http://www.hairsite4.com/dc/dcboard.php?az=show_topic&forum=8&topic_id=21450&mode=full said:
>Date: Wed, 14 Apr 1999 17:54:40 -0500
>I am in my 30's, hair loss since 25 almost exclusively in the temple area.
>Hit a shed phase on Propecia at 3 months. The shed last for a month and a
>half. The result was that on the top of my head where it had been ok I lost
>way too much hair. My scalp is clearly visible through my hair on top now.
>All this in 4 months or so. I had the classic acne and oily face. Worst of
>all at 4 months I joined the "2%" who suffered "certain sexual side
>effects". It was bad getting worse.
>My decision was easy - I got off the drug. Since Merck never said shedding
>was possible I was suspicious. Since I had no decent diagnosis for the
>increase in loss I was scared. I decided not to gamble any further. I have
>not seen any regrowth since then (about a month off the drug). I can say
>that the sexual side effects are gone (whew!). No shedding (whew!!).
Most people do not experience a noticable shed of loss-phase
hair as follicles come out of dormancy under medical treatment. So it has
taken a while for it to become accepted. BTW, I claim bragging rights for
this discovery, since I saw it in a few patients in the mid-1980's ( one
advantage of treating a lot of people ). It has only been noted in the
Rogaine package insert in the last couple of years.
Most likely, unlike UpJohn ( who has a decade or two more
experience), Merck has not figured it out yet. This is possibly because
each of their investigators has only a hundred or so patients. A few
incidences of induced shedding would probably be dismissed as coicidental (
which is what I thought for a while ). This is particularly since it
occurs before 2-4 months, and thus only involves hair that was already in th
eloss-phase when treatment started. And everybody "knows" that nothing
affects loss phase hair<G>..
It gets even more complicated because there _may_ be a very few
additional cases in which reflex hyperandrogenicity has induced additional
hair loss with finasteride. This may happen indirectly in a way which
would probably not have shown up in the clinical trial.
E.g., tho I cannot currently point to a defined case, I can forsee a
stituation in which someone starts finasteride and experiences an induced
shed of loss phase hair. Remember, this is a good sign, because it
reflects follicles coming out of dormancy. They then stop finasteride
abruptly, exposing thier foillicles to the full fury<G> of reflex
hyperandrogenicity. This is why I advise tapering off this drug gradually,
to let things settle down a bit.
Peter H. Proctor, PhD, MD