggest problem won't be if we can't do it (because enough studies show big promise already also related to AR silencing , and enough gene therapy clinical trials are running related to other stuff), but the biggest problem will be the ethical questions that are going to be asked.

Is it ethical to use gene therapy for a cosmetic problem? Because that is how the public is going to look at it.

But yeah, the current things in the clinical trials are looking weak as hell, can't make anything else out of it unfortunately.

Dr. Cotsarelis and Dr. Christiano said a few times that if they can get the stem cells activated they can maybe restore hair growth. What are your thoughts?

 

[GiveMeAccessToMyAccount]

FUE/finasteride/dutasteride/minoxidil for life.

 

[paleocapa89]

It will be a happy future for the next generation. They will get their vaccination for polio and measles etc. in their arm and the vaccination against male pattern baldness in their scalp.

 

[g.i joey]

FUE/finasteride/dutasteride/minoxidil for life.

not if 30% of the time you cant stay hard to bang ur gf... lol

 

[Swoop]

Some people shoudnt be so pessimistic. Even failures are a step forward.

Dr. Cotsarelis and Dr. Christiano said a few times that if they can get the stem cells activated they can maybe restore hair growth. What are your thoughts?

I'm a full blown realist at heart mate.

I think hair growth can be restored to a certain timeline. Like I said though late Androgenetic Alopecia in some people is irreversible anyway. The hair follicle structure simply gets infiltrated and destroyed. Only the creation of a new hair follicle will do in this case. You can't revive something that isn't there anymore.

Overall, yes it can be restored to a certain amount depending on the individual, as estrogen with castration is the proof of this and we know this for a long time. As Dr. Cotsarelis mentions which is true;

Dr. Cotsarelis: We know that inhibiting the testosterone pathway slows down the miniaturization of the follicle. Jaworsky, Kligman, and Murphy had a paper 20 years ago showing that half the time there is also inflammation around the hair follicle, which led to some thought that maybe inflammatory cells including mast cells were contributing to hair loss. Studies and case reports of transgender operations where men become women and receive high doses of estrogen show that a scalp that was almost completely bald can have, after castration and high estrogen supplementation, a tremendous amount of hair growth.

So hypothetically, yes there are probably pathways can restore hair growth equally to estrogen and maybe even better. That being said it's pretty much mission impossible to achieve that, for very obvious reasons.

And what do you think?

 

[Armando Jose]

Where are the photos of Cotsarellis regarding new hair in transgender?

 

[Swoop]

Where are the photos of Cotsarellis regarding new hair in transgender?

There is a transsexual on this forum, go check the success forum for the pictures. And another guy is doing a heavy regimen on suppressing androgen/AR and adding in estrogen. Here is a case report for example; http://www.ncbi.nlm.nih.gov/pubmed?...ive androgenetic alopecia on estrogen therapy.

There are also pictures floating around you have to find them, I posted them somewhere. It doesn't matter though no man should touch this stuff, also it doesn't happen always.

Here are two;

 

[Janko]

http://img.memecdn.com/has-science-gone-too-slow_o_3996575.webp

 

[GiveMeAccessToMyAccount]

not if 30% of the time you cant stay hard to bang ur gf... lol

No hair = no gf.

 

[g.i joey]

Only at gourmetstylewellness.com ^

 

[paleocapa89]

It's f***ing depressing to admit it, but I have to say Pilofocus has just become interesting again..

 

[Follisket]

It's f***ing depressing to admit it, but I have to say Pilofocus has just become interesting again..

Why, has decent donor regeneration suddenly been confirmed?

But really, I feel there've been plenty of news over the past few months - it's just that practically all of them have been insanely bad.

 

[Armando Jose]

There is a transsexual on this forum, go check the success forum for the pictures. And another guy is doing a heavy regimen on suppressing androgen/AR and adding in estrogen. Here is a case report for example; http://www.ncbi.nlm.nih.gov/pubmed?...ive androgenetic alopecia on estrogen therapy.

There are also pictures floating around you have to find them, I posted them somewhere. It doesn't matter though no man should touch this stuff, also it doesn't happen always.

Here are two;

Hi friend, thak you for the photos, but
the male/female is published in a hair trasplant web
http://www.forhair.com/hair-transplant-photos/women/patient-tgs/woman/