s5 cream??

[rcom440]

When it comes to spironolactone, the biggest challenge was to eliminate the odor. Try to compare the smell of liquid vs cream and you will know the answer.

I can't since I have neither.

Are you serious? You are not serious, are you?

Why not answer the question instead?

Liquid smell really bad. Cream still have the odor but it's not even close to the smell of the liquid.

So why not just mix up some pills in ethanol, water and PG?

It's not that easy to make spironolactone believe me I've tried and I know other people who tried as well. You can't just mix up some pills in ethanol water and PG Most likely you will stink the place up. Even if you know exact proportions most likely it will be a disaster.



spironolactone has been used by people, who experienced hair loss, for a while now but it's relatively new when you compare it to minoxidil, finasteride, dutasteride.

 

[first]

It's not that easy to make spironolactone believe me I've tried and I know other people who tried as well. You can't just mix up some pills in ethanol water and PG Most likely you will stink the place up. Even if you know exact proportions most likely it will be a disaster.

So you are saying that smell is the only problem? How bad is the smell once it has dried up?

Also, isn't ethanol the cause for the smell? So what happens when you mix it with for example DMSO and PG?

 

[rcom440]

It's not that easy to make spironolactone believe me I've tried and I know other people who tried as well. You can't just mix up some pills in ethanol water and PG Most likely you will stink the place up. Even if you know exact proportions most likely it will be a disaster.

So you are saying that smell is the only problem? How bad is the smell once it has dried up?

Also, isn't ethanol the cause for the smell? So what happens when you mix it with for example DMSO and PG?

Smell, yeah. You mix spironolactone with ethanol and it will stink as hell. You mix spironolactone and minoxidil and you a have a stink bomb as well. DMSO as well
Also, I don't know how effective home made spironolactone is and I dont want to be a ginny pig

When it's dry its not that bad, however, I believe it would stink on your scalp doe to the moisture of the scalp.

 

[first]

Smell, yeah. You mix spironolactone with ethanol and it will stink as hell. You mix spironolactone and minoxidil and you a have a stink bomb as well. DMSO as well.

How about PG?

 

[rcom440]

Smell, yeah. You mix spironolactone with ethanol and it will stink as hell. You mix spironolactone and minoxidil and you a have a stink bomb as well. DMSO as well.

How about PG?

I'm not sure but my best guess would be YES.
Are you planing to make spironolactone yourself? I read a post a while back of a guy who was able to achieve good solution and knew exact proportion, yes it saved him money but, as I remember, he said it was painful to make spironolactone and time consuming.

 

[first]

I'm not sure but my best guess would be YES.
Are you planing to make spironolactone yourself? I read a post a while back of a guy who was able to achieve good solution and knew exact proportion, yes it saved him money but, as I remember, he said it was painful to make spironolactone and time consuming.

I'm not planning to do it at this point but in the future it could be an option.

However, a cream isn't a good option as my hair isn't short and I would have to apply it to almost the entire scalp.

 

[amsch]

First, how you're doing with the RU/how long have you been on it, which percentage and is it your only treatment right now?

 

[rcom440]

I'm not sure but my best guess would be YES.
Are you planing to make spironolactone yourself? I read a post a while back of a guy who was able to achieve good solution and knew exact proportion, yes it saved him money but, as I remember, he said it was painful to make spironolactone and time consuming.

I'm not planning to do it at this point but in the future it could be an option.

However, a cream isn't a good option as my hair isn't short and I would have to apply it to almost the entire scalp.

It's hard to use spironolactone cream with longer hair but it's achievable. It takes more time and patience.

 

[striker9]

All I have to say is I've been using spironolactone( s5 cream) for 2 weeks now and my shedding is going down..

too good to be true ? Who knows ?

But in 1 week i'll be on RU58841 unk:

How are you going to get it???

 

[TA45]

Anyone have any results from the topical spironolactone? Someone(people) please come back and share????

