Samumed - SM04554

[Breyfogle]

Their second phase II trial was supposed to have data ready in March. Did we ever hear anything about that?

 

[mr_robot]

Because of the (unfounded at this point) claims of higher regrowth and or being the cure. SM04554 like CB is more or less finasteride without the sides when it comes to maintenance and regrowth, so not much hype.

No it's not, CB, finasteride, etc work by blocking AR related activity where as SM04554 as an WNT agonist, is a growth promoter.

 

[Breyfogle]

Found it. Can someone translate? I think the results are considerably more than 10% regrowth, especially for the .25% concentration group.
Not sure though. Science is hard.

https://www.samumed.com/medium/imag...matology-aad-orlando-fl-03042017_61/view.aspx

 

[Breyfogle]

It's seems that shedding stopped in the patients using the 2 different doses after 3 months compared to the placebo patients. Around 5 months, all hair types (vellus, terminal and "indeterminate) began to go up and up. The number varied depending on whether these guys were in telogen or anagen phase of hair growth. So it appears to reverse hairloss, yes. And it's only five months of data. That's not long enough to see full results.

Not to mention these are all advanced Norwoods 4-6, and many are over 40.

 

[resu]

No it's not, CB, finasteride, etc work by blocking AR related activity where as SM04554 as an WNT agonist, is a growth promoter.

I wasn't talking about the mechanisms but about the results, like for instance you can get regrowth and maintenance with minoxidil for a couple of years until you start going back to baseline.

 

[Trouse]

So just glancing at that PDF quickly, my interpretation of those charts is that there's not a big difference between the .15 and .25% groups. The .25% compound produces greater results at the 3 month mark, but then tapers off by day 135 whereas the weaker concentration performs better as more time goes on. Regardless, the drug was reportedly well tolerated by all participants, making the waiting game all the more excruciating.

 

[mr_robot]

I wasn't talking about the mechanisms but about the results, like for instance you can get regrowth and maintenance with minoxidil for a couple of years until you start going back to baseline.

No one knows that until it has been released and tested over many years. The mechanism is also very different compared to minoxidil.

 

[Afro_Vacancy]

I wasn't talking about the mechanisms but about the results, like for instance you can get regrowth and maintenance with minoxidil for a couple of years until you start going back to baseline.

A different mechanism matters, as it implies they might have synergy if used in combination.

 

[nameless]

A different mechanism matters, as it implies they might have synergy if used in combination.

I am really losing faith in everything. I have been waiting for 20 years and all I've gotten for my faith is false hopes.

 

[Afro_Vacancy]

I am really losing faith in everything. I have been waiting for 20 years and all I've gotten for my faith is false hopes.

Honestly man, you're too focused on the cure for ageing and living your 20s again.

Maybe your life will get a little better in five years, we can't say for sure. But you should focus on improving your life in the here and now, with resources that do exist, rather than what might exist in five years.

Even if Nirvana does emerge in 2021, you have to enjoy your time in the period 2017-20121.

 

[mr_robot]

Honestly man, you're too focused on the cure for ageing and living your 20s again.

Maybe your life will get a little better in five years, we can't say for sure. But you should focus on improving your life in the here and now, with resources that do exist, rather than what might exist in five years.

Even if Nirvana does emerge in 2021, you have to enjoy your time in the period 2017-20121.

I'm in the same position and I agree, in fact I've got one more potential thing I try and then I'm off this board. I've just hit my forties, last couple of years have been hell for me but nothing I guess compared to the poor kids on here who are NW3+ in their twenties.

 

[Afro_Vacancy]

I'm in the same position and I agree, in fact I've got one more potential thing I try and then I'm off this board. I've just hit my forties, last couple of years have been hell for me but nothing I guess compared to the poor kids on here who are NW3+ in their twenties.

How have they been hell?

 

[mr_robot]

How have they been hell?

Stress of losing your hair at that age is not exactly a walk in the park..

 

[br1]

Nah, wtf? I presented you a hypothesis. At 30 you can look the best, sure you will not look like a 16 year old kid you once were, but you can look good as a man in those years. That is when you have a full head of hair.

Also, it's retarded to think that your are already old at 24 or that others are old by that age.
And this topic has gone off the rails, as expected.

Chill.. I'm 40..

 

[Trichosan]

Honestly man, you're too focused on the cure for ageing and living your 20s again...

Wait 'till you're in mid 60's and divorced or widowed old girlfriends start popping up. The mind remembers how you rocked them in your twenties, then you look in the mirror...

It's inescapable, cruel. Yet, better not bald. But Afro_Vacancy is right-seize the day!

 

[pegasus2]

10% is nothing. I've seen studies where the vehicle increased hair growth that much.

 

[champpy]

I would pay handsomely for 10% permanant regrowth. Get me this sh*t now

 

[Stupidon]

10% is nothing. I've seen studies where the vehicle increased hair growth that much.

Yes vehicle with unicorn powder gave me amazing results too.

 

[pegasus2]

Yes vehicle with unicorn powder gave me amazing results too.

I don't recall which study that was, but the big minoxidil study showed a 5% improvement for vehicle.

"Compared to mean baseline counts of 103-106/cm2, at the end of 32 weeks treatment mean
increases in non-vellus hair counts were 39/cm2 in subjects who received 5% TMS (N=163),
30/cm2 in subjects who received 2% TMS (N=79), and 5/cm2 in subjects who received placebo"

10 percent is literally a joke. 10 percent isn't going to be noticeable to anyone but you, and it's not even significant enough to say that this drug works without further confirmation.

 

[Min0]

I don't recall which study that was, but the big minoxidil study showed a 5% improvement for vehicle.

"Compared to mean baseline counts of 103-106/cm2, at the end of 32 weeks treatment mean
increases in non-vellus hair counts were 39/cm2 in subjects who received 5% TMS (N=163),
30/cm2 in subjects who received 2% TMS (N=79), and 5/cm2 in subjects who received placebo"

10 percent is literally a joke. 10 percent isn't going to be noticeable to anyone but you, and it's not even significant enough to say that this drug works without further confirmation.

10% regrowth PLUS MAINTAINING what you have.
not everyone here is NW7 you know.