Replicel Hair Loss Treatment Trial Is Set To Begin In Japan

[Greybeer]

OK so I was correct, and stuff like that can only be done in Japan, and it doesn't necessarily apply to drugs? Only cells based therapies

 

[Blackber]

I don't know I would use the word "supposing" because I'm not just saying that some researchers have presented misinformation and lies, I'm also saying that Replicel researchers have already said something fishy. They are blaming the hair loss of some of their test subjects on "shock loss" which sounds fishy. Plus I'm also aware that they got poor hair growth results in their first study. You can find those study results on the internet if you care to look for them.

Phase 1 was for efficacy at lower dosing, not sure why you're making such a big deal about there lack of results.

It would obviously be great if they got great adults right off the bat but until I see Phase 2 results I wouldn't pay any mind to Phase 1.

And every researcher is going to do anything they can to make their results better than they are. Something we do when we style our hair a certain way to hide our hair loss. I'm not saying what researchers do is moral but it's the name of the game.

 

[Mister_you]

When do you guys think they'll release the phase 2 results?

 

[Greybeer]

The one picture that they have released, did show significant thickening of hairs, there is not even a slight argument there to make one is blatant stupidity far beyond cynicism. Not as much regrowth as we want but there was some ( there could be a slight argument there, but according to my eyes 100% there is some small regrowth sure as hell better than minoxidil)! Considering that was likely a phase I patient it should do better in the phase II theoretically. However there's nothing concrete about more being better when it comes to stem cells,it seems to be more about finding the perfect dose and mechanism

 

[pegasus2]

When do you guys think they'll release the phase 2 results?

Not until they are making the treatment available. Hopefully 2018.

 

[Blackber]

When do you guys think they'll release the phase 2 results?

Phase2 just started and is slated to last 3 years.

If they see good results I'd imagine they'd release something before the phase trial ends and try to bring the product to market.

 

[Greybeer]

Not until they are making the treatment available. Hopefully 2018.

I really hope so, but guys I encourage you not to get your hopes up about the date. In every single clinical trial involving stem cells (mind you the conditions I've been following intensively are much more severe) always go far beyond their deadline or estimated release. I mean after a groundbreaking phase 2 was complete we waited over a year for a simple publication, and the results were far from staggering. The phase 2 is also the critical point, not necessarily when they run out of money but actually when they decide whether or not their product is worth moving forward With, after a phase 1 they really are not 100% conclusive, they know itis most likely safe to a certain extent, but they are not by any means 100% confident in itsefficiency which is what phase 2 is designed to determined. You can't always get excited by their reactions or showboating they do in interviews at this point, they want people to be investing in this they want people to be excited for it.

Having said all that my only hope with the timeline is the Japanese stem cell regulations, very different from most other countries! If it wasn't for this factor, I would guarantee you, in fact I'd bet everything I havethat it would not be available in 2018. And I would win that bet. But this isn't North America, this is Japan like I said different regulations

 

[NewUser]

Still don't like the fact that they're only using 60 patients.

More patients would be nice, I agree. But apparently people are just not volunteering to be test patients for any new drug or cell-based therapies in numbers considered ideal. I also agree with the previous poster who explained that Replicel will simply be looking for a large effect, and 60 test patients would serve that purpose.

 

[pegasus2]

More patients would be nice, I agree. But apparently people are just not volunteering to be test patients for any new drug or cell-based therapies in numbers considered ideal. I also agree with the previous poster who explained that Replicel will simply be looking for a large effect, and 60 test patients would serve that purpose.

It isn't a question of lack of funds, so they must be confident in a large effect. I'd love to see a larger trial, but this could be a good sign.

 

[That Guy]

Yeah, it'd be nice if there were more than sixty, but I only give a sh*t if it works at least the majority of the time and I can get shot up with it STAT

 

[thomps1523]

I do wish more forum members would quit trying to show how long they've been searching for a cure, so they're basically pros at understanding how it all works, and reminding everyone to temper their expectations... Most get it, it's not like hair loss is the only area of medicine that experiences delays of some sort... We're hopeful, so let us be hopeful!

