Regimen update - long time dutasteride/RU user

[Pls_NW-1]

A man´s rule is to not touch opposite sex hormones lol.
Never do that just for hair loss, not worth it, too many (side) effects for a cis male. But sure, it will restore your hair like magic.

2mg E2
50mg Bicalutamide
5mg Minoxidil
1mg Finasteride

Thats your magic hair cocktail, if you don't mind side effects.

 

[Avacado]

This whole idea of using estrogen in any way really sucks, not a position wanted to be in.

 

[Avacado]

Well, I'm defn. adding another AA ASAP, it's just a matter of what. I guess my options are Bicalutamide or ORM.

 

[ElToso]

@ElToso when you used 1mg of estone, was that in pill form or some other mechanism? Curious if that's an option for me...

Lotion

 

[Isneezedsohard]

A man´s rule is to not touch opposite sex hormones lol.
Never do that just for hair loss, not worth it, too many (side) effects for a cis male. But sure, it will restore your hair like magic.

Even at 1mg dose topical?

 

[Pls_NW-1]

Well, I'm defn. adding another AA ASAP, it's just a matter of what. I guess my options are Bicalutamide or ORM.

topical dont work really in my eyes as efficient as orals. AR signaling happens as well in the fat cells in the underlying tissue. Follicles are connected to the blood flow. Topicals... just dont make sense to me. It would be amazing if we would get in near future great drugs, which affect Androgen receptors, when taken orally, only in scalp tissue, like we have now with estrogen receptors for delaying breast growth aka. ralox, tamox. But... that wont happen anytime soon lol. Maybe we will get a good AR degrader in 5-10 years (PROTAC-Drugs) for topical use with a low molecule size to properly be absorbed, but not systemically.

I think Bicalutamide is the "safest" amongs the worst AA drugs lol. Some say it is great, even for long term use, some say that you shouldnt use AAs more than 90 days.

 

[Pls_NW-1]

This whole idea of using estrogen in any way really sucks, not a position wanted to be in.

Another thing, when you take Bicalutamide, you won't be in need to take estrogens, as bicalutamide increases your sex hormones, but stops androgen/male hormones to work in the body. I do wonder what the health-related effects are of androgen deprivation therapy. Some studies show it as a "Quality of Life; drug", and some say it is hepatotoxic or even, it can hurt the heart. Tho, I do think that Bicalutamide is safe, due to it's low binding affinity. The blockage of the AR signaling by Bicalutamide depends on the concentration of itself and the concentration of androgens. Peripheral tissues (skin, outer regions) have lesser androgen concentration, in relation to the testicles, bones or muscles. No wonder why Bicalutamide has no effect on testicles, bones and muscles.

BUT I ALARM YOU! This drug is taken for advanced prostate cancer patients, who don't have to choose, because their lives depends on it!
I don't have the permission to give medical advice, nor others. Keep your own research and evaluate between risk-benefit scale.

 

[Pls_NW-1]

Even at 1mg dose topical?

Yes! Never touch estrogens! Unless you are ok with estrogenic effects. at 2mg it is possible that your T production gets reduced to high female ranges (not healthy for a male´s (sex) life lol)

Topicals, clicks etc. go systemic, there is no need for that hassle, rather pop up some pills, bucally, sublingually, swallowed idk.

 

[Doingitright]

I've been struggling with sexual sides for a few years now, but I think that's more due to the Avodart. I've been using Cialis which works like a champ, but even that is starting to fade a bit.

Have you had some bloods done?

 

[Avacado]

Another thing, when you take Bicalutamide, you won't be in need to take estrogens, as bicalutamide increases your sex hormones, but stops androgen/male hormones to work in the body. I do wonder what the health-related effects are of androgen deprivation therapy. Some studies show it as a "Quality of Life; drug", and some say it is hepatotoxic or even, it can hurt the heart. Tho, I do think that Bicalutamide is safe, due to it's low binding affinity. The blockage of the AR signaling by Bicalutamide depends on the concentration of itself and the concentration of androgens. Peripheral tissues (skin, outer regions) have lesser androgen concentration, as like the testicles, bones or muscles. No wonder why Bicalutamide has no effect on testicles, bones and muscles.

