Yeah I could see CRISPR being used to knock out the AR genes or something like that. Probably way easier then trying to attack male pattern baldness directly. I mean yeah you find hundreds of male pattern baldness genes in those studies but what does altering any of them do? No one knows so its very dangerous to mess with them, and really not worth the effort.
Possibility Of Any Treatments In 2017?
- Thread starter baldingAF
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- 2017 histogen kelopesia treatments
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I wonder sometimes what I'll do if Tsuji and Lauster fails. My hair will only survive for so long. I refuse to adopt a full hardcore anti-androgen regime. Hopefully, Shisheido will show great results. But what if they don't succeed?
It frustrates me that the solution to this problem is indeed very simple (at least on the maintenance angle)... Just knock out this goddamn AR like some have said here already above. This could be done through gene therapy. I assume the technical possibility of this is very realistic. Bringing this to the market would be more of an ethical uphill battle than a practical one.
I actually read an interview with Elon Musk recently and he said something related. Someone asked Elon Musk if he would ever "dabble" into genetic reprogramming.. His answer was:
Musk explained that it’s not really a “technical battle” as much as a “moral battle”:
“You know, I call it the Hitler Problem. Hitler was all about creating the Übermensch and genetic purity, and it’s like— how do you avoid the Hitler Problem? I don’t know
That being said I don't call knocking out AR, genetic reprogramming. But you know it's still hair loss we are dealing and not cancer....... It's still mostly seen purely as a cosmetic issue.
Two practical realistic solutions to this problem seem to be:
1. Allogenic hair transplants (since the hair follicle seems to be immune-privileged)
2. Gene therapy focused towards the AR
Both would be very hard to work out due to ethical, moral & regulatory issues etc. But at least they are realistic and highly practical. I seriously might make it my life mission to actively chase one of the two options above if all else fails.
But yeah I just hope that Tsuji or Lauster fixes this.. I believe in their method and in the observations that the hair follicle displays high plasticity & regenerative potential.
Androgenetic Alopecia itself is just absolutely brutal, though. I just want replication of my hair follicles at the back of my head whose cells aren't hardwired for "self-destruction".
It frustrates me that the solution to this problem is indeed very simple (at least on the maintenance angle)... Just knock out this goddamn AR like some have said here already above. This could be done through gene therapy. I assume the technical possibility of this is very realistic. Bringing this to the market would be more of an ethical uphill battle than a practical one.
I actually read an interview with Elon Musk recently and he said something related. Someone asked Elon Musk if he would ever "dabble" into genetic reprogramming.. His answer was:
Musk explained that it’s not really a “technical battle” as much as a “moral battle”:
“You know, I call it the Hitler Problem. Hitler was all about creating the Übermensch and genetic purity, and it’s like— how do you avoid the Hitler Problem? I don’t know
That being said I don't call knocking out AR, genetic reprogramming. But you know it's still hair loss we are dealing and not cancer....... It's still mostly seen purely as a cosmetic issue.
Two practical realistic solutions to this problem seem to be:
1. Allogenic hair transplants (since the hair follicle seems to be immune-privileged)
2. Gene therapy focused towards the AR
Both would be very hard to work out due to ethical, moral & regulatory issues etc. But at least they are realistic and highly practical. I seriously might make it my life mission to actively chase one of the two options above if all else fails.
But yeah I just hope that Tsuji or Lauster fixes this.. I believe in their method and in the observations that the hair follicle displays high plasticity & regenerative potential.
Androgenetic Alopecia itself is just absolutely brutal, though. I just want replication of my hair follicles at the back of my head whose cells aren't hardwired for "self-destruction".
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That is. Why not to try transplant few grafts (50-100) of another person on neck or arm and see how they survive. If it's ok then you can charge good money to that person for transplanting more grafts.
If it doesn't work with someone you can try to find and try another person.
https://www.ncbi.nlm.nih.gov/pubmed/10491051
Same here, that's why I'm praying everyday that i'm not heading to a high Norwood (selfish, isn't it?) so hair transplant can still be an acceptable solution when I will be older.
You should also check what Poietis is working on (backed by l'Oreal), they could be a great solution.
We should try to make a Q&A with them - happy to help since I'm French.
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Swoop, aren't you maintaining on finasteride/RU rotation and is basically cured as a dense NW1 with transplant?
distracted
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Did I miss something? Do you think they'll fail?
For example:
Intercytex failed cloning, the only thing I know is that they had some good results in their phase II trials but not what they expected in the phase III trials. But they had financial problems and they went under.
https://en.wikipedia.org/wiki/Hair_cloning
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distracted
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I'm familiar, but Swoops has always been advocating for Tsuji. I was surprised to hear him say that. His signature even says, 'predicts that Dr. Tsuji will be the first one to induce brand new hair follicles in humans.'
It's possible he meant "if Tsuji fails" not when?
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Given the current situation, yes I consider myself "cured". I'm content with my hair now and nobody would say I'm balding whatsoever. But I'm far from a dense NW1 guy with a hair transplant. I can't afford to lose much more hair to be honest because I lost a lot already. It's just that at this moment I have enough to work with.
That being said do remember that I'm very reliant on treatments and that Androgenetic Alopecia is a progressive condition. Without treatments I would be a NW6 pretty quick. Also, I haven't even hit 30's yet.
At this moment all I'm doing is "buying" time, but believe me that this time will run out eventually. It's still an ongoing battle and I would like it too stop. As I'll get older the battle will only get harder, and like I said I refuse to adopt a hardcore anti-androgen regime. Something like Tsuji his method would allow for the battle to be stopped "once and for all".
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I don't think they'll fail. I personally give them like a 80% chance to succeed given that they are able to culture those cells correctly.
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isnt this what your on right now?
do you mean you dont wana use finasteride/ru long term?
me too, no matter how much money I should throw into it. So, let's keep in touch.
If all else fails, I really hope some deregulated nation would become a gene therapy heaven. Money-wise this is realistic, unless some stupid market agreements with "civilized" nations would come into place to stop it.
But, still, imho we need cloning to restore bald areas, or or stem cells therapies to keep transplanted follicles alive for 10s of years (my case).
btw, @Swoop, any reason to doubt about Tsuji / Lauster / Replicel, or is it just a bad hair day?
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Does that mean that for you, transplanted hairs are actually thinning after a long long time?
Do you think this is normal/common with transplants? I noticed quite some people claiming similar things (transplanted hair falling out/thinning over time).
some of them; but it's a complex subject; I've posted what I know here:
https://www.gourmetstylewellness.com/intera...ng-stem-cell-therapies-on-transplants.103714/