 

[Pray The Bald Away]

I do wish more forum members would quit trying to show how long they've been searching for a cure, so they're basically pros at understanding how it all works, and reminding everyone to temper their expectations... Most get it, it's not like hair loss is the only area of medicine that experiences delays of some sort... We're hopeful, so let us be hopeful!

This forum is full of concern trolls.

 

[That Guy]

I do wish more forum members would quit trying to show how long they've been searching for a cure, so they're basically pros at understanding how it all works, and reminding everyone to temper their expectations... Most get it, it's not like hair loss is the only area of medicine that experiences delays of some sort... We're hopeful, so let us be hopeful!

I feel sorry for the naysayers and nihilists, I think most are victims of many many years of disappointment.

In fairness, up until the last decade, most researchers have obviously been looking in the wrong place. If the science proves anything, it's that the only way this disease will be remedied, is with cells. I just don't think that magical topical ointment that regrows all your lost hair everyone is waiting for is ever going to be a thing.

But that's what people had been saying "In the next five years" about for centuries. So naturally, when companies like Shiseido and Riken come along and say "We think we can have this out by 2020 or 2018", it sounds like the same old story despite having actual scientific ground. If Riken succeeds in releasing their treatment in 2020, you'll have people in 2019 who were reminding you of how long they've been searching for a cure and it will be "decades" more yet.

 

[mr_robot]

In fairness, up until the last decade, most researchers have obviously been looking in the wrong place. If the science proves anything, it's that the only way this disease will be remedied, is with cells. I just don't think that magical topical ointment that regrows all your lost hair everyone is waiting for is ever going to be a thing.

The problem is it is actually seems easier to work with stem cells to recreate follicles rather than actually figure out the why and mechanics behind balding. All the treatments being worked on so far either relies on blocking AR related activity or incouraging new cell profiliation via stimulation. You would probably need something like a 15year study taking biopsies at regular intervals on people with a large enough set of people to catch all the different types for hair loss to even get an idea, so it's basically never going to happen as hair loss however much it affects people is just not that important in the medical world.

We will get there in the end but if you're in your 20's hoping for relief real soon I would n't get my hopes up, the good news is that you'ill probably will have something in your 30's which is still young and I'm saying this as someone who has reached 40.

 

[That Guy]

The problem is it is actually seems easier to work with stem cells to recreate follicles rather than actually figure out the why and mechanics behind balding. All the treatments being worked on so far either relies on blocking AR related activity or incouraging new cell profiliation via stimulation. You would probably need something like a 15year study taking biopsies at regular intervals on people with a large enough set of people to catch all the different types for hair loss to even get an idea, so it's basically never going to happen as hair loss however much it affects people is just not that important in the medical world.

We will get there in the end but if you're in your 20's hoping for relief real soon I would n't get my hopes up, the good news is that you'ill probably will have something in your 30's which is still young and I'm saying this as someone who has reached 40.

I'll be 27 going on 28 in the year 2020, which is Tsuji's best case scenario and two years after Shiseido's. I got to really enjoy the first 3 years of my 20s, despite all the bad stuff going on in my life at the time. However, I've come to terms with the fact that the rest of my 20s are a write-off.

As a teenager, I had really long hair and didn't care much about my appearance. So, at age 19-20, I cut it shorter and just gave more of a sh*t.

This taught me that appearances, hair specifically, matters. I went from getting accosted by cops, asked if I sold drugs, etc. to "you're hired" at every job interview, being approached by potential new friends all the time and was successful with the kinds of women I previously could only lust over. Fast forward to now and I'm a NW3 before I realized what was happening. Hairloss both sped up and turned back time for me. Now, "Oh, sorry, I thought you were a lot older" and I'm back to pretty much getting the same rejection as younger me did.

