Michel L, Reygagne P, Benech P, et al. Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways. Br J Dermatol 2017;177:1322-36.
BACKGROUND: Male androgenetic alopecia (Androgenetic Alopecia) is the most common form of hair loss in men. It is characterized by a distinct pattern of progressive hair loss starting from the frontal area and the vertex of the scalp. Although several genetic risk loci have been identified, relevant genes for Androgenetic Alopecia remain to be defined.
OBJECTIVES: To identify biomarkers associated with Androgenetic Alopecia.
METHODS: Molecular biomarkers associated with premature Androgenetic Alopecia were identified through gene expression analysis using cDNA generated from scalp vertex biopsies of hairless or bald men with premature Androgenetic Alopecia, and healthy volunteers.
RESULTS: This monocentric study reveals that genes encoding mast cell granule enzymes, inflammatory mediators and immunoglobulin-associated immune mediators were significantly overexpressed in Androgenetic Alopecia. In contrast, underexpressed genes appear to be associated with the Wnt/beta-catenin and bone morphogenic protein/transforming growth factor-beta signalling pathways.
Although involvement of these pathways in hair follicle regeneration is well described, functional interpretation of the transcriptomic data highlights different events that account for their inhibition.
In particular, one of these events depends on the dysregulated expression of proopiomelanocortin, as confirmed by polymerase chain reaction and immunohistochemistry. In addition, lower expression of CYP27B1 in patients with Androgenetic Alopecia supports the notion that changes in vitamin D metabolism contributes to hair loss.
CONCLUSIONS: This study provides compelling evidence for distinct molecular events contributing to alopecia that may pave the way for new therapeutic approaches.
here the full article : http://onlinelibrary.wiley.com/doi/10.1111/bjd.15577/full
BACKGROUND: Male androgenetic alopecia (Androgenetic Alopecia) is the most common form of hair loss in men. It is characterized by a distinct pattern of progressive hair loss starting from the frontal area and the vertex of the scalp. Although several genetic risk loci have been identified, relevant genes for Androgenetic Alopecia remain to be defined.
OBJECTIVES: To identify biomarkers associated with Androgenetic Alopecia.
METHODS: Molecular biomarkers associated with premature Androgenetic Alopecia were identified through gene expression analysis using cDNA generated from scalp vertex biopsies of hairless or bald men with premature Androgenetic Alopecia, and healthy volunteers.
RESULTS: This monocentric study reveals that genes encoding mast cell granule enzymes, inflammatory mediators and immunoglobulin-associated immune mediators were significantly overexpressed in Androgenetic Alopecia. In contrast, underexpressed genes appear to be associated with the Wnt/beta-catenin and bone morphogenic protein/transforming growth factor-beta signalling pathways.
Although involvement of these pathways in hair follicle regeneration is well described, functional interpretation of the transcriptomic data highlights different events that account for their inhibition.
In particular, one of these events depends on the dysregulated expression of proopiomelanocortin, as confirmed by polymerase chain reaction and immunohistochemistry. In addition, lower expression of CYP27B1 in patients with Androgenetic Alopecia supports the notion that changes in vitamin D metabolism contributes to hair loss.
CONCLUSIONS: This study provides compelling evidence for distinct molecular events contributing to alopecia that may pave the way for new therapeutic approaches.
here the full article : http://onlinelibrary.wiley.com/doi/10.1111/bjd.15577/full
