stax said:
Okay, main question.
How can you call Dutasteride safe when:
1. It hasnt been FDA approved for hairloss
2. There are no studies showing what inhibiting type 1 5AR in the brain might do longterm. Im talking 10-15 years of studies and backgrounds like Finesteride. There is a biological model in humans for finesteride's action, but not Dutasterides. There might be unknown neuroligcal complications due to inhibiting type 1 5AR in the brain considering type 1 5AR prevents neurological toxicity by catabolism of neurotoxic steriods, and so forth.
3. over 50% of the drug's metabolites couldnt be accounted for in the body, like in urine, feces,ect. Where the heck does that 50% go?
1) You're right. It's not approved for hairloss. But, it's approved by the FDA to be safe for treating BPH, the same condition that Propecia, in higher doses, commonly prescribed as Proscar, is. The two drugs are "cousins" in a sense that they have similar mechanisms of action. Dutasteride has consistently been used by thousands, if not millions, of people around the world for treating their hairloss. Avodart, since its unveiling in late 2001, early 2002, has not accounted for any deaths, mental "complications," or any other conditions, except, of course, the side effects that come with the medicine and those who are allergic to the drug.
2) This is pure speculation, Stax. There's just no answer to this, although we DO know that Avodart has been proven safe in a 4-year study. All indications seem to show that Avodart will continue to be safe going on 10 years, yes?
3) Wow. Way to misconstrue figures. I believe your "over 50%" is somewhere around 40%.
Although we cannot prove that the mechanism of dutasteride to be safe, (type 1), we have substantial evidence showing that, in practice, it is.
Here's a crapload of studies done, showing that dutasteride has been proven safe within the many years it's been on the market:
http://www.dutasteride.org/dutasteride/ ... tudies.htm
Yes, some of the studies go as far as to say that these men are "healthy," countering your notion that the only men tested were not "healthy."
In my own conclusion, at the end of the day, dutasteride has NOT been proven to be NOT safe... but it has been proven to be safe, over and over again, in multiple studies, and large FDA clinical trials.
Use at your own risk, with supervision of a doctor.
Stax, the users are aware that you yourself take dutasteride, despite all of these large, terminal risks you suggest.