The pressure is on these companies, and I do think they realize it, to put this problem in its grave soon. If you think the world is superficial in the era of Facebook and Tinder, it's going to be child's play compared to the next few years, which will bring about the internet of things. First impressions are really going to be everything and if you're in your teens to 30s, bald(ing) is going to be your death knell.

To those who won't be able to afford or simply choose to remain bald when these therapies are commercialized...pick a god and pray that he will have mercy on your soul, because society won't.

 

[bags]

I'll be 27 going on 28 in the year 2020, which is Tsuji's best case scenario and two years after Shiseido's. I got to really enjoy the first 3 years of my 20s, despite all the bad stuff going on in my life at the time. However, I've come to terms with the fact that the rest of my 20s are a write-off.

As a teenager, I had really long hair and didn't care much about my appearance. So, at age 19-20, I cut it shorter and just gave more of a sh*t.

This taught me that appearances, hair specifically, matters. I went from getting accosted by cops, asked if I sold drugs, etc. to "you're hired" at every job interview, being approached by potential new friends all the time and was successful with the kinds of women I previously could only lust over. Fast forward to now and I'm a NW3 before I realized what was happening. Hairloss both sped up and turned back time for me. Now, "Oh, sorry, I thought you were a lot older" and I'm back to pretty much getting the same rejection as younger me did.

The pressure is on these companies, and I do think they realize it, to put this problem in its grave soon. If you think the world is superficial in the era of Facebook and Tinder, it's going to be child's play compared to the next few years, which will bring about the internet of things. First impressions are really going to be everything and if you're in your teens to 30s, bald(ing) is going to be your death knell.

To those who won't be able to afford or simply choose to remain bald when these therapies are commercialized...pick a god and pray that he will have mercy on your soul, because society won't.

Don't worry. Soon you'll be able to configure your Avatar to look like Brad Pitt in Fight Club. Soon we will all be living in VR lol. I don't believe in Nhilism but I also think all the progress and technology is driving humanity into the shitter. Unless progress is moving in the direction of cures for diseases and people coming to a higher understanding of existance we are fast moving towards a global Japanese society. No economic growth (contraction infact). No new children being born. Everyone has a digital Bf/Gf or Spouse. No one interacts with one another anymore...... By 2020 we will be able to buy ourselves a Stepford Wife lmao. Buy a whole gang of em. Have 10 humanoid partners who don't eat, sh*t, complain, have morning breath etc lmao haha...... FML what is life? I'm just hear to have a good time not a long time. I feel good for those who will never have to deal with balding. But I can't imagine the crap they are going to have to deal with in the world.

 

[That Guy]

 

[nameless]

You're going to fly to Japan for a treatment that was tested on 20-30 people (remember, everyone doesn't get the experimental arm)? If it's overwhelming and works for like 99% of the patients, I'll be excited. Anything less and it's not gonna look good, especially with such a small sample.

The small number of test subjects is disturbing.

Why would they do that?

 

[That Guy]

The small number of test subjects is disturbing.

Why would they do that?

This is just my theory, but a possible explanation is that this is essentially a surgery and not a drug. It either works or it doesn't.

With something like drugs, it always stands to reason that people's' bodies respond to medication differently for a whole host of reasons. Genetics, allergies, existing conditions etc. can determine whether or not you'll see good results, no effect or outright immunity. In such a case, you want a huge sample group to account for as many differences as you can.

Something like a blood transfusion or other surgery shouldn't matter whether you tried it on 60 people or 60,000. You should see a high success rate. Because if the procedure fails, it should be because the surgery was applied incorrectly or some other medical condition inhibited it.

 

[jc3303]

I've been wondering lately if you first get follica treatment then go and get replicel could it greatly improve results?

I mean follica can produce 25 terminal hairs per cm^2 plus 75 vellus, hopefully replicel could immunize the terminal hairs and possibly force some vellus hairs to become immune terminal hairs. that would be a huge improvement for anyone