Propecia & Penis Shrinkage
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Deaner said:
That's a good point Deaner.
From the brief research I have made, I just got the feeling that Propecia is still a very "immature" drug. I have read of 1/3 year testing before the release of the drug, which isn't really that long. Another thing I would like to point out, is the ambiguousness of every thing concerning long term use of finasteride. Due to the relative youth of the drug, there isn’t any solid evidence that the secondary effects to do produce definitive damage.
lossing my hair
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i have an advise to those that are these negative thoughts on finasteride or lack of trust on finasteride to the point that it makes you paranoid. don't take the drug so theres nothing to worry about.
Deaner
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Plus, the study was in rats. How much shrinkage are we talking? And don't forget to take into account the dosages. I'm pretty sure they were injecting rats with obscene amounts of the drug, especially for their body size, in most of the studies they did. Also, don't forget that many men have been taking 5mg daily for a decade or so now. How many of them are bitching and complaining about penis shrinkage? Just a few things to think about before you go spreading more fear about finasteride...
hairschmair
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the amount of horseshit that flies around on this site is astounding. "1/3 year of testing for finasteride"
Expressing concern does not necessarily mean one is spreading fear of panicking.
Now, if you think that there is no reason for concern, then you are just being obtuse.
http://www.propeciasideeffects.com
Now, if you think that there is no reason for concern, then you are just being obtuse.
http://www.propeciasideeffects.com
Deaner
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I just think that your admittedly "brief researching", something many people on this forum alone have done in the past, is not grounds for a post that is quite obviously frightening for those less informed. You should very well know by now that a post like this, one that is mostly unsubstantiated and ill-researched, will raise red flags for those new to hairloss and the drugs involved, and those who haven't been dealing with (and subsequently countering) fear-inducing posts like this for months. The topic alone is enough to cause panic.
I understand what you are saying, but this board is not a scientific panel.
The ambiguousness of Propecia and most Hair loss medications themselves contradict this factual precision you so correctly oblige.
Propecia does not guarantee results, Propecia does not completely substantiate the side effects.
Other then that, I appologize for the "rudness" of the thread title.
The ambiguousness of Propecia and most Hair loss medications themselves contradict this factual precision you so correctly oblige.
Propecia does not guarantee results, Propecia does not completely substantiate the side effects.
Other then that, I appologize for the "rudness" of the thread title.
http://www.hairlosshelp.com/qna/Detail. ... ExpertID=1
Dr. Proctor
"I have seen sexual side-effects in Patients on finasteride and suspect that the incidence is higher than the 2-3% or so claimed by Merck. But in any case, it is likely significantly less than 10% or so. As for reversibility-- again, in my experience these reverse within a few weeks to a month or so after stopping treatment. And yes, I too have heard reports of long-term persistence of things like libido decreases, etc.. I do no know what to think about these. As for stopping--- like other antiandrogens, finasteride induces "reflex hyperandrogenicity", a combination of increased androgen receptors plus higher testosterone levels. For this reason I suggest tapering off treatment rather than stopping it abruply, if possible".
http://www.hairlosshelp.com/html/Propecia5yrstudy.cfm
Dr Lee
"I have never agreed with Merck's report of the incidence of side effects due to initial Propecia use. My experience with finasteride is that the percentage of patients with side effects of decreased libido, erectile dysfunction and/or ejaculatory disorder is approximately 5 or 6 times higher than the 3.8% that Merck reports. Initially, Merck claimed that the incidence of side effects was less than 2%. Since assessing 'decreased libido' is of such a subjective nature, I have repeatedly asked for a copy of Merck's original clinical trials. On each occasion, I've been denied a copy of that study. It is not surprising that the incidence of side effects declined dramatically in the fifth year of use. Patients who did have sexual side effects simply wouldn't tolerate those side effects for five years. With this in mind, the report of 0.6% of Propecia users having sexual side effects after five years of use sounds incorrect and misleading".
Dr. Proctor
"I have seen sexual side-effects in Patients on finasteride and suspect that the incidence is higher than the 2-3% or so claimed by Merck. But in any case, it is likely significantly less than 10% or so. As for reversibility-- again, in my experience these reverse within a few weeks to a month or so after stopping treatment. And yes, I too have heard reports of long-term persistence of things like libido decreases, etc.. I do no know what to think about these. As for stopping--- like other antiandrogens, finasteride induces "reflex hyperandrogenicity", a combination of increased androgen receptors plus higher testosterone levels. For this reason I suggest tapering off treatment rather than stopping it abruply, if possible".
