Official Hellouser To Kyoto Hair Congress 2017 Fund
- Thread starter hellouser
- Start date
- Status
- Reaction score
- 4,504
Looks like the bare minimum was reached!
sh*t!
You are going!
sh*t!
You are going!
The conference was canceled due to insufficient funds. Damn
- Reaction score
- 419
Do you ever shut up?The conference was canceled due to insufficient funds. Damn
- Reaction score
- 136
Nothing now, wait for a week.
--------------------------
Could we get filters for people U20 and highlighters for hellouser and Noisette?
- Reaction score
- 3,025
Hellouser, I'd very much appreciate if you get a chance to ask any of the Replicel (or any stem cell guys) what they think about the potential for in vitro stem cell multiplication to lead to cancer cells which might be implanted into the scalp.
It has been demonstrated in studies that in vitro stem cell multiplication may lead to deregulation of cells causing cancers to develop. When cells multiply in the body, there are checks and balances to fix errors and destroy damaged cells that don't exist when multiplying in vitro.
I wonder whether they have any ideas for how this could be monitored or assessed before re-implantation into the scalp occurs.
Here is a reference on the subject perhaps it might be helpful to become familiar with either way:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070641/
To quote the most pertinent section:
This is critically important as more and more guys are turning to the stem cell research teams like Replicel with their hopes and if even one case leads to tumor formation it is going to be catastrophic.
We need safety mechanisms in place (or at least discussion of the risk) to potentially prevent any horrifying outcomes.
It has been demonstrated in studies that in vitro stem cell multiplication may lead to deregulation of cells causing cancers to develop. When cells multiply in the body, there are checks and balances to fix errors and destroy damaged cells that don't exist when multiplying in vitro.
I wonder whether they have any ideas for how this could be monitored or assessed before re-implantation into the scalp occurs.
Here is a reference on the subject perhaps it might be helpful to become familiar with either way:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070641/
To quote the most pertinent section:
In vitro expansion and culture of stem cells can change the characteristics of the stem cell due to intracellular and extracellular influences. Every cell division has a small chance of introducing deleterious mutations and mechanisms to correct these alterations may not function as adequate (e.g. cell cycle arrest, DNA repair), or at all (e.g. immune recognition) occur during in vitro culture. Cell culture induced copy number changes and loss of heterozygosity have been reported for hESC lines [54]. In principle, such changes may cause transformation of a cell into a tumourigenic phenotype and may contribute to increased tumour formation. The clinical relevance (with regard to tumourigenic potential) of these alterations (e.g. chromosomal aberrations) still remains a matter of debate [40]. Some reports indicated that the tumourigenicity of stem cells has been predicted to increase proportionally with the length of in vitro culturing [43]. In vitro ESC lines have been reported to show a certain degree of deregulation of the so-called imprinted genes, also after differentiation [20].
Spontaneous malignant transformation of mouse MSC following long term in vitro culture has been described [55-57]. Also spontaneous transformation of mice neural precursor/stem cells has been reported [58]. These transformed cells were detected already after ~10 passages of cell culture, and produced tumours in vivo upon administration into rodent brains.
Spontaneous malignant transformation of mouse MSC following long term in vitro culture has been described [55-57]. Also spontaneous transformation of mice neural precursor/stem cells has been reported [58]. These transformed cells were detected already after ~10 passages of cell culture, and produced tumours in vivo upon administration into rodent brains.
This is critically important as more and more guys are turning to the stem cell research teams like Replicel with their hopes and if even one case leads to tumor formation it is going to be catastrophic.
We need safety mechanisms in place (or at least discussion of the risk) to potentially prevent any horrifying outcomes.
Did you close the go fund me?
- Reaction score
- 2,634
Nope, it's still open. You should still be able to make donations.
- Reaction score
- 83
yeah im praying, hair loss is just sad!
Shouldn't be something a person who isn't even an adult yet should have to go through, so definitely killing myself if there's no good news.
- Reaction score
- 83
me too im 18 next year.
Last edited:
Yep 19 here, it's funny where I go to school everybody is rich and their parents buy them all their sh*t, im the opposite and have to even contribute with rent everybody here thinks they have it hard having mommy and daddy pay for their tuition and cars and I'm over here paying for my own sh*t and now balding, can't wait to either at least fix my hair or just end it.
- Reaction score
- 321
21 yo here guys, balding since 14 \o/
Wish you good luck hellouser !
Wish you good luck hellouser !
Damn man, 14? sh*t mine started at 17 MAYBE 16, that sucks so much, so 7 years of balding, what Norwood are you at?
- Reaction score
- 301
What Norwood are you bro?
- Status