vogs said:
Vogs there probably are but I really don't know enough about the subject to make a good account of myself!
If you go to http://www.jurology.com (online journal of urology) then you may find some articles on the subject.
Propecia & Penis Shrinkage
- Thread starter vogs
- Start date
Vogs there probably are but I really don't know enough about the subject to make a good account of myself!
If you go to http://www.jurology.com (online journal of urology) then you may find some articles on the subject.
G
Guest
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maybe the fit female rat had ran away
Red Rose said:
Appreciate the resources mate.
Shame that the articles are so expensive, was looking foward to giving this one a good read: "The Effect of Testosterone on Androgen Receptors and Human Penile Growth.
Journal of Urology. 158(3):1113-1118, September 1997. "
The Gardener
Senior Member
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Or, maybe the p**rn they showed the rats on the second measurement wasn't as explicit as the first?
hairschmair
Established Member
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vogs said:
Show us a study and we'll take you seriously.
PS: You need to find one on DHT and penile growth, not Testosterone (as is the one you pointed out). Good Luck!
Effect of Androgens on Penile Tissue
Authors: Lewis Ronald W.; Mills Thomas M.
Source: Endocrine, March 2004, vol. 23, no. 2-3, pp. 101-106(6)
There are two ways to establish that androgens play a major role in the function and integrity of erectile tissue: (1) discussing a number of physiology and molec-ular biology studies that have been published from experiments in animals and (2) reporting the effect of androgens on penile tissue, or in many cases the lack of androgen, in man.
A variety of animal models, and also human studies, have shown the existence of androgen receptors in the corpora cavernosa. The penile erectile response in the laboratory rat is androgen dependent, and the active androgen appears to be dihydrotestosterone. There are several articles that describe the androgenic regulation of nitric oxide synthase (the enzyme responsible for production of nitric oxide), the primary agent controlling the erectile cycle.
There have been few reports showing a direct end organ dependency of androgen for erectile function in the human corpora cavernosa, although there is plenty of evidence demonstrating that low or absent androgens affect a man's ability to have an erection in a sexual situation. Thus, in man androgen dependency for cavernous tissue smooth muscle function is still debatable. Extrapolating animal dependency of androgens for molecular activity in the penile tissue remains the most reasonable suggestion for androgen dependency of the cavernous tissue in man.
Authors: Lewis Ronald W.; Mills Thomas M.
Source: Endocrine, March 2004, vol. 23, no. 2-3, pp. 101-106(6)
There are two ways to establish that androgens play a major role in the function and integrity of erectile tissue: (1) discussing a number of physiology and molec-ular biology studies that have been published from experiments in animals and (2) reporting the effect of androgens on penile tissue, or in many cases the lack of androgen, in man.
A variety of animal models, and also human studies, have shown the existence of androgen receptors in the corpora cavernosa. The penile erectile response in the laboratory rat is androgen dependent, and the active androgen appears to be dihydrotestosterone. There are several articles that describe the androgenic regulation of nitric oxide synthase (the enzyme responsible for production of nitric oxide), the primary agent controlling the erectile cycle.
There have been few reports showing a direct end organ dependency of androgen for erectile function in the human corpora cavernosa, although there is plenty of evidence demonstrating that low or absent androgens affect a man's ability to have an erection in a sexual situation. Thus, in man androgen dependency for cavernous tissue smooth muscle function is still debatable. Extrapolating animal dependency of androgens for molecular activity in the penile tissue remains the most reasonable suggestion for androgen dependency of the cavernous tissue in man.
Hairport
Member
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Anyone here on finasteride and do PE? That would directly relate to your penile tissue and it's ability to heal, etc. I have seen good gains from PE, but I am not on finasteride. Studies aside ... anyone here on propecia noticed their dick being in bad shape? The lasercomb made my dick grow three inches. 
An email extract between Dr. Lee and another user.
"Dr. Lee,
I recently came across this study:
http://www.asiaandro.com/1008-682X/5/33.htm
I was wondering if this is the reason why men on
finasteride sometimes have erection problems,
sometimes even for months or years after discontinuing
finasteride. Do you think this is likely?
Also, do you think that this is reversible?"
Dr. Lee's response:
"That is a fascinating study. The methodology is very scientific and
the work is entirely credible. How did you ever happen to access such an obscure article?
Just earlier today (and I apologize for the delayed reply to your
question), a patient had complaints about difficulty in achieving and maintaining an erection, although his libido was fine after discontinuing finasteride for two years. The findings from this study may be the explanation.