http://www.hairlosshelp.com/html/Propecia5yrstudy.cfm
Dr Lee
"I have never agreed with Merck's report of the incidence of side effects due to initial Propecia use. My experience with finasteride is that the percentage of patients with side effects of decreased libido, erectile dysfunction and/or ejaculatory disorder is approximately 5 or 6 times higher than the 3.8% that Merck reports. Initially, Merck claimed that the incidence of side effects was less than 2%. Since assessing 'decreased libido' is of such a subjective nature, I have repeatedly asked for a copy of Merck's original clinical trials. On each occasion, I've been denied a copy of that study. It is not surprising that the incidence of side effects declined dramatically in the fifth year of use. Patients who did have sexual side effects simply wouldn't tolerate those side effects for five years. With this in mind, the report of 0.6% of Propecia users having sexual side effects after five years of use sounds incorrect and misleading".
hairschmair
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Okay, let's put this to rest.
I have not heard of one report, EVER, of penis shrinkage due to finasteride, and millions of people use it every day (if you count proscar). Once we get some reports then we can continue this silly discussion. Cool?
I have not heard of one report, EVER, of penis shrinkage due to finasteride, and millions of people use it every day (if you count proscar). Once we get some reports then we can continue this silly discussion. Cool?
hairschmair
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"I measured my penis the day I started finasteride and it was 6.0 inches, now X months later it is 5.0 inches"
Right here on gourmetstylewellness.com.
Right here on gourmetstylewellness.com.
hairschmair
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There's a thread a few days back entiteld "who has been on finasteride the longest on this site?" where some people have reported using it for 3-4-5 years. Why don't you go there and calm your fears by asking if anyone has noticed any 'shrinkage'.
Here is the study done on rats if anone is interested.
http://www.asiaandro.com/1008-682X/5/33.htm
Abstract
Aim: To investigate the ultrastructural changes of penile corpus cavernosum and tunica albuginea in rats treated with castration or finasteride. Methods: Eighteen male Sprague-Dawley rats of nine weeks old were randomly divided into three groups with 6 rats each. Group A served as the control, Group B was castrated and Group C, treated with finasteride. Four weeks later, rats were anesthetized and blood samples obtained for the determination of serum testosterone (T) and dihydrotestosterone (DHT) levels; penile tissues were taken for scanning electron microscopy.
Results: The T, free T and DHT levels in Group B and the DHT level in Group C were significantly lower than those in Group A (P<0.05). The tunica albuginea was significantly thinner in Group B than that in Group A (P<0.05), but there was no significant difference between Group C and Group A (P>0.05). Elastic fibers in the tunica albuginea of Group A were very rich and arranged regularly and undulatedly, but in Group B, most of the elastic fibers were replaced by collagenous fibers. In Group C, the tunica albuginea was mainly composed of thick and irregular-arranged collagenous fibers. In Group A, there were abundant smooth muscle fibers in the trabeculae of corpus cavernosum, but they were much less in Group C and scarce or even disappeared in Group B. In Groups B and C, the diminished/disappeared smooth muscle fibers were replaced by irregularly arranged collagenous fibers.
Conclusion: In rats, androgen is essential for maintaining the normal structure of penile tunica albuginea and corpus carvenosum.
http://www.asiaandro.com/1008-682X/5/33.htm
Abstract
Aim: To investigate the ultrastructural changes of penile corpus cavernosum and tunica albuginea in rats treated with castration or finasteride. Methods: Eighteen male Sprague-Dawley rats of nine weeks old were randomly divided into three groups with 6 rats each. Group A served as the control, Group B was castrated and Group C, treated with finasteride. Four weeks later, rats were anesthetized and blood samples obtained for the determination of serum testosterone (T) and dihydrotestosterone (DHT) levels; penile tissues were taken for scanning electron microscopy.
Results: The T, free T and DHT levels in Group B and the DHT level in Group C were significantly lower than those in Group A (P<0.05). The tunica albuginea was significantly thinner in Group B than that in Group A (P<0.05), but there was no significant difference between Group C and Group A (P>0.05). Elastic fibers in the tunica albuginea of Group A were very rich and arranged regularly and undulatedly, but in Group B, most of the elastic fibers were replaced by collagenous fibers. In Group C, the tunica albuginea was mainly composed of thick and irregular-arranged collagenous fibers. In Group A, there were abundant smooth muscle fibers in the trabeculae of corpus cavernosum, but they were much less in Group C and scarce or even disappeared in Group B. In Groups B and C, the diminished/disappeared smooth muscle fibers were replaced by irregularly arranged collagenous fibers.
Conclusion: In rats, androgen is essential for maintaining the normal structure of penile tunica albuginea and corpus carvenosum.