Revita vs Tricomin vs Nizoral??

[striker9]

Some say folligen is a scam.

But i think it doesn't work for all people the same way.

I'm starting with tricomin now.

 

[BoilerRoom]

Dr. Proctor,
Since both Tricomin and NANO are SOD'es, and NANO is presumably a more stronger SOD, would hairs that were grown due to Tricomin be maintained with NANO?

NANO is a pyridine-N-Oxide hair growth stimulator. We don't know exactly how it works, but it is not an SOD that we know of, though it is possible that it gets converted metabolically to one..

Peter H. Proctor, PhD,MD

Dr. Proctor,

Didn't you develop pyridine-N-Oxide as Minoxidil-type stimulant based on the assumption that Minoxidil is a vasodilator?? I believe you stated that in the past.

However, recent studies have shown that Minoxidil's effects have nothing to do with vasodilation.

So, now your saying you developed pyridine-N-Oxide with no idea how it works? That seems a little suspicious.

For the record, I purchase prox-n but not for the P-N-O. I have the feeling it's a cheap ingredient to manufacture. I wish you'd base Prox-n more so on Cu/Zn peptides, which have been shown to reverse fibrosis.

 

[pproctor]

Dr. Proctor,

Didn't you develop pyridine-N-Oxide as Minoxidil-type stimulant based on the assumption that Minoxidil is a vasodilator?? I believe you stated that in the past.

However, recent studies have shown that Minoxidil's effects have nothing to do with vasodilation.

So, now your saying you developed pyridine-N-Oxide with no idea how it works? That seems a little suspicious.

For the record, I purchase prox-n but not for the P-N-O. I have the feeling it's a cheap ingredient to manufacture. I wish you'd base Prox-n more so on Cu/Zn peptides, which have been shown to reverse fibrosis.

You are preaching to the choir. In fact, you are quoting things at me that I discovered and published in the first place. How soon people forget...

BTW, we do not use PNO per se. PROX-N includes NANO, a derivative.

Actually, I have never thought that minoxidil works because it is a vasodialator. In fact, nobody has thought this for a long time. For one thing, there are many vasodialators that don't grow hair. And NO-containing hair growth stimulators that do not dialate blood vessels.

Rather, minoxidil (or perhaps a metabolite) stimulates hair growth and dialates blood vessels because it is a "nitric oxide agonist". That is , it acts like NO, probably on "K-channels".

Nitric oxide ("NO") does a lot of things. Two of these happen to be 1) directly modulating the hair cycle and 2) dialating blood vessels. So minoxidil does both too. But these actions are independent of one another.

BTW, I published a paper on all of this in Archives of Dermatology roughly 20 years ago. The same with the antifibrotic effects of SOD's and SOD-mimetics such as the blue copper peptides, TEMPOL, etc. In fact, I hold the original patents on all of this stuff.

Interestingly, we were using SOD itself to prevent interocular fibrosis in experimental animals in the mid-1970's. Works pretty well too.

Part at least of the antifibrotic effect of SOD's appears to involve the reversion of mature scar cells (myofibroblasts) to their precurser cells (fibroblasts).

As for copper peptides-- I own the primary patents. So I don't need to be reminded of their efficacy. Yes they do work.

However, more recently, I have come to beleive that another class of SOD-mimetics, the nitroxide spin labels such as TEMPOL may work somewhat better. So we are now adding more of these, while still retaining the copper peptides. Every bit helps here.

As for NANO--- like minoxidil, TEMPOL, and PBN, it is technically also an N-Oxide, though the arrangement of electrons around the NO-group is a little different in all these compounds. Its mechanism of action may be like any of these or none of them. One thing does seem to be clear-- NANO is not a vasodiatator, or at least not much of one.

Peter H. Proctor, PhD,MD

 

[Petchsky]

Dr Proctor, since you're here, what's your opinion on PRP injections? (plasma rich platelets)

 

[BoilerRoom]

You are preaching to the choir. In fact, you are quoting things at me that I discovered and published in the first place. How soon people forget...

BTW, we do not use PNO per se. PROX-N includes NANO, a derivative.

Actually, I have never thought that minoxidil works because it is a vasodialator. In fact, nobody has thought this for a long time. For one thing, there are many vasodialators that don't grow hair. And NO-containing hair growth stimulators that do not dialate blood vessels.

Rather, minoxidil (or perhaps a metabolite) stimulates hair growth and dialates blood vessels because it is a "nitric oxide agonist". That is , it acts like NO, probably on "K-channels".

Nitric oxide ("NO") does a lot of things. Two of these happen to be 1) directly modulating the hair cycle and 2) dialating blood vessels. So minoxidil does both too. But these actions are independent of one another.

BTW, I published a paper on all of this in Archives of Dermatology roughly 20 years ago. The same with the antifibrotic effects of SOD's and SOD-mimetics such as the blue copper peptides, TEMPOL, etc. In fact, I hold the original patents on all of this stuff.

Interestingly, we were using SOD itself to prevent interocular fibrosis in experimental animals in the mid-1970's. Works pretty well too.