So, the direct answer to your question is "Yes". It may very well be
that the long term use of finasteride can cause microscopic harmful
structural changes in the erectile tissues of the penis.
We have to be very careful not to unthinkingly apply these results in
rats to humans, but the findings are potentially very alarming.
Thank you very much for calling my attention to this article.
If, in fact, the elastic tissue was replaced with collagenous tissue
and there was fibrosis in the tunica albuginea and in the corpus
cavernosum, the difficulty with erections may not be reversible.
Richard Lee, M.D."
"Dr. Lee,
I recently came across this study:
http://www.asiaandro.com/1008-682X/5/33.htm
I was wondering if this is the reason why men on
finasteride sometimes have erection problems,
sometimes even for months or years after discontinuing
finasteride. Do you think this is likely?
Also, do you think that this is reversible?"
Dr. Lee's response:
"That is a fascinating study. The methodology is very scientific and
the work is entirely credible. How did you ever happen to access such an obscure article?
Just earlier today (and I apologize for the delayed reply to your
question), a patient had complaints about difficulty in achieving and maintaining an erection, although his libido was fine after discontinuing finasteride for two years. The findings from this study may be the explanation.
So, the direct answer to your question is "Yes". It may very well be
that the long term use of finasteride can cause microscopic harmful
structural changes in the erectile tissues of the penis.
We have to be very careful not to unthinkingly apply these results in
rats to humans, but the findings are potentially very alarming.
Thank you very much for calling my attention to this article.
If, in fact, the elastic tissue was replaced with collagenous tissue
and there was fibrosis in the tunica albuginea and in the corpus
cavernosum, the difficulty with erections may not be reversible.
Richard Lee, M.D."
Hey guys.
Please comment on or correct the following speculative proposition:
Dutasteride would be no more likely than Finasteride to cause problems in the penis. Finasteride is already inhibiting 5AR type II enzyme active in the liver and sex organs; Dutasteride is merely doing what Finasteride is already doing in the liver and sex organs, PLUS inhibiting 5AR type I enzyme active in the brain and skin. Therefore, Dutasteride doesn't do anything in the sex organs that Finasteride isn't already doing; it's simply adding places of the body where there might be complications.
Does that sound right? Or is it ridiculous?
Please comment on or correct the following speculative proposition:
Dutasteride would be no more likely than Finasteride to cause problems in the penis. Finasteride is already inhibiting 5AR type II enzyme active in the liver and sex organs; Dutasteride is merely doing what Finasteride is already doing in the liver and sex organs, PLUS inhibiting 5AR type I enzyme active in the brain and skin. Therefore, Dutasteride doesn't do anything in the sex organs that Finasteride isn't already doing; it's simply adding places of the body where there might be complications.
Does that sound right? Or is it ridiculous?
Red Rose said:
Amazing... I wanted to bring this back up so others could see it.
I agree with the statement "We have to be very careful not to unthinkingly apply these results in
rats to humans, but the findings are potentially very alarming. " but it is interesting nonetheless
The Gardener
Senior Member
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Do you eat high-cholesterol foods? I wonder how the damage these foods do to you compares to the risk mentioned in the article?
I'm not discrediting the article, but just trying to add some perspective. In contradiction to the much earlier statement on this thread that finasteride is a 'young' drug, in fact it really isn't. It's been prescribed as Proscar for prostate problem sufferers much longer than its use as a hairloss treatment.
I'm not discrediting the article, but just trying to add some perspective. In contradiction to the much earlier statement on this thread that finasteride is a 'young' drug, in fact it really isn't. It's been prescribed as Proscar for prostate problem sufferers much longer than its use as a hairloss treatment.
too bald too furious
Experienced Member
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Scary post.
Can some veteran posters shed some light on this topic.
Bryan, gourmetstylewellness.com, Cassin?
Can some veteran posters shed some light on this topic.
Bryan, gourmetstylewellness.com, Cassin?
Cassin
Senior Member
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Good thing I don't have a rat penis. :lol:
It's just a matter of time now before we have posters claimng their weiners are shrinking sicne peopel have read this.
On a side note, Dr Lee really started becoming anit-finasteride around the time Xandrox %15 came out.
It's just a matter of time now before we have posters claimng their weiners are shrinking sicne peopel have read this.
On a side note, Dr Lee really started becoming anit-finasteride around the time Xandrox %15 came out.
Chris Johnson
Member
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Cassin, it's not like Dr. Lee has any finacial gain in Xandrox....oh, wait
On a serious note, do you guys think rubbing DHT cream on the rat penises would have helped? :lol:
On a serious note, do you guys think rubbing DHT cream on the rat penises would have helped? :lol: