Spironolactone...where does it truly fit in

[RaginDemon]

No, the study makes perfect sense.

DHT is what causes a lot of changes related to puberty and ageing. As we get older, most men start facing thinning scalp hair, and increasing body hair. DHT is the trigger for both.

Thus, using spironolactone would thicken hair that is programmed to thin when DHT binds to it, and would also thin out hair that is programmed to thicken when DHT binds to it.

finasteride works the same way, thats why many experienced reduced body hair after using finasteride.

 

[ukdesi]

Study

This is found on revivogen's website:


Product Research

Azelaic Acid, Vitamin B6 and Zinc Sulfate

Inhibition of 5alpha-reductase activity in human skin by zinc and Azelaic acid.

AUTHOR
Stamatiadis, D; Bulteau-Portois, MC; Mowszowicz, I.

JOURNAL
British Journal of Dermatology, 1988 Nov, 119(5):627-32.

ABSTRACT
The effects of zinc sulfate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5-alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc, but not of azelaic acid, suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulfate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.


RETURN TO RESEARCH

 

[CCS]

No, the study makes perfect sense.

DHT is what causes a lot of changes related to puberty and ageing. As we get older, most men start facing thinning scalp hair, and increasing body hair. DHT is the trigger for both.

Thus, using spironolactone would thicken hair that is programmed to thin when DHT binds to it, and would also thin out hair that is programmed to thicken when DHT binds to it.

so put it in your body wash, use a wash cloth, and let it sit 5 minutes. But I prefer my GTE, which also is an anti-oxidant and 5ar blocker.