Part at least of the antifibrotic effect of SOD's appears to involve the reversion of mature scar cells (myofibroblasts) to their precurser cells (fibroblasts).

As for copper peptides-- I own the primary patents. So I don't need to be reminded of their efficacy. Yes they do work.

However, more recently, I have come to beleive that another class of SOD-mimetics, the nitroxide spin labels such as TEMPOL may work somewhat better. So we are now adding more of these, while still retaining the copper peptides. Every bit helps here.

As for NANO--- like minoxidil, TEMPOL, and PBN, it is technically also an N-Oxide, though the arrangement of electrons around the NO-group is a little different in all these compounds. Its mechanism of action may be like any of these or none of them. One thing does seem to be clear-- NANO is not a vasodiatator, or at least not much of one.

Peter H. Proctor, PhD,MD

Thanks for your time. It's great having you on this board.

I'm still fascinated in the ability of SODs to reverse fibrosis.

 

[pproctor]

Dr Proctor, since you're here, what's your opinion on PRP injections? (plasma rich platelets)

Most likely, you mean "platelet rich plasma". Never heard of this being used for treatment of hair loss. Mostly, it is for diseases where platelets may be short, such as after chemotherapy.

A caution: I would not take any blood product unless I really needed it. Certainly not for a cosmetic purpose, unless it was my own blood, naturally. Too much hazard.

Peter H Proctor, PhD,MD

 

[pproctor]

I'm still fascinated in the ability of SODs to reverse fibrosis.

For more on this, go to http://www.pubmed.gov and use "fibrosis" and "superoxide" as keywords. Superoxide seems to be a major messenger for turning on fibrosis (scarring), as well as a lot of other things. I first reported this at a scientific meeting in 1979, he says modestly. See http://www.redoxsignaling.com .

The significance of this with respect to pattern hair loss is that fibrosis seems to be a significant terminal event in the balding process. You can see it under the microscope.

Peter H. Proctor, PhD,MD

 

[LosingTouch]

Ok ok ok, so.. NANO or Tricomin?

:newbie:

 

[pproctor]

Ok ok ok, so.. NANO or Tricomin?

:newbie:

Shame-less plug: I hold the primary patent (abstract below) on SOD-mimetic drugs such as Trichomin. We include these along with NANO ( which is a completely-different class of hair-loss-treatment agents ) and other agents in our formulations. So you get the advantages of all of our technology, not just that of the copper peptides.

Peter H Proctor, PhD,MD
__________________________________

United States Patent 5,470,876
Proctor Nov. 28, 1995

Topical sod for treating hair loss

Inventors: Proctor; Peter H. Appl. No.: 229,374
Filed: Apr. 18, 1994

Abstract

SOD for treating hair loss is disclosed. The SOD has utility in a topical pharmaceutical formulation for the cosmetic treatment of hair loss and the cosmetic stimulation of hair growth. The SOD comprises copper salicylate, copper aspirinate, indomethacin-copper, or a complex of an amino acid or peptide and a transition metal.

 

[LosingTouch]

thanks, SOD it is! Does the treatment work in similar ways where by if you are to stop using it after a period of time the gains from that period will disappear? Also, best regarded agent to buy from?

 

[pproctor]

thanks, SOD it is! Does the treatment work in similar ways where by if you are to stop using it after a period of time the gains from that period will disappear? Also, best regarded agent to buy from?

Yes, if you stop using an SOD, you will lose what you have gained. As for which to use-- ours, naturally.

Remember, we own the primary patents and can use what we think is best. If there were anything else that worked better, we would be using that too.

Dr Proctor

 

[LosingTouch]

Cool, so do you have a website I can buy it through?

 

[pproctor]

Cool, so do you have a website I can buy it through?

We do. But our generous host does not approve of commercial internet addresses being posted here. Use my name as a search term along with "hair loss".

Peter H. Proctor, PhD,MD

 

[techprof]

http://www.drproctor.com/

 

[striker9]

So the best treatment is:

Revita shampoo

Nizoral as complement

And Tricomin or proctor products


I am correct?

 

[davestep]

i currently use 7%minoxidil solution every night. after reading these comments im going to add nizoral to my regime. will use this for a couple of months and then add nano or another product. will do this so i can see the benefits of each and determine which to continue. will keep you up to date with my progress. does anybody have a safe link for purchasing nizoral within the uk?? thanks

 

[rcom440]

So the best treatment is:

Revita shampoo

Nizoral as complement

And Tricomin or proctor products


I am correct?

In my opinion, there is no other shampoo that can beat Nizoral (keto).

 

[striker9]

You can't use revita all days, only 2/3 times a week.

So you use revita to alternate.

 

[striker9]

The perfect hair treatment!

The perfect hair shampoo is a ceto shampoo.

Alternated with revita.

And if you feel the hair dry you apply tricomin.



Is what i conclude from this topic

 

[pproctor]

A correction of a wrong impression. You can't equate our formulations with a single-agent treatment like trichomin or whatever.

With our products, you not only get analogous copper-peptide SODs ( on I which I hold the primary patents), you get a lot of other stuff besides. Having originated this technology over 20 years ago, by this time, we know what works optimally.

Peter H Proctor, PhD,MD