Sm04554 Molecular Patent, What Would Be A Good Carrier?

[LifeIsSucks]

I havent seen this being posted anywhere but the molecular patent for sm04554 was released on november last year. Here is the link https://patentimages.storage.googleapis.com/4e/77/c1/d65cb7c1a87d2f/US20180333400A1.pdf

I also found this website selling sm04554 based off of this patent for "research purposes"
https://aobious.com/aobious/activators/13044-sm04554.html
What would be a good vehicle for this? Would it be similar to what we are using for the ru?

 

[Screeech]

Bump.

I'm going to get some off Alibaba.

Does anyone know how long it is stable for once dissolved and whether it will dissolve in stemox?

 

[NotInmywatch]

Bump.

I'm going to get some off Alibaba.

Does anyone know how long it is stable for once dissolved and whether it will dissolve in stemox?

are @screech you using iRestore?

since we do not know the exact polar profile and solubility data,
DMSO (a polar aprotic solvent) can be used as a topical vehicle ( https://www.ncbi.nlm.nih.gov/pubmed/19380203 )
maybe the vehicle is specified in any part of the patent??

 

[Screeech]

are @screech you using iRestore?

since we do not know the exact polar profile and solubility data,
DMSO (a polar aprotic solvent) can be used as a topical vehicle ( https://www.ncbi.nlm.nih.gov/pubmed/19380203 )
maybe the vehicle is specified in any part of the patent??

No, I am using Kiierr LLLT, because for $900 AUD ($650 USD) it was the cheapest I could get in Australia that had 272 diodes and the FDA papers suggest it is identical to all the more expensive options.

I have no idea if it is working at all, but I thought it wouldn't hurt at all as it is easy to use and they definitely do work, but it just varies how effective they are from person-to-person.

I have read DMSO ages skin, so I'm always a bit reluctant to use it.

I guess I will see if it dissolves in stemox first and go from there.

@Ollie, how did you end up dissolving yours? I saw you were buying some from your previous posts.

 

[Ollie]

No, I am using Kiierr LLLT, because for $900 AUD ($650 USD) it was the cheapest I could get in Australia that had 272 diodes and the FDA papers suggest it is identical to all the more expensive options.

I have no idea if it is working at all, but I thought it wouldn't hurt at all as it is easy to use and they definitely do work, but it just varies how effective they are from person-to-person.

I have read DMSO ages skin, so I'm always a bit reluctant to use it.

I guess I will see if it dissolves in stemox first and go from there.

@Ollie, how did you end up dissolving yours? I saw you were buying some from your previous posts.

Mine ended up being a waste of money dude. In the end i could get away with 10%DMSO along with ETH and PG but after about a week even that % of DMSO just causes your skin to blister like crazy. However i never experimented with DMI or other potentially less irritating solvents.

 

[LifeIsSucks]

Bump.

I'm going to get some off Alibaba.

Does anyone know how long it is stable for once dissolved and whether it will dissolve in stemox?

please update us if you managed to dissolve it in something, its very difficult for some reason to get sm04554 information on hairloss forums

 

[Screeech]

please update us if you managed to dissolve it in something, its very difficult for some reason to get sm04554 information on hairloss forums

Yeah, no one really seems to have tried it; everyone seemed to go for WAY when they were out at the same time (WAY has since ceased being trialled due to it's "safety profile".)

I have decided to leave using SM for another 6 months as I want to add seti and pge2 first for a while to get a read on how well everything is working.

I think with SM they were using .15% and .25% in the trials, I think using .075% would be a safe place to start with this somewhat unknown chemical, especially considering that the ,15% was more effective in the trials, and that I believe is a prevailing theme with WNT agonists where there is a tipping point where more actually starts having counter intuitive results.

In fact, they have restarted stage 2 or 3 of their trials recently with the purpose of revising the concentration, so I wouldn't be surprised if they are now trialling something like .10% or .075% anyway.

Also, only one place is selling it on Alibaba currently (not on Kane either), so not sure with what efficacy the bootleggers are able to synthesise it at currently, either.

 

[LifeIsSucks]

bump

 

[Sanchez1234]

I have WAY and SM04 at home. Tried to dissolve SM04 in almost 1everything without succes ( also stemox). Dsmo only thing that worked

 

[LifeIsSucks]

I have WAY and SM04 at home. Tried to dissolve SM04 in almost 1everything without succes ( also stemox). Dsmo only thing that worked

did you also get it form alibaba?

 

[Sanchez1234]

did you also get it form alibaba?

Yes but contacted wuhan via mail first. They than set a order in your account for protection.

 

[pegasus2]

I have WAY and SM04 at home. Tried to dissolve SM04 in almost 1everything without succes ( also stemox). Dsmo only thing that worked

Have you tried WAY? Any results? I'm thinking about trying it, but I would like to see that at least one person has tried it and is still alive lol

 

[LifeIsSucks]

bump

 

[pegasus2]

Yeah, no one really seems to have tried it; everyone seemed to go for WAY when they were out at the same time (WAY has since ceased being trialled due to it's "safety profile".)

I have decided to leave using SM for another 6 months as I want to add seti and pge2 first for a while to get a read on how well everything is working.

I think with SM they were using .15% and .25% in the trials, I think using .075% would be a safe place to start with this somewhat unknown chemical, especially considering that the ,15% was more effective in the trials, and that I believe is a prevailing theme with WNT agonists where there is a tipping point where more actually starts having counter intuitive results.

In fact, they have restarted stage 2 or 3 of their trials recently with the purpose of revising the concentration, so I wouldn't be surprised if they are now trialling something like .10% or .075% anyway.

Also, only one place is selling it on Alibaba currently (not on Kane either), so not sure with what efficacy the bootleggers are able to synthesise it at currently, either.

This is not true at all. WAY itself was never being trialled to begin with because the company doing the trials that you refer to does not own the patent for it. Here is their actual statement from that company: “Currently, we are in the process of identifying and developing other compounds than WAY-316606 that may unfold similar hair growth-promoting properties as the latter, but have an even more advantageous safety profile."

That is corporate speak for "we want to profit off of WAY-316606 so we are looking for similar compounds that we can patent".

Edit: The schools are really failing us when people don't know that adding the word "even" before "more advantageous" means that it already had an advantageous safety profile to begin with.

 

[LifeIsSucks]

@pegasus2 @Sanchez1234 @Screeech
So I emailed wuhan on alibaba and they said that dichloromethane also can dissolve sm04554

 

[LifeIsSucks]

I dont know how practical that is for topical usage, the side effects list stuff like "skin burn"

 

[pegasus2]

@pegasus2 @Sanchez1234 @Screeech
So I emailed wuhan on alibaba and they said that dichloromethane also can dissolve sm04554

View attachment 131814

Possibly carcinogenic. I'd rather use DMSO.

 

[Rambo219]

Did you guys get sm dissolved? Is dmso ok?
Anybody?