BUT I ALARM YOU! This drug is taken for advanced prostate cancer patients, who don't have to choose, because their lives depends on it!
I don't have the permission to give medical advice, nor others. Keep your own research and evaluate between risk-benefit scale.

I don't know, I was just reading about Bicalutamide and it kind of scares me a bit now. I would like to explore ORM, problem is I've never heard of it before until the other day when @AndrewBarnes started talking about it. Realistically, what other options do I have besides another AA.

 

[Avacado]

Have you had some bloods done?

No, never have.

 

[Doingitright]

No, never have.

Hmm I think first you should get some bloods done and get you thyroids checked, may not be entirely male pattern baldness. You could be adding to the wrong arsenal.

 

[Doingitright]

No, never have.

What is your hair loss pattern like and how are your nails and general fat composition? energy levels good? achy joints at all?

 

[Pls_NW-1]

I don't know, I was just reading about Bicalutamide and it kind of scares me a bit now. I would like to explore ORM, problem is I've never heard of it before until the other day when @AndrewBarnes started talking about it. Realistically, what other options do I have besides another AA.

Nothing. As of now.

1.) Bicalutamide (high doses, depends on your basline T levles, and after 3 months, T levels)
2.) E2 + Bicalutamide (low dose)
3.) E2 (high doses)
4.) Bicalutamide + Finasteride
5.) Dutasteride + ORM/Darolutamide (topical) (+ Estriol (topical))
6.) shaving, being bald.
7.) HairSystem.

 

[Avacado]

Nothing. As of now.

1.) Bicalutamide (high doses, depends on your basline T levles, and after 3 months, T levels)
2.) E2 + Bicalutamide (low dose)
3.) E2 (high doses)
4.) Bicalutamide + Finasteride
5.) Dutasteride + ORM/Darolutamide (topical) (+ Estriol (topical))
6.) shaving, being bald.
7.) HairSystem.

Is ORM/Darolutamide the same thing, if not do they need to be taken together or something? I'm trying to find what the right daily dosage of that would be. I'm staying away from all Estrogen related crap, and would prefer to stay away from Bicalutamide.

 

[Isneezedsohard]

Yes! Never touch estrogens! Unless you are ok with estrogenic effects. at 2mg it is possible that your T production gets reduced to high female ranges (not healthy for a male´s (sex) life lol)

Topicals, clicks etc. go systemic, there is no need for that hassle, rather pop up some pills, bucally, sublingually, swallowed idk.

Jeez sh*t ok

 

[Pls_NW-1]

If you choose for Bicalutamide, it will give you a neotenic appearence, you will keep sexual function, have gyno and no sperm production while using it.

If you choose for Estrogens, you enter the Hormonal route of transitioning into (half) female.

If you take the topical route, you might have success, and not much systemical side effects, but not guaranteed that it works, as for many, ORM just didnt work, only just for exceptions, I already told you, oral is way more effective.

Hair Systems will be without side effects etc. but costly and not really handy, depends on the person.

 

[Isneezedsohard]

If you choose for Bicalutamide, it will give you a neotenic appearence, you will keep sexual function, have gyno and no sperm production while using it.

If you choose for Estrogens, you enter the Hormonal route of transitioning into (half) female.

If you take the topical route, you might have success, and not much systemical side effects, but not guaranteed that it works, as for many, ORM just didnt work, only just for exceptions, I already told you, oral is way more effective.

Hair Systems will be without side effects etc. but costly and not really handy, depends on the person.

I hate the idea of systems.

 

[Pls_NW-1]

Is ORM/Darolutamide the same thing, if not do they need to be taken together or something? I'm trying to find what the right daily dosage of that would be. I'm staying away from all Estrogen related crap, and would prefer to stay away from Bicalutamide.

ORM is the metabolite of Darolutamide (ODM).

ODM will be metabolized in the body to ORM. Because of that the drug is longer in your body -> higher rate for side effects.

When taken the metabolite, half-time is shorter. Guess that clarifies.

 

[Pls_NW-1]

I hate the idea of systems.

Same.