SM04554 Phase 2 results

[Hairloss23]

Yeah I'm not gonna lie the results aren't even that bad considering

a) they were on patients who are high norwoods
b) the patients have therefore been bald for a long time in most cases
c) it was only 3 months.

 

[buckthorn]

Yeah I'm not gonna lie the results aren't even that bad considering

a) they were on patients who are high norwoods
b) the patients have therefore been bald for a long time in most cases
c) it was only 3 months.

:bravo:

 

[c_super2]

What hopes do we have now?

That's what I want to know.

It seems all there is left is replicel and kerastem.

 

[IvanXproject]

The biggest downside with kerastem in my opinion is that it will leave you with scars on your stomach..

 

[hellouser]

Yeah I'm not gonna lie the results aren't even that bad considering

a) they were on patients who are high norwoods
b) the patients have therefore been bald for a long time in most cases
c) it was only 3 months.

Yup. The three months timespan is key here. I suppose everyone is expecting immediate regrowth... hair doesn't grow like that, not even when healthy after a shed as it typically last several months at least.

 

[Coiffio]

Didn't know about the 3 month part. Hopefully 6+ months does it more justice. Also, with all of this 50% more hair on minoxidil talk, I think I should finally give it a try! I'd be the world's thickest NW2 if I'm lucky enough to be one of those mythical elite responders.

There seem to be two camps with expectations for hair loss drugs.

Camp a: who have lost too much hair already and need something to bring it back

Camp b: who still have enough hair (or can use an hair transplant to get the illusion of it) and just need something to keep it.

Both totally different requirements.

So these results: the control group lost hair, but the drug users gained 10% (or 15 if you go from control group).

This is awesome for the b camp people. Even if it could only keep at baseline, that's still perfect.

I feel sorry for my brothers here in camp a, but for us lucky ones in camp b, these kind of results are still exciting for us...

Is there anything to suggest this gives long term maintenance? No one turns NW7 in just 3 months.

 

[Pray The Bald Away]

http://image-store.slidesharecdn.com/750e6989-7da5-4f4a-bcff-0244aa842f10-original.jpeg

 

[MrJolly16]

What have you said about April? Are they going to continue with the trial or are they going to begin a new one?

I have not lost hope, not yet!

Regards from Spain

 

[hellouser]

http://image-store.slidesharecdn.com/750e6989-7da5-4f4a-bcff-0244aa842f10-original.jpeg

Any photos of the slides from the presentation?

 

[Toddskii]

I heard that Forbes article was released before the presentation?

 

[IvanXproject]

http://image-store.slidesharecdn.com/750e6989-7da5-4f4a-bcff-0244aa842f10-original.jpeg

You actually were there?

 

[hellouser]

I heard that Forbes article was released before the presentation?

Same here, and it reads like that too.

 

[Pray The Bald Away]

Any photos of the slides from the presentation?

It's from an employee's twitter.

- - - Updated - - -

Same here, and it reads like that too.

It was probably pre written with the info and couldn't be released because the embargo. I wouldn't get your hopes up.

 

[lynney45]

Disappointed - will be following through with Shapiro this summer, i awaited these results before fully comittimg. Staying on cb and seti topically for maintenance then will probably tackle histogen or replicel once they are on the market. No more waiting lads, we make the best of what we have available today. Whats the point of going through tgis misery on a daily basis looking into the future with a crystal ball. End the suffering now with a hair transplant then work with other treatments in the future. Dont let your 20/30's go to waste, these are the days where you are in the prime of your life. Ok we have to compromise our donor density, but really who gives a **** nobody looks at the back of your head anyway, when people talk to you they look at your face.

 

[Afro_Vacancy]

10% regrowth after three months on high norwoods is good.

Wth that said, why did they handicap themselves with a 3-month trial?

 

[nameless]

10% regrowth after three months on high norwoods is good.

Wth that said, why did they handicap themselves with a 3-month trial?

I don't know. And that has never made sense to me. We KNOW from science that the moment they cease treatment the hair should start falling out again. We know this because they did an experiment where they injected androgens into a castrated man who had a full head of hair that would have already been lost but for the fact that he had been castrated. They know he would have lost his hair if he hadn't been castrated because his identical twin was bald by the time of the experiment. Anyway, after injecting him with androgens his hair started falling out rapidly. He lost it within a few months instead of over years. This experiment shows that the moment a man is taken off a medical treatment for hair loss the androgens will start doing their dirty-work and he will rapidly lose any hair that should have been lost by that point in time.

 

[Hairloss23]

I don't know. And that has never made sense to me. We KNOW from science that the moment they cease treatment the hair should start falling out again. We know this because they did an experiment where they injected androgens into a castrated man who had a full head of hair that would have already been lost but for the fact that he had been castrated. They know he would have lost his hair if he hadn't been castrated because his identical twin was bald by the time of the experiment. Anyway, after injecting him with androgens his hair started falling out rapidly. He lost it within a few months instead of over years. This experiment shows that the moment a man is taken off a medical treatment for hair loss the androgens will start doing their dirty-work and he will rapidly lose any hair that should have been lost by that point in time.

I don't think that Sammumed are concerned with their patients hair loss getting worse. Ugly desperate bald guys are everywhere, they can get more subjects with a snap of their fingers.

 

[nameless]

I don't think that Sammumed are concerned with their patients hair loss getting worse. Ugly desperate bald guys are everywhere, they can get more subjects with a snap of their fingers.

Of course Samumed doesn't care about the test subject becoming ugly but the point is that when Samumed made their test subjects stop
using SM04554 after just 3 months the patient's (hair-growth) progress halted at that point and the patients actually started losing any gains they had already made.
The patients may have even had more hair at 3 months (the last day they used SM04554) than they did at 6 months, which was 3 months after they stopped using SM04554.
And they did their final hair counts at or after the 6-month mark. Applying the drug for 3-months has always looked like an obvious mistake to me.

 

[paleocapa89]

What puzzles me though is how can the test subjects have 100 hair/cm2 on average if they are high norwood patients. Sh*t, I don't even have that density even though I am not high norwood.

 

[Afro_Vacancy]

What puzzles me though is how can the test subjects have 100 hair/cm2 on average if they are high norwood patients. Sh*t, I don't even have that density even though I am not high norwood.

They probably went to a section of the head with high hair density ...