Those upregulated gene studies are garbage because the hair follicle needs to be analyzed in a scaffold type environment. Failure to do this and putting cells in a flat petri dish gives erroneous results.
I'm out of time but IIRC something like 200 gene expressions are changed by not following an "in-vivo"like culturing approach. All genes are effected by the tiniest of things too even if say homocysteine was too high in male pattern baldness this would not be reflected in this gene culture.
Dr. Christiano's research:
Tissue engineering of human hair follicles using a biomimetic developmental approach
I'm out of time but IIRC something like 200 gene expressions are changed by not following an "in-vivo"like culturing approach. All genes are effected by the tiniest of things too even if say homocysteine was too high in male pattern baldness this would not be reflected in this gene culture.
Dr. Christiano's research:
Tissue engineering of human hair follicles using a biomimetic developmental approach