 

[rcom440]

Anyone have any results from the topical spironolactone? Someone(people) please come back and share????

so far so good but I can't evaluate it fully. Still need some time. Anyone else please?

 

[TA45]

Thanks rcom44 for your reply.
I don't get it, time after time you read about different members of the forum getting on spironolactone topical yet you rarely here feedback. There is plenty of Finasteride feedback. Does this mean the topical spironolactone doesn't work? Rcom, I wish you success and look forward to your feedback, good or bad.
Tim

 

[rcom440]

Thanks rcom44 for your reply.
I don't get it, time after time you read about different members of the forum getting on spironolactone topical yet you rarely here feedback. There is plenty of Finasteride feedback. Does this mean the topical spironolactone doesn't work? Rcom, I wish you success and look forward to your feedback, good or bad.
Tim

I think spironolactone works but it's not as popular as finasteride and it's not as effective as finasteride but I believe that it does work. There are a lot of people who used spironolactone a couple of months and saw no difference so they just labeled it as snake oil without any proof just their experience over short period of time. Also, spironolactone is not going to regrow hair so for some people it may be hard to evaluate its effectiveness. It's a DHT inhibitor.

 

[rcom440]

More info about spironolactone:

" Topical Spironolactone: A study conducted by Berardesca E. et al concluded that 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. The inhibition of DHT receptors by spironolactone was found to be related to the decrease of tritiated DHT granules in the sebaceous glands of the treated site.... more info

Spironolactone is insoluble in water but easily soluble in alcohol. Since topical minoxidil is an alcohol based product, some forum members have simply added crushed Spironolactone tablets directly into topical minoxidil to make their own Spironolactone protocol. However, we cannot vouch if this is the proper way to make topical spironolactone. "

and

"Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris.

Berardesca E, Gabba P, Ucci G, Borroni G, Rabbiosi G.

Department of Dermatology, University of Pavia, Italy.

The interaction between spironolactone and dihydrotestosterone (DHT) receptors was evaluated with an autoradiographic technique. The inhibition of DHT receptors by spironolactone was found to be related to the decrease of tritiated DHT granules in the sebaceous glands of the treated site. 6 male patients affected by acne vulgaris entered the study. The acute study was performed by applying to 25 cm2 of the back a cream containing 5% spironolactone under occlusive dressing. The dosage of spironolactone applied was 4 mg/cm2 for 48 h. The long-term study was performed by applying the same amount to the entire back, without occlusion, twice daily for 1 month. Skin biopsies were taken at the end of the treatment, incubated with tritiated DHT and processed for autoradiography. Both the acute and the long-term study revealed a decrease of the autoradiographic granules in the treated site. This effect is related to the binding of spironolactone with dihydrotestosterone receptors in the sebaceous glands. Our study demonstrates that 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies."

 

[first]

How many % of the DHT did it inhibit however?

 

[rcom440]

How many % of the DHT did it inhibit however?

Don't know exactly, I would have to find those studies again. They are somewhere online but as far as I remember the results were impressive.

 

[first]

What's the recommended place to buy it (aka the cheapest)?

 

[Bryan]

How many % of the DHT did it inhibit however?

I'm not sure what you mean by that question. In any event, regardless of whatever it is you mean, the results of that study weren't expressed as any kind of a percentage.

 

[rcom440]

How many % of the DHT did it inhibit however?

I'm not sure what you mean by that question. In any event, regardless of whatever it is you mean, the results of that study weren't expressed as any kind of a percentage.

He probably meant how much of DHT was blocked.
I have to read more about it, I think there are more studies somewhere online about spironolactone.

 

[Bryan]

He probably meant how much of DHT was blocked.

Good luck to him on getting any kind of an answer to THAT question! Ive never seen such a figure given for ANY kind of antiandrogen (spironolactone, or anything else), regardless of whether they're used topically or